Protein Alignment CG32301 and Adcy3

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_570135.2
• Gene: Adcy3 / 64508
• RGDID: 71009
• Length: 1144
• Species: Rattus norvegicus
• Alignment Length: 1208
• Identity: 309/1208 - (25%)
• Similarity: 504/1208 - (41%)
• Gaps: 316/1208 - (26%)

  Fly    35 LEGVY------HRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDFLTVLPYFAVMLLTPS 93
            ||.:|      .||..|:       :::|...|...:|:::.:||.:.|.|..|....|.|:...
  Rat    62 LENLYQTYFKRQRHETLL-------VLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGVGLVLDI 119

  Fly    94 I--------LMPSREPNVEQYESIAILVSCLMALLLTAM----------------DLILPICYF- 133
            |        |:|.|....        :|..|:.||:||.                |.:....:|
  Rat   120 ILFVLCKKGLLPDRVSRK--------VVPYLLWLLITAQIFSYLGLNFSRAHAASDTVGWQAFFV 176

  Fly   134 ------RPFSLVPSYDHVVIVLIYLMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDKVW 192
                  .|.||.|      ||:|.::..:.     ....||:.|:      ....|::..:..:.
  Rat   177 FSFFITLPLSLSP------IVIISVVSCVV-----HTLVLGVTVA------QQQQDELEGMQLLR 224

  Fly   193 ELTAYGAYLFFLNMLCMFLSRFQEYNM-----RSGILSRYQVVYQNLVFQMAMKEEKALLDSIIP 252
            |:.| ..:|:    ||..:.....|.|     |...|...|.:...:..:...::::.|:.||:|
  Rat   225 EILA-NVFLY----LCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILP 284

  Fly   253 VTLA-RSLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAI 316
            ..:| ..|:|......::|....      ..::|..|..||||.||:|.||.|::.....:||.:
  Rat   285 KHVADEMLKDMKKDESQKDQQQF------NTMYMYRHENVSILFADIVGFTQLSSACSAQELVKL 343

  Fly   317 LHELFVSFD-LAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNK 380
            |:|||..|| |||.::: .|||.|||.|.|:.|:|.|...||...:...|.|:|....|.::...
  Rat   344 LNELFARFDKLAAKYHQ-LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKT 407

  Fly   381 KIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEE 445
            .:|:|:|||:|.:|.|::|..:||:|:||.||.:.|::|:.|:||.||||..|:..|...:..|.
  Rat   408 GVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEP 472

  Fly   446 GTDTAKLDPLLQRSNLSTYLI----------------RSRLPN---------------------- 472
            |...::.| .|....:.||||                .|.|||
  Rat   473 GDGGSRCD-YLDEKGIETYLIIASKPEVKKTAQNGLNGSALPNGAPASKPSSPALIETKEPNGSA 536

  Fly   473 ------FEDTDDLE--DDNFSLNDYRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCKIRR 529
                  .|:.::.|  .||.|..:.|..... ||..|..|.|..|     ||.....:....:.|
  Rat   537 HASGSTSEEAEEQEAQADNPSFPNPRRRLRL-QDLADRVVDASED-----EHELNQLLNEALLER 595

  Fly   530 PMHRIAKEDINEEYRFHLESYYLFTTFRSWRME--WSFNKMRDLLMKYSLGMMV-FAGATIIAMD 591
            ...::.|:         ..::.|...|....||  :|..|.:.....:|...:| |..|.:   :
  Rat   596 ESAQVVKK---------RNTFLLTMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLFCTAMV---E 648

  Fly   592 LLVKSEAMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVF 656
            :|:....|...:.|.:..::||.|.:.|...::.|.            ..:..:..|..|:::.:
  Rat   649 ILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRA------------FPKKLVAFSSWIDRTRW 701

  Fly   657 VRIPLAIMVLFLLYVMSSETVFSCDIARLELEIINSELHNLRPQMLCFM-PWGVT---------- 710
            .|...|::.:|:|.:.:...:.||                    :..:| |:.||
  Rat   702 ARNTWAMLAIFILVMANVVDMLSC--------------------LQYYMGPYNVTTGIELDGGCM 746

  Fly   711 -----YAVVIVLSLM--LVIIGIPLIIKLGVGLAILGSHVITVHAYYGF---------------- 752
                 |..|.||||:  ::::.:..::||.:.|.:.|:  :|....|.:
  Rat   747 ENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGA--VTAINLYAWCPVFDEYDHKRFQEKD 809

  Fly   753 ----AFERSQ---TTNIGVTSS---LAHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEK--- 804
                |.|:.|   |..:..|.|   |..|.|.:...:.|::    |::     |:.|...||
  Rat   810 SPMVALEKMQVLSTPGLNGTDSRLPLVPSKYSMTVMMFVMM----LSF-----YYFSRHVEKLAR 865

  Fly   805 -----KHELTKVKTRTIKI------IMANILPTHVAEVF-KVRRRSDQLYYENFSQVAVMFATIE 857
                 |.|:...|.|..::      ::.|:||.|||..| ..::|.::||.:::.::.||||::.
  Rat   866 TLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLP 930

  Fly   858 NY------EADKSG----LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTD 912
            |:      |:..:|    ||.|:|:|..||.||.| ..:..|.|||.:|.||:||.|:..|
  Rat   931 NFADFYTEESINNGGIECLRFLNEIISDFDSLLDN-PKFRVITKIKTIGSTYMAASGVTPD---- 990

  Fly   913 FSVSVPISTN--RESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLR 975
                  ::||  ..|.|.:||...|:.       .:.||                 .:|||.:..
  Rat   991 ------VNTNGFTSSSKEEKSDKERWQ-------HLADL-----------------ADFALAMKD 1025

  Fly   976 ILRDIRSKGI--FFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRD 1038
            .|.:|.::..  |.         |:||:..|.|:|||:|..||||||||:|||:||||.||||..
  Rat  1026 TLTNINNQSFNNFM---------LRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMG 1081

  Fly  1039 GIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLV 1076
            .|.|.|.|..:||::..|...||..||||.|::.|:.:
  Rat  1082 NIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFL 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	67/156 (43%)
		CYCc	812..1051	CDD:214485	87/259 (34%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	88/248 (35%)
Adcy3	NP_570135.2	AC_N	<44..303	CDD:318454	56/277 (20%)
		Guanylate_cyc	310..494	CDD:306677	75/185 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..563		9/58 (16%)
		Guanylate_cyc	914..1121	CDD:306677	88/250 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900