Protein Alignment CG32301 and Adcy7

DIOPT Version :10

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_445848.1
• Gene: Adcy7 / 84420
• RGDID: 619966
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 1179
• Identity: 301/1179 - (25%)
• Similarity: 493/1179 - (41%)
• Gaps: 289/1179 - (24%)

  Fly    41 RHCHLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDFLTVLPYFAVMLLTPSILMPSREPNVEQ 105
            ||..::..|.. .|.:.:.:.:|::|..|  ..:.:..|.:|.:..:|:|...::..|.|.....
  Rat    61 RHQAVLGTAFF-MLTLFVALYVLVYVECL--AQRWLRVLALLTWACLMILGSVLMWDSLENEAYA 122

  Fly   106 YESIAILVSCLMALLLTAMDLILPICYFRPFSLVPSYDHVVIVLIYLMFPIAFVKNGRAYFLGLA 170
            :|.:                         ||.|      .::.::|::.|::   ...|..:|:|
  Rat   123 WEQV-------------------------PFFL------FIVFVVYVLLPLS---TRAAIAVGVA 153

  Fly   171 VS---LFYFGYM--ALIDKISTLDKVWELTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVV 230
            .:   |..||.:  |....:|:.....:|.|....|...|    |...|.::.::..  ||...:
  Rat   154 STISHLLVFGAVTRAFKTSMSSTQLGLQLLANAVILLGGN----FTGAFHKHQLQDA--SRDLFI 212

  Fly   231 YQNLVFQMAMK------EEKALLDSIIPVTLARSLQDAIASHIEE-DPSNLMPFTKTRHLFMEPH 288
            |.....|:..|      :::.||.|::|..::..::.||...::| ...:..|......|:::.|
  Rat   213 YTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHYTPDNNFHSLYVKRH 277

  Fly   289 PEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYF 353
            ..||||.||:|.||.|.:.....:||.:|:|||..||..|..|...|||.|||.|.||:|:|...
  Rat   278 QNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSL 342

  Fly   354 PTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRL 418
            ||||..||...||:.|..::|.:.....|.:|:|:|||.:|.|:|||.|||:|:||.||.:.||:
  Rat   343 PTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRM 407

  Fly   419 ESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLI---RSR---LPNFEDTD 477
            |::|:||.|||:..||..||..|..|:|....: ||.|:..|:.|||:   ||:   ||:...:.
  Rat   408 EAAGVPGRVHITEATLNHLDKAYEVEDGHGEQR-DPYLKEMNIRTYLVIDPRSQQPPLPSHHLSK 471

  Fly   478 DLEDDNFSL------NDYRFSFSFSQDYEDIQVKAQRDMILEVEHMPV---NRVQTCKIRR---- 529
            ...|....:      ..|..|:..::.:..:.   .|:.:...| :|:   .|.:...:||
  Rat   472 PKGDATLKMRASVRVTRYLESWGAARPFAHLN---HRESVSSSE-IPIPNGRRQKAIPLRRHRAP 532

  Fly   530 -----PMHRIAKEDINEEYRFHLESYYL----------FTTFRSWRMEWSFNKMRDLL----MKY 575
                 |..|: ::|.::|....:|....          |.||....:|..|.:...|:    .:|
  Rat   533 DRSASPKGRL-EDDCDDEMLSAIEGLSSTRPCCSKSDDFHTFGPIFLEKGFEREYRLVPIPRARY 596

  Fly   576 SLGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFL 640
            ...........|:.:.|||........:.|.| :..||.|:|                   :|..
  Rat   597 DFACASLVFVCILLVHLLVMPRMATLGLSFGL-VACLLGLVL-------------------SFCF 641

  Fly   641 SRWFIKA----------SDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCDIARLELEIINSELH 695
            :..|.:.          |:.:|....:|:.|.::.:..|               |.:.|||..|.
  Rat   642 ATEFSRCLPARSTLQAISESVETQPLLRLSLVVVTVGSL---------------LTVAIINMPLT 691

  Fly   696 --------------------------NLRPQMLC-----FMPWGVTYAVVIVLSLMLVIIGIP-- 727
                                      .|.|...|     |:...|...:.:.|..||:.:.:.
  Rat   692 FNPGPEQPGDNETSPLAARNRVGTPCELLPYYTCSCVLGFIACSVFLRMSLELKAMLLTVALVAY 756

  Fly   728 -LIIKLGVGLAILG----------------------SHVITVHAYY-----GFAFERSQTTNIGV 764
             |:..|.....:.|                      ||.:.:.|..     ....||...|.|
  Rat   757 LLLFNLSPCWQVSGNSTETNSTHRTRRLLSAEQSMNSHTLALGAQMTAPSPSSCLERDLKTMI-- 819

  Fly   765 TSSLAHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVA 829
                  ::|:|.|:..:::....::|..:........|:|:||..:......::::.|:||.|||
  Rat   820 ------NFYLVLFYATLILLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVA 878

  Fly   830 EVFKVRRRSDQLYYENFSQVAVMFATIENY-------EADKSG---LRALHEMICYFDELLVNYQ 884
            ..|...:.::..|::::..|.||||::.::       :.:|.|   ||.|:|:|..|||||:. .
  Rat   879 AHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLK-P 942

  Fly   885 SWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDL 949
            .:..:||||.:|.||:||.||          |||  :..|:..|::                |.:
  Rat   943 KFSGVEKIKTIGSTYMAAAGL----------SVP--SGHENQDLER----------------KHV 979

  Fly   950 HPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTG---------SLKIGIAHGP 1005
            |            |.|:.||::.|:                |||.|         .|::||.|||
  Rat   980 H------------IGVLVEFSMALM----------------SKLDGINRHSFNSFRLRVGINHGP 1016

  Fly  1006 VMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQ 1070
            |:|||:|..||.|||||:|||:||||.|||....|.|||.|..:|:.....|..||:..|||.|:
  Rat  1017 VIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGE 1081

  Fly  1071 VPTYLVDLD 1079
            :.||.|..|
  Rat  1082 LRTYFVCTD 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	119/405 (29%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	74/155 (48%)
		AcyC	681..1076	CDD:441717	126/474 (27%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	88/253 (35%)
Adcy7	NP_445848.1	AcyC	48..461	CDD:441717	133/443 (30%)
		Guanylate_cyc	272..422	CDD:425528	71/149 (48%)
		Adcy_cons_dom	487..594	CDD:461877	19/111 (17%)
		Guanylate_cyc	891..1087	CDD:425528	88/252 (35%)