Protein Alignment CG32301 and adcy3a

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: XP_009290286.1
• Gene: adcy3a / 571825
• ZFINID: ZDB-GENE-111027-6
• Length: 1119
• Species: Danio rerio
• Alignment Length: 1180
• Identity: 289/1180 - (24%)
• Similarity: 496/1180 - (42%)
• Gaps: 319/1180 - (27%)

  Fly    82 LPYFAVMLLTPSILMPSREPNV-------EQYESIAILV------SCLMALLLTAM---DLILPI 130
            ||.|..:...|..|     .|:       :::|::.:||      .|.:.::.|.:   |.:..:
Zfish    49 LPRFMRLTFAPDSL-----ENLYQTYFRRQRHETLLVLVVFAALFDCYIIVMCTVLYTADKLASV 108

  Fly   131 CYFRPFSLVPSYDHVVIVLIYL-----MFPIAFVKNGRAYFLGLAVSLFYFGYMAL--------I 182
            .       |.|......||:||     :.|....:....|.|.:.::...|.|:.|        .
Zfish   109 A-------VASVGLAADVLLYLLCRYGLLPDRVTRRLVPYALWVLIAAQIFCYLGLNFARFHQPS 166

  Fly   183 DKISTLDKVWELTAYGAYLFFLNM---------------------LCMFLSRFQEYNMRSGILSR 226
            |.:.     |:  |:.::.|||.:                     |.:.:::.|:.:::...|.|
Zfish   167 DTVG-----WQ--AFFSFSFFLTLPLRLTPIVLITSVSCGVHTLVLGVTIAQQQQEDIQGAALGR 224

  Fly   227 Y----QVVY--------------------------QNLVFQMAMKE----EKALLDSIIPVTLA- 256
            .    .|:|                          |:|..::.::|    ::.||.||:|..:|
Zfish   225 QLLANMVIYVCAITVGVMSYYMADRKHRKAFLEARQSLEVKLNLEEQSQQQERLLLSILPKHIAD 289

  Fly   257 RSLQD--AIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHE 319
            ..|||  ..||..|....|.|        :|..|..||||.||:|.||.|:::....:||.:|:|
Zfish   290 EMLQDMKKEASQKEMQQFNTM--------YMYRHENVSILFADIVGFTQLSSSCSAQELVKLLNE 346

  Fly   320 LFVSFD-LAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKID 383
            ||..|| |||.::: .|||.|||.|.|:.|:|.|...||...:...|.|:|....|.::....:|
Zfish   347 LFARFDKLAAKYHQ-LRIKILGDCYYCICGLPDYREDHAACSIMMGLAMVEAISYVREKTQTDVD 410

  Fly   384 LRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTD 448
            :|:|||||.:|.|::|..:||:|:||.||.:.|::|:.|:||.||||..||..|...:..|.|..
Zfish   411 MRVGVHSGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQNTLECLHGEFDVEPGNG 475

  Fly   449 TAKLDPLLQRSNLSTYL---------------------------------------IRSRLPNFE 474
            ..:.:.|.:| .:.|||                                       :.:.....|
Zfish   476 GDRCEYLKER-GIETYLVVLPKGPVGKNGINGVKLSVTSSNGNSPLLINTTECNGSVHTACTTPE 539

  Fly   475 DTDDLE----DDNF-------SLNDYRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCKIR 528
            |.::|:    :.:|       .|.|.......:|:.|....|...:.:||.|     .||..| .
Zfish   540 DPEELDTRVVNPSFPNPRRRLRLRDLAERVIDAQENEQELNKLLNEALLERE-----TVQALK-G 598

  Fly   529 RPMHRIAKE--DINEEYRFHLESYYLFTTFRSWRMEWSFNKMRDLLMKYSLGMMVFAGATIIAMD 591
            :..:|::..  |...|.||.:|.                .|........|..:::|..    .|:
Zfish   599 KYTNRLSLRFTDPELETRFSVEK----------------EKQSGAAFSCSCVVLLFTA----VME 643

  Fly   592 LLVKSEAMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVF 656
            .|:....:...:..::..::||.|.:.|...::           |..|..| .:..|..|:.:.:
Zfish   644 ALIDPWLVANYVTLAVGEVLLLILTICSLAAIF-----------PRVFPKR-LVSFSTWIDHTRW 696

  Fly   657 VRIPLAIMVLFLLYVMSSETVFSC---DIARLELEIINSELHNLR-----PQMLCFMPWGVTYAV 713
            .|...|:..:|::.:.....:.||   ..:.:|...:...:..:|     |:.         |:.
Zfish   697 ARNTWAMAAIFIVTLADIVDMLSCRAPQTSTVESTAVPPVVTAIRGCAENPKY---------YSF 752

  Fly   714 VIVLSLM--LVIIGIPLIIKLGVGLAI-LGSHVITVHAYYGFAFERSQTTNI-GVTS------SL 768
            :.||:|:  .:::.:..::||.:.|.| :.:..:.::::       |||.:: .:|.      :|
Zfish   753 IAVLALIATTMLVQVSHMVKLTLMLLITVATGAVNIYSW-------SQTFDLYDLTRFKEYRVNL 810

  Fly   769 AHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEK--------KHELTKVKTRTIKI------I 819
            ..|.|.::..|.:         ::.:.|:.|...||        |.|:.:.|.:..::      :
Zfish   811 VPSKYTMSVMIFI---------MMVSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYEMRRWNEAL 866

  Fly   820 MANILPTHVAEVF-KVRRRSDQLYYENFSQVAVMFATIENY------EADKSG----LRALHEMI 873
            :.|:||.|||..| ..::|.::||.:::.::.||||:|.|:      |:..:|    ||.|:|:|
Zfish   867 VTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEII 931

  Fly   874 CYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAP 938
            ..||.||...| :..|.|||.:|.||:||.|:..|:.|:                      .:|.
Zfish   932 SDFDSLLDEPQ-FRCITKIKTIGSTYMAASGVTSDNNTN----------------------GYAC 973

  Fly   939 MDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDI--RSKGIFFEKDSKLTGSLKIGI 1001
            |..:||          :..|....:..:.:|||.:...|.:|  :|...|.         |:||:
Zfish   974 MKKEEI----------SDRERWQHLADLADFALAMKVTLMNINYQSFNNFM---------LRIGL 1019

  Fly  1002 AHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDFNIRCTYRGMTFVK 1066
            ..|.|:|||:|..|||:||||:|||:||||.||||...|.|.|....:|:|:..|...||..|||
Zfish  1020 NKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFRFVRRGPIFVK 1084

  Fly  1067 GVGQVPTYLV 1076
            |.|::.||.:
Zfish  1085 GKGELLTYFL 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	69/156 (44%)
		CYCc	812..1051	CDD:214485	83/257 (32%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	86/246 (35%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831	50/273 (18%)
		CYCc	273..468	CDD:214485	83/203 (41%)
		Guanylate_cyc	310..492	CDD:278633	76/191 (40%)
		CYCc	858..1075	CDD:214485	84/258 (33%)
		Guanylate_cyc	889..1096	CDD:278633	86/248 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900