DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32301 and Phlpp1

DIOPT Version :9

Sequence 1:NP_728724.2 Gene:CG32301 / 38285 FlyBaseID:FBgn0052301 Length:1111 Species:Drosophila melanogaster
Sequence 2:NP_598582.3 Gene:Phlpp1 / 98432 MGIID:2138327 Length:1687 Species:Mus musculus


Alignment Length:294 Identity:56/294 - (19%)
Similarity:107/294 - (36%) Gaps:97/294 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   294 LEADMVDFTGLTTTMEVSD------------LVAILH---ELFVSFD--------LAANHNRATR 335
            |.||.|||....|.:::.|            .:.:||   ...|:.:        |.|:.|...:
Mouse   778 LMADEVDFVQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLNVCGYFLKALYASSNELAQ 842

  Fly   336 ---------IKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISR----EVSKRRNKKIDLRIG 387
                     :.::..|..|:..:|.:      .|.::.|::::|..    |:..|......||  
Mouse   843 LDVYPVPNYLSYMDVSRNCLESVPEW------VCESRKLEVLDIGHNQICELPARLFCNSSLR-- 899

  Fly   388 VHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKL 452
                ::|||...|.:           :..|||.:           ::.:||..:     ....:|
Mouse   900 ----KLLAGHNRLAR-----------LPERLERT-----------SVEVLDVQH-----NQITEL 933

  Fly   453 DP-LLQRSNLSTYLIRS-----RLPN---FEDTDDLEDDNFSLNDYRFSFSFSQDYEDIQVKAQR 508
            .| ||.:::...:|..|     .||.   .|:|..:..:.:..|:     ..:.....:.....|
Mouse   934 PPNLLMKADSLRFLNASANKLETLPPATLSEETSSILQELYLTNN-----CLTDKCVPLLTGHPR 993

  Fly   509 DMILEVEHMPVNRVQTCKIRRPMHRIAK-EDINE 541
               |::.||..||:|:.    |..::|| |::.|
Mouse   994 ---LKILHMAYNRLQSF----PASKMAKLEELEE 1020

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32301NP_728724.2 Nucleotidyl_cyc_III 283..439 CDD:299850 32/180 (18%)
CYCc 812..1051 CDD:214485
Nucleotidyl_cyc_III 841..1076 CDD:299850
Phlpp1NP_598582.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..406
PH_PHLPP-like 491..587 CDD:270131
PH 511..592 CDD:278594
LRR_RI 581..885 CDD:238064 20/112 (18%)
LRR_8 594..659 CDD:290566
LRR 1 594..615
leucine-rich repeat 597..617 CDD:275380
LRR 2 617..638
leucine-rich repeat 618..648 CDD:275380
LRR_8 647..726 CDD:290566
LRR 3 648..669
LRR 4 671..692
leucine-rich repeat 672..694 CDD:275380
LRR 5 694..715
leucine-rich repeat 695..717 CDD:275380
LRR 6 717..739
leucine-rich repeat 718..740 CDD:275380
LRR 7 740..760
leucine-rich repeat 741..764 CDD:275380
LRR 8 764..785 4/6 (67%)
LRR_RI 768..1030 CDD:238064 56/294 (19%)
leucine-rich repeat 768..788 CDD:275380 6/9 (67%)
LRR 9 788..809 2/20 (10%)
leucine-rich repeat 789..809 CDD:275380 2/19 (11%)
leucine-rich repeat 810..851 CDD:275380 6/40 (15%)
LRR 10 829..850 3/20 (15%)
LRR 11 851..872 4/26 (15%)
leucine-rich repeat 852..874 CDD:275380 4/27 (15%)
LRR 12 874..895 4/20 (20%)
leucine-rich repeat 875..897 CDD:275380 4/21 (19%)
LRR_8 896..954 CDD:290566 17/90 (19%)
LRR 13 897..918 9/37 (24%)
leucine-rich repeat 898..919 CDD:275380 9/48 (19%)
LRR 14 919..940 6/25 (24%)
leucine-rich repeat 920..943 CDD:275380 6/27 (22%)
LRR 15 943..964 4/20 (20%)
leucine-rich repeat 944..967 CDD:275380 5/22 (23%)
LRR 16 969..989 1/24 (4%)
LRR_8 970..1028 CDD:290566 13/63 (21%)
leucine-rich repeat 970..993 CDD:275380 1/27 (4%)
LRR 17 993..1014 8/27 (30%)
leucine-rich repeat 994..1017 CDD:275380 9/26 (35%)
LRR 18 1017..1038 1/4 (25%)
LRR 19 1040..1061
LRR 20 1062..1083
leucine-rich repeat 1063..1085 CDD:275380
LRR 21 1085..1106
PP2Cc 1124..1376 CDD:214625
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1414..1465
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1604..1687
PDZ-binding 1685..1687
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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