Protein Alignment CG32301 and Adcy2

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_112269.2
• Gene: Adcy2 / 81636
• RGDID: 619965
• Length: 1095
• Species: Rattus norvegicus
• Alignment Length: 1189
• Identity: 312/1189 - (26%)
• Similarity: 521/1189 - (43%)
• Gaps: 257/1189 - (21%)

  Fly    22 EWKLLRYKCRELRLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVI--LLFSVVKNIDFLTVLP- 83
            :|....|.|...:         |.:.|.|:  ||::...|.|:.|.  |...|..::.||..:|
  Rat    35 DWLYESYYCMSQQ---------HPLIVFLL--LIVMGACLALLAVFFALGLEVEDHVAFLITVPT 88

  Fly    84 ----YFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDLILPIC------YFRPF-S 137
                :||:.:|                    :.:..:...||....|::.||      .|..| .
  Rat    89 ALAIFFAIFIL--------------------VCIESVFKKLLRVFSLVIWICLVAMGYLFMCFGG 133

  Fly   138 LVPSYDHV-----VIVLIYLMFP-------IAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDK 190
            .|.::|.|     :|.::|.|.|       ||.:....::.:.|:|      |::....... ..
  Rat   134 TVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIASILTSSSHTIVLSV------YLSATPGAKE-HL 191

  Fly   191 VWELTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQ----VVYQNLVFQMAMKEEKALLDSII 251
            .|::.| ...:|....|.   ..:.::.|...:...|:    .:...:..:...::::.||.|::
  Rat   192 FWQILA-NVIIFICGNLA---GAYHKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLL 252

  Fly   252 PVTLARSLQDAIASHIEEDPSNLMPFTKTRH-LFMEPHPEVSILEADMVDFTGLTTTMEVSDLVA 315
            |..:|..::..|...::...:..|..|...| |:::.|..||||.||:|.||.|.:.....:||.
  Rat   253 PAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVH 317

  Fly   316 ILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNK 380
            :|:|||..||..|..|...|||.|||.|.||:|:|...|.||..||...|||.|..::|......
  Rat   318 MLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGV 382

  Fly   381 KIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEE 445
            .|::|:|||||.:|.|:|||.|||:|:||.||.:.|.:|:.|:||.|||||.||..|:..|..||
  Rat   383 DINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEE 447

  Fly   446 GTDTAKLDPLLQRSNLSTYLI-------RSRLPNFEDTDDLED----DNFSLNDYRFSFSFSQDY 499
            | |....||.|::..:.||.:       ||....|.....|:.    .:..:..|..|:..::.:
  Rat   448 G-DGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPF 511

  Fly   500 EDIQVKAQRDMI------LEVEHMPV------NRVQTCKIRRPMHRIAKEDINEE---------- 542
            ..:.   .||.:      :....:|:      ||....|.::   :..:|::||.
  Rat   512 AHLH---HRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQK---KRFEEELNERMIQAIDGINA 570

  Fly   543 -----------------YRFHLESYYLFTTFRSWRMEWSFNKMRDLLMKY--SLGMMVFAGATII 588
                             |..::|..|..|...::              ||  :...::|....|:
  Rat   571 QKQWLKSEDIQRISLLFYNKNIEKEYRATALPAF--------------KYYVTCACLIFLCIFIV 621

  Fly   589 AMDLLVKSEAMDY-------TMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLSRWFIK 646
            .:.:|.|:..:.:       :::|.||:.....||..|.|             ..|..:  |.:|
  Rat   622 QILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKK-------------ASTSLM--WLLK 671

  Fly   647 ASDLIEKSVFVRIPLAI--------MVLFLLYVMSSE---TVFSCDIARLELEIINSELHNLRPQ 700
            :|.:|....:.||.|.|        |.:|.::.:|:.   |:.:.:.:...:.:.:::...|..:
  Rat   672 SSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANTSNANVSVPDNQASILHAR 736

  Fly   701 MLCFMPWGVTYAVVIVLS----------LMLVIIGIPLIIKLGVGLAILGSHVITVHAYYGFAFE 755
            .|.|:|:.:...::.::|          |.::|:.:.|:   |....:|.:|...:.||....|:
  Rat   737 NLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALV---GYNTILLHTHAHVLDAYSQVLFQ 798

  Fly   756 RSQTTNIGVTSSL--AHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEKKHELTKVKTRTIKI 818
            |.     |:...|  ..|..:..|||.::|......|..:..:.....|:|:.|..:......::
  Rat   799 RP-----GIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRV 858

  Fly   819 IMANILPTHVAEVFKVRR-RSDQLYYENFSQVAVMFATIENY-------EADKSG---LRALHEM 872
            ::.|:||.||||.|..|. ::::||::::..|.||||:|.::       :.:|.|   ||.|:|:
  Rat   859 LLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEI 923

  Fly   873 ICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFA 937
            |..||:|| :...:..:||||.:|.||:||.||.         ::|...:.:..:.|.
  Rat   924 IADFDDLL-SKPKFSGVEKIKTIGSTYMAATGLS---------AIPSQEHAQEPERQY------- 971

  Fly   938 PMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIA 1002
                       :|            |..|.|||..|:..| |..:|..|  .|.|    |::||.
  Rat   972 -----------MH------------IGTMVEFAYALVGKL-DAINKHSF--NDFK----LRVGIN 1006

  Fly  1003 HGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDFNIRCTYRGMTFVKG 1067
            ||||:|||:|..||.|||||:|||:||||.||||.|.|.|||.|:.:|:.....||.||:..|||
  Rat  1007 HGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKG 1071

  Fly  1068 VGQVPTYLVDLDENLHFQQ 1086
            .|.:.||.|:.:.:....|
  Rat  1072 KGDLKTYFVNTEMSRSLSQ 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	76/155 (49%)
		CYCc	812..1051	CDD:214485	89/249 (36%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	91/244 (37%)
Adcy2	NP_112269.2	AC_N	<37..264	CDD:318454	48/268 (18%)
		Guanylate_cyc	285..469	CDD:306677	86/184 (47%)
		DUF1053	499..603	CDD:399378	15/109 (14%)
		Guanylate_cyc	882..1081	CDD:306677	91/245 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.970