DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment oxt and Xylt1

DIOPT Version :9

Sequence 1:	NP_647705.1	Gene:	oxt / 38288	FlyBaseID:	FBgn0015360	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_783576.2	Gene:	Xylt1 / 233781	MGIID:	2451073	Length:	953	Species:	Mus musculus

Alignment Length:	855	Identity:	306/855 - (35%)
Similarity:	437/855 - (51%)	Gaps:	146/855 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GGSGSGFDAAEAPASPPPPHAQARVQPPARTKLTAQQLGFQPECDILAREAISALQRAKTKDCRE 104
            |.|..|.|.:.        |:.||......:..|.....  |:|||..:||||||.|||:|.||:
Mouse   218 GNSSQGKDLSR--------HSHARKSGGGGSPETKSDQA--PKCDISGKEAISALTRAKSKHCRQ 272

  Fly   105 HIAQIACAIQAGRFYAPQLRSSCPAGNHTANVSLGCFKDEKDRRLLAGYYSSSKTSNSPAKCVEL 169
            .||:..|..:.|                                ||           .|.|....
Mouse   273 EIAETYCRHKLG--------------------------------LL-----------MPEKVARF 294

  Fly   170 CLQSGYPYAGVQYGRECFCGYDPPPKASKLPDSSCNTKCLGNAKEICGGFYAMNIYETGIAKFTA 234
            |...|.....||:..:. ..|.|
Mouse   295 CPLEGKANKNVQWDEDA-VEYMP------------------------------------------ 316

  Fly   235 QLAATTPSEETKRVRIAFLLTLNGRALRQVHRLLKALYAPEHVYYIHVDERQDYLYRKLLELESK 299
                      ...|||||:|.::|||.||:.|:.||:|..:|.||||||:|.:||:|::|:...:
Mouse   317 ----------ANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQFSRQ 371

  Fly   300 FPNIRLARKRFSTIWGGASLLTMLLQCMEDLLQ-SNWHWDFVINLSESDFPVKTLDKLVDFLSAN 363
            :.|:|:...|.:|||||||||:..||.|.|||: ::|.|||.||||.:|:|::|.|:||.|||..
Mouse   372 YDNVRVTSWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRY 436

  Fly   364 PGRNFVKGHGRETQKFIQKQGLDKTFVECDTHMWRIGDRKLPAGIQVDGGSDWVALSRPFVGYVT 428
            ...||:|.|||:..:||:|||||:.|:||||||||:|||::|.||.|||||||..|:|.||.||.
Mouse   437 RDMNFLKSHGRDNARFIRKQGLDRLFLECDTHMWRLGDRRIPEGIAVDGGSDWFLLNRKFVEYVA 501

  Fly   429 HPREDDELLQALLKLFRHTLLPAESFFHTVLRNTKHCTSYVDNNLHVTNWKRKQGCKCQYKHVVD 493
            .  ..|:|:..:.:.:.:|||||||||||||.|:.||.:.|||||.:|||.||.||||||||:||
Mouse   502 F--STDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVD 564

  Fly   494 WCGCSPNDFKPEDWPRLQATEQKSLFFARKFEPVINQAVLLQLEEWLYGPYTSEYANLHGYWQSL 558
            |||||||||||:|:.|.|.|.:.: |||||||.::||.::.||:.:|||.|.:....|..||:::
Mouse   565 WCGCSPNDFKPQDFHRFQQTARPT-FFARKFEAIVNQEIIGQLDSYLYGNYPAGTPGLRSYWENV 628

  Fly   559 YHHEDVHGSGDDLARSIGDSVMRLSARQA------------KLYPLELIELTH-YLHRDQYKGFL 610
            |...|...:..|:|.::..|.:||..|:|            :.||:......| |...|:::|||
Mouse   629 YDEPDGIHTLSDVALTLYHSFIRLGLRRAESSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFL 693

  Fly   611 VRYRARG-STGKPLHLETRVRPTQQGKLARNARFSKRLRNFEVSTDFDQKEQIARNFGKLLGPQS 674
            :::.... :..|...|||.:.|.:..|:|.......||:..||.||:|.||::.||||.||||..
Mouse   694 IKHHVTNLAVSKLETLETWMMPKKVFKVASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMD 758

  Fly   675 DLLLSYTLQANADSGAASHSYNLTLLWIDPLGRLQDFNELHVEDSTSDVINHSKTLLKHPITPGI 739
            :       ...........:..:|::|:||:..:....::.:| ||:: ..|.|..|..|:.||:
Mouse   759 E-------PVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIE-STAE-FTHYKPPLNLPLRPGV 814

  Fly   740 WTAKLIGRNSIYAQLKFLIAPLAYYKGYPLAKSSDAEALNAGLTVALPEDFEMPVEWQQ-----H 799
            ||.|::......|:.|||:|||.:....|: |..:|..|:.|    .|....|...:|.     .
Mouse   815 WTVKILHHWVPVAETKFLVAPLTFSNKQPI-KPEEALKLHNG----PPRSAYMEQSFQSLNPVLS 874

  Fly   800 LQTDDEQFTMREESLAKGKMLGQELHSWIDGLVGQFFQLRESCVVEADSEVSLPLCSDAPWSSLA 864
            |..:..|.   |::.......|..|.:|:|.|||..:...:.|.....:...:..||...|||.:
Mouse   875 LHINPAQV---EQARKNAAFTGTALEAWLDSLVGGTWTAMDICTTGPTACPVMQTCSQTAWSSFS 936

  Fly   865 PDPKSDVDAL 874
            |||||::.|:
Mouse   937 PDPKSELGAV 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
oxt	NP_647705.1	WSC	138..218	CDD:280068	10/79 (13%)
		Branch	250..503	CDD:280621	147/253 (58%)
		Xylo_C	537..710	CDD:289306	52/186 (28%)
Xylt1	NP_783576.2	Branch	322..574	CDD:280621	147/253 (58%)
Xylt1	NP_783576.2	Xylo_C	607..787	CDD:289306	52/186 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847060
Domainoid	1	1.000	334	1.000	Domainoid score	I1132
eggNOG	1	0.900	-	-		E1_KOG0799
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32534
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1168
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49999
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003123
OrthoInspector	1	1.000	-	-		otm43711
orthoMCL	1	0.900	-	-		OOG6_102671
Panther	1	1.100	-	-	O	PTHR46025
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2902
SonicParanoid	1	1.000	-	-		X616
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790