DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment oxt and Wscd2

DIOPT Version :9

Sequence 1:	NP_647705.1	Gene:	oxt / 38288	FlyBaseID:	FBgn0015360	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_796266.2	Gene:	Wscd2 / 320916	MGIID:	2445030	Length:	571	Species:	Mus musculus

Alignment Length:	706	Identity:	143/706 - (20%)
Similarity:	232/706 - (32%)	Gaps:	237/706 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WLKRYRAF---------FLILLLIVAIQLFLAYKSLDIVGGGSGSGFDAAEAPASPPPPHAQARV 64
            |.|..|.|         |..||.|     :|...||..:    .|||  ...||.|     |::.
Mouse     5 WFKFQRCFRYFRRKPVRFFTLLAI-----YLTAGSLVFL----HSGF--VGQPAVP-----QSQA 53

  Fly    65 QPPARTKLTAQQLGFQPECDILAR------EAISALQR----AKTKDCREHIAQIACAIQAGRFY 119
            .|.|.:.:...:|.|..:.. |.|      ||.|..:|    .|.||..|. |::.   ..|..:
Mouse    54 SPAAGSPVEGAELPFLGDLH-LGRGFRDTVEASSIARRYGPTFKGKDTSER-AKLG---DYGGAW 113

  Fly   120 APQLRSSCPAGNHTANVS-----LGCFKDEKDRRLLAGYYSSSKTSNSPAKCVELCLQSGYPYAG 179
            :..|:.............     :||:.|:...|.|.|.........:..:|.:.|.:.||.|||
Mouse   114 SRALKGRVVREKEKEKEEEKAKYIGCYLDDTQSRALRGVSFFDYKKMTVFRCQDNCAERGYLYAG 178

  Fly   180 VQYGRECFCGYDPPPKASKLPDSSCNTKCLGNAKEICGGFYAMNIYETGIAKFTAQLAATTPSEE 244
            :::|.||:||:  ..:|:.:.:|.|:.:|.|....:|||...:::|...:|:           |.
Mouse   179 LEFGAECYCGH--KIQAANVSESDCDMECKGERGSVCGGINRLSVYRLQLAQ-----------ES 230

  Fly   245 TKRVRIAFLLTLNGRALRQVHRLLKALYAPEHVYYIHVDERQDYLYRKLLELESKFPNIRLARKR 309
            .:|...|   ...| ..|:.:.|..||.....:..:.||:..|      |..|.:||...||
Mouse   231 ARRYGSA---VFRG-CFRRPNNLSLALPVSAAMPNMSVDKCVD------LCTEKEFPLAALA--- 282

  Fly   310 FSTIWGGASLLTMLLQCMEDLLQSNWHWDFVINLSESDFPVKTLDKLVDFLSANPGRNFVKGHGR 374
                 |.|        |         |..|    ..:.||:                     |.|
Mouse   283 -----GTA--------C---------HCGF----PTTRFPL---------------------HDR 300

  Fly   375 ETQKFIQKQGLDKTFVECDTHMW-----------RIGDRK-LPAGIQ--------VDGGSDWV-- 417
            |.::...::...:.|..|.|..:           |..||: |||..:        ...|:.|.
Mouse   301 EDEQLCAQKCSAEEFESCGTPSYFIVYQTQVQDNRCMDRRFLPAKSKKLIALASFPGAGNTWARH 365

  Fly   418 ------------------ALSRPFVGYVTHPR-------EDDELLQALLKLFRHTLLPAESFFHT 457
                              ..::.|.|...|.|       :..|..|..::.|...:|
Mouse   366 LIELATGFYTGSYYFDGSLYNKGFKGERDHWRSGRTICIKTHESGQKEIEAFDAAIL-------- 422

  Fly   458 VLRNTKHCTSYVDNNLHVTNWKRKQGCKCQYKHVVDWCGCSPNDFKPEDWPRLQATEQKSLFFAR 522
            ::||.....        :..:.||.|....:.....|        |.::||.          |.|
Mouse   423 LIRNPYKAL--------MAEFNRKYGGHIGFAAHAHW--------KGKEWPE----------FVR 461

  Fly   523 KFEPVINQAVLLQLEEWLYGPYTSEYANLHGYWQSLYHHEDVHGSGDDLARSIGD--SVMRLSAR 585
            .:.|            | :..:|.::... |....:.|.||:.   .||...:|.  |::.::.|
Mouse   462 NYAP------------W-WATHTLDWLKF-GKTVLVVHFEDLK---QDLFTQLGRMVSLLGVAVR 509

  Fly   586 QAKLYPLELIELTHY-------LHRDQYKGFLVR------------YRARGSTGKP 622
            :.:|..:|..:..::       |..|.|...:.|            .|:|..||.|
Mouse   510 EDRLLCVESQKDGNFKRSGLRKLEYDPYTAEMRRTIAAYIRMVDTALRSRNLTGVP 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
oxt	NP_647705.1	WSC	138..218	CDD:280068	24/79 (30%)
		Branch	250..503	CDD:280621	50/299 (17%)
		Xylo_C	537..710	CDD:289306	22/107 (21%)
Wscd2	NP_796266.2	WSC	134..225	CDD:214616	27/92 (29%)
		WSC	236..330	CDD:214616	28/153 (18%)
		Sulfotransfer_3	<421..>513	CDD:389806	24/142 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847055
Domainoid	1	1.000	62	1.000	Domainoid score	I10298
eggNOG	1	0.900	-	-		E1_KOG4157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.830