Protein Alignment CG32301 and adcy2a

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: XP_692173.5
• Gene: adcy2a / 563724
• ZFINID: ZDB-GENE-061109-1
• Length: 1155
• Species: Danio rerio
• Alignment Length: 1150
• Identity: 303/1150 - (26%)
• Similarity: 490/1150 - (42%)
• Gaps: 217/1150 - (18%)

  Fly    39 YHRHCHLVSVALVTQLIIVIEILMLIHVILL--FSVVKNIDFLTVLPYFAVMLLTPSILMPSREP 101
            |||......:.:...||::...|.|:.|...  ..:..::.|:..:|....:.||..:|
Zfish    96 YHRMSQQHPLIVFLLLIVMGACLALLAVFFASGLDIEDHVAFVITVPTALAIFLTIFVL------ 154

  Fly   102 NVEQYESIAILVSCLMALLLTAMDLILPIC-----YFRPF--SLVPSYDHV-----VIVLIYLMF 154
                     :.:..:...||....|::..|     |...|  .::..:|.|     :|.::|.|.
Zfish   155 ---------VCIESVFKKLLRVFSLVIWGCLVAMGYLFMFFGGIICPWDQVSFFLFIIFVVYTML 210

  Fly   155 P-------IAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTAYGAYLFFLNMLCMFLS 212
            |       ||.|....::.:.|:|.|     .:.:..:..|  ||::.| ...:|....:.   .
Zfish   211 PFSMRDAIIASVLTASSHTVVLSVCL-----SSTVSHVEPL--VWQILA-NVIIFICGNVA---G 264

  Fly   213 RFQEYNMRSGILSRYQ----VVYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSN 273
            .:.::.|...:...||    .:...:..:...::::.||.|::|..:||.::..|...::.....
Zfish   265 AYHKHLMELALKQTYQDTCNCIKSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGPKFG 329

  Fly   274 LMPFTKTRH-LFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIK 337
            .:..|...| |:::.|..||||.||:|.||.|.:.....:||.:|:|||..||..|..|...|||
Zfish   330 QVENTNNFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIK 394

  Fly   338 FLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTK 402
            .|||.|.||:|:|...|.||..||...|||.|..::|......:|.:|:|||||.:|.|:|||.|
Zfish   395 ILGDCYYCVSGLPESLPNHAKNCVKMGLDMCEAIKKVRDATGVEISMRVGVHSGNVLCGVIGLQK 459

  Fly   403 WQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLI- 466
            ||:|:||.||.:.|.:|:.|:||.|||:|.||..|:..|..|:|....: ||.|:...:.|||:
Zfish   460 WQYDVWSHDVTLANHMEAGGVPGRVHITSETLEHLNGAYKVEDGHGQER-DPYLKEHGVITYLVI 523

  Fly   467 -------------RSR--------------------------LPNFEDTDDLEDDNFSLN----- 487
                         |.|                          ..|....|.:.::|..:|
Zfish   524 NPKVERKSPQHYYRPRHTIDGAKMRASVRMTRYLESWGAAKPFANLHHRDSMTNENGKINTADVP 588

  Fly   488 --DYRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCK-IRRPMHRIAKEDINE-EYRFH-- 546
              .|.|      .....:.|:|:...  .|.:....::|.. |......:..|||.. ...||
Zfish   589 IGQYHF------QRRSERTKSQKKRF--EEELNERMIRTFDGINSQKQWLKSEDIQRISLFFHNK 645

  Fly   547 -LESYYLFTTFRSWRMEWSFNKMRDLLMKYSLGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLL 610
             ||..|..||..::              ||.:.........|..:.:||..:.....:.|.:..|
Zfish   646 ALEKEYRATTLPAF--------------KYYITCACLIFFCIFIVQILVLPKTAILGVSFGMSFL 696

  Fly   611 ILLPLLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSE 675
            ||..:||..:...:|:.::.:..:..      |.:::|.:|....:.||.|.:....|:.:|:..
Zfish   697 ILSVILLVCFIGHFLQCKKTASASWV------WILRSSGIIASKPWPRITLTMATTALILIMAVF 755

  Fly   676 TVFSCD--IARLELEIINSELHNLRP--QMLCFMPWGVTYAVVIVLSLMLVIIGIPLIIKLGVGL 736
            .:|..:  :..:|.....|....|:|  |.:.::.....|....:.|.:|.:|...:.:::...|
Zfish   756 NMFFIEDNLTLMETVYNTSNETLLQPDGQPIPYLDKNTFYLPYFIYSCILGLISCSVFLRINYEL 820

  Fly   737 --------------AILGSHVITVHAYYGFAFERSQTTNIGVTSSL--AHSWYMVAFFIVVVVRE 785
                          .||.:|...:..|..|.::.......||...|  ..|..:..|||.::|..
Zfish   821 KMLIMLTAVVLYSVIILQTHASLLDEYSKFLYKTEVIERPGVLKDLKTMGSVSLFIFFITLLVLA 885

  Fly   786 GYLNYILKASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVRR-RSDQLYYENFSQV 849
            ....|..:..:.....|:|:.|..:......::::.|:||.||||.|..|. :::.||::::..|
Zfish   886 RQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLARNWKNEDLYHQSYDLV 950

  Fly   850 AVMFATIENY-------EADKSG---LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACG 904
            .||||:|.::       :.:|.|   ||.|:|:|..||||| :...:..:||||.:|.||:||.|
Zfish   951 CVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELL-SKPKFSGVEKIKTIGSTYMAATG 1014

  Fly   905 LHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTIL---VM 966
            |:..                                          |....|.|.|...:   .|
Zfish  1015 LNAT------------------------------------------PGPEYTQEHDRQYMHIGTM 1037

  Fly   967 TEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRM 1031
            .|||..|:..| |:.:|..|  .|.|    |::||.||||.|||:|..||.|||||:|||:||||
Zfish  1038 VEFAFALVGKL-DVINKHSF--NDFK----LRVGINHGPVKAGVIGAQKPQYDIWGNTVNVASRM 1095

  Fly  1032 TSTGVRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLV 1076
            .||||...|.|||.|:.:|:.....|:.||:..|||.|::.||.|
Zfish  1096 DSTGVLGKIQVTEETSCILQTLGYTCSCRGIINVKGKGELKTYFV 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	75/155 (48%)
		CYCc	812..1051	CDD:214485	89/252 (35%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	90/247 (36%)
adcy2a	XP_692173.5	AC_N	<92..319	CDD:292831	45/248 (18%)
		CYCc	295..498	CDD:214485	84/202 (42%)
		Guanylate_cyc	340..524	CDD:278633	84/184 (46%)
		DUF1053	554..658	CDD:283888	21/111 (19%)
		CYCc	912..1120	CDD:214485	90/257 (35%)
		Guanylate_cyc	942..1141	CDD:278633	90/248 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.970