DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and Gucy1a1

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_001343916.1	Gene:	Gucy1a1 / 60596	MGIID:	1926562	Length:	691	Species:	Mus musculus

Alignment Length:	459	Identity:	99/459 - (21%)
Similarity:	172/459 - (37%)	Gaps:	122/459 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KNIDFLTVLPYF---AVMLLTPSILMPSREPNVEQYESIAILVSCLMA----------LLLTA-- 123
            |:.|||.|..:|   ...||.|.|:..:.....|.:..::::..|..:          ||.:.
Mouse   195 KDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSDCTEFVNQPYLLYSVHV 259

  Fly   124 -------------MDLILPICYF-----------------------------RPFSLVPSYDHVV 146
                         ..|::|...|                             |.|...|:::...
Mouse   260 KSTKPSLSPGKPQSSLVIPASLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFEEFF 324

  Fly   147 IVL----------IYLMFPIAFV-----------KNGRAYFLGLAVSLFYFGYMALIDKISTL-- 188
            .:|          |..|..:.||           |:.|...|.        |.|..|.:.|.:
Mouse   325 EILTPKINQTFSGIMTMLNMQFVIRVRRWDNSVKKSSRVMDLK--------GQMIYIVESSAILF 381

  Fly   189 ------DKVWELTAYGAYLFFL---NMLCMFLSRFQEYNMRSGILSRYQVVYQNLVF-QMAMKEE 243
                  |::.:.|..|.||..:   |.|...:...::...:.|:..|...:...|.. ..|::||
Mouse   382 LGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEE 446

  Fly   244 KA----LLDSIIPVTLARSL-QDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTG 303
            |.    ||.||.|..:|:.| |..|..                   .:...||::|.:|:|.||.
Mouse   447 KKRTVDLLCSIFPSEVAQQLWQGQIVQ-------------------AKKFSEVTMLFSDIVGFTA 492

  Fly   304 LTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMI 368
            :.:......::.:|:.|:..||.........:::.:||:|....|:.....|||......||.|:
Mouse   493 ICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMM 557

  Fly   369 EISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRT 433
            |:|.||.....:.|.:|||:|||.:.||::|:...::.::..:|.:.|:.||..:|..:::|..|
Mouse   558 ELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622

  Fly   434 LGLL 437
            ..||
Mouse   623 YRLL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	44/155 (28%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	37/196 (19%)
Gucy1a1	NP_001343916.1	Guanylate_cyc	472..643	CDD:306677	44/174 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900