Protein Alignment CG32301 and adcy3b

DIOPT Version :10

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: XP_068071803.1
• Gene: adcy3b / 564719
• ZFINID: ZDB-GENE-041014-276
• Length: 1071
• Species: Danio rerio
• Alignment Length: 1152
• Identity: 307/1152 - (26%)
• Similarity: 515/1152 - (44%)
• Gaps: 226/1152 - (19%)

  Fly    19 PGYEWKLLRYKCRELR-----LEGVYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDF 78
            ||....|||:  ..||     ||.:|..: .|........::||...|...:||::.:||.:.|.
Zfish    30 PGVCPSLLRF--LRLRFTPESLEKIYQTY-FLRQRQETLLVLIVFAALFNGYVIIMCAVVYSPDK 91

  Fly    79 LTVLPYFAVMLLTPSIL-MPSREPNVEQYESIAILVS-CLMALLLTAMDLILPICYFR------- 134
            |..|...|..|.:..:| :.||      :..:.:.|| ||:...|..:.::..:|||.
Zfish    92 LNTLAVAAGGLASDILLYITSR------FRLLPVHVSACLVPYALWLLIMVHVLCYFSLNFAGFY 150

  Fly   135 --------------------PFSLVPSYDHVVIVLIYLMFPIAFVKNGRAYFLGLAVSLFYFGYM 179
                                |..|.|      |||:.:     |........||..:||
Zfish   151 AAGDTVGWQTFFIFSFFLTLPLPLAP------IVLLSV-----FSCCAHTLLLGFTISL------ 198

  Fly   180 ALIDKISTLDKVWELTAYGAYLFFLNMLCMFLSRFQ-EYNMRSGILSRYQVVYQNLVFQMAMKEE 243
            ...||:.....:.:|.| ...|:|..||...:|.|. :...|:..|...|.:..:|..:...:::
Zfish   199 RNQDKLQLSVLIRQLVA-NLMLYFGAMLVGVMSYFMADRKYRTAFLEAKQSLEVSLTLKEQSQQQ 262

  Fly   244 KALLDSIIPVTLARSLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTM 308
            :.||.||:|    :.:.|.:...:::..:......:...::|..|.:||||.||:|.||.|::.:
Zfish   263 EELLLSILP----KHIADEMLQGMKKGANQKTDAQQFNTMYMYRHEDVSILFADIVGFTQLSSAV 323

  Fly   309 EVSDLVAILHELFVSFD-LAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISR 372
            ...:||.:|:|||..|| |||.|:: .|||.|||.|.|:.|:|.|...||...:...|.|:|...
Zfish   324 TPKELVKVLNELFARFDKLAAQHHQ-LRIKILGDCYYCICGLPDYREDHAACSIMMGLSMVEAIS 387

  Fly   373 EVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLL 437
            .|.::....:|:|:|||||.:|.|::|..:||||:||.||.:.|::||.|:||.||||..|...|
Zfish   388 YVREKTQTGVDMRVGVHSGTVLGGVLGQKRWQFDVWSTDVTVANKMESGGIPGRVHISQSTKDCL 452

  Fly   438 DNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLEDDNFSLNDYRFSFSFSQDYED- 501
            .:.:..|||....:.|.||:: .:.|||: ........|:.:.:... :|....|.|.....|:
Zfish   453 HDEFELEEGNGGERCDYLLEK-GIDTYLV-VMAKETAKTNGVGNGTV-INTSGSSTSVKNTAEES 514

  Fly   502 ----IQVKAQRDMILEVEHMPVNRVQTCKIRRPMHRIAKEDINE--EYRFH---LESYYLFTTFR 557
                :|:.:..:..:|.||:  |.:....:.|....|.:|....  ..||.   |||.|
Zfish   515 ETQHLQLPSITEEGMEEEHL--NLLSKTLLEREAEEILEEKKTSALSLRFEDPDLESRY------ 571

  Fly   558 SWRMEWSFNKMRDLLMKYS--LGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLASY 620
                  |..|.|...:.:|  ..:::|..    ||::|:..:.:...:..::..|:||.|.|.|.
Zfish   572 ------SAEKERQTGVAFSCCCAVLIFTS----AMEILIDPQLIVNYVTLAIGELLLLILTLCSL 626

  Fly   621 KKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCDIARL 685
            ..::           |..| ||..:..|..|:::.:.|...|:..:|:|.:.....:.||  .:.
Zfish   627 AAVF-----------PRVF-SRRLVSFSQWIDRTRWARNTWAMAAIFVLTMAEVADMLSC--VQP 677

  Fly   686 ELEIINSELHNLRPQMLCFMPWGVT---------------YAVVIVLSLMLVIIGIPL--IIKLG 733
            .|.::||..             |||               |..:.||||:..::.:.|  ::||.
Zfish   678 PLLLLNSSS-------------GVTLESLGNGGCAENPKHYGYISVLSLVATVMLVQLSHVVKLA 729

  Fly   734 VGLAI-LGSHVITVHAY------YGFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNYI 791
            :.|.: :.:..:.:|::      |.|      ...:....|:..:.|::...|::::. |:..:.
Zfish   730 LMLLVTIATGAVNIHSWMYIYDIYDF------IRYLDYRYSVVPTRYLLTVMIIIMML-GFYYFA 787

  Fly   792 LKASYFMSMCFEKKHELTKVKTRTIKI------IMANILPTHVAEVF-KVRRRSDQLYYENFSQV 849
            ..........|..|.|:|..|.:..::      ::.|:||.|||:.| ..::|.::||.:::.::
Zfish   788 RHVERQSRKLFLWKIEVTDQKEKVYEMRTYNEALVTNMLPEHVAKHFLGSKKRDEELYSQSYDEI 852

  Fly   850 AVMFATIENY------EADKSG----LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACG 904
            .||||:|.|:      |:..:|    ||.|:|:|..||.|| :...:..|.|||.:|.||:||.|
Zfish   853 GVMFASIPNFSDFYTEESINNGGLECLRILNEIISDFDSLL-DRTEFRHITKIKTIGSTYMAASG 916

  Fly   905 LHVDHYTDFSVSVPISTNRESDKLQKSGSV-----RFAPMDGDEIMIKDLHPTQATTNEDDNTIL 964
                      |:...:||..:|:..:..|:     .||.
Zfish   917 ----------VTPESNTNGYADRKIEDQSLLDRWQHFAD-------------------------- 945

  Fly   965 VMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMAS 1029
             :.:|||.:..:|.::       .|.|.....|:||:..|.|:|||:|..|||:||||:|||:||
Zfish   946 -LADFALAMKVMLGNL-------NKQSFNNFMLRIGLNKGSVLAGVIGARKPHFDIWGNTVNVAS 1002

  Fly  1030 RMTSTGVRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLV 1076
            ||.||||...|.|.|...|:|:::..|...||..:|||.|::.|:.:
Zfish  1003 RMESTGVMGNIQVVEDCYNILKEYGFRFVRRGPIYVKGKGELLTFFM 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	125/424 (29%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	71/156 (46%)
		AcyC	681..1076	CDD:441717	117/440 (27%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	82/249 (33%)
adcy3b	XP_068071803.1	AcyC	95..460	CDD:441717	116/393 (30%)
		Guanylate_cyc	298..460	CDD:425528	71/162 (44%)
		AcyC	627..1048	CDD:441717	129/499 (26%)
		Guanylate_cyc	844..1051	CDD:425528	82/251 (33%)