Protein Alignment CG32301 and adcy5

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_001165056.1
• Gene: adcy5 / 562619
• ZFINID: ZDB-GENE-081104-470
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1139
• Identity: 283/1139 - (24%)
• Similarity: 510/1139 - (44%)
• Gaps: 198/1139 - (17%)

  Fly    29 KCRELRLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDFLT-VLPYFAVMLLTP 92
            |.:..:||.:|.|:...::.:.:|.|:.|  ::::..|:|.|.....:..|| ||.:.|.::|..
Zfish   150 KFQSEKLERLYQRYFFRLNQSSLTMLMAV--LVLVCAVMLGFHCAGGMCQLTFVLVFTAAIVLIL 212

  Fly    93 SILMPSREPNVEQYESIAILVSCLMALLLTAMDLILPICYFRPFSLVPSYDHVV--IVLIYLMFP 155
            ::::..   |...:....:.:.|.:.:||.....::.:.:.:|.|........|  |.:||.:.|
Zfish   213 TLMVVC---NRNSFHQDHMWIVCYLLILLVLAVQVVGVLFVKPRSASEGIWWTVFFIHVIYTLLP 274

  Fly   156 IAFVKNGRAYFLGLAVSLFYFGYMALID-KISTLDK-VWELTAYGAYLFFLNMLCMFLSRF-QEY 217
               |:...|...|:.:|..:    .||. :::.:|. :|:.......:|..:.:....:.: .|.
Zfish   275 ---VRMRAAVITGIILSAIH----VLISWRLNDMDVFLWKQLVSNVLIFSCSNIVGVCTHYPAEG 332

  Fly   218 NMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSNLMPFTKTRH 282
            :.|.......:.:...|..|...::::.||.|::|..:|..::..|.:..|:     |.|.|
Zfish   333 SQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVALEMKADINAKQED-----MMFHK--- 389

  Fly   283 LFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVT 347
            ::::.|..||||.||:..||.|.:.....:||..|:|||..||..|..|...|||.|||.|.||:
Zfish   390 IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVS 454

  Fly   348 GIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDV 412
            |:|.....||:.||...:||||....|.:.....:::|:|:|||.:..|::||.|||||:||.||
Zfish   455 GLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDV 519

  Fly   413 DITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLI----------R 467
            .:.|.:|:.|..|.:||:..||..|:..|..|.|:. .:.:..|::.|:.||||          :
Zfish   520 TLANHMEAGGKAGRIHITKATLNYLNGDYDVEPGSG-GERNVYLKKHNIETYLIVGCSQKRKEEK 583

  Fly   468 SRLP--NFEDTDDLEDDNFSLNDYRF-----SFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTC 525
            :.:.  |.:.|:.:..::....|..|     :.|.|::.:.:..:..:|...:....|.:.|...
Zfish   584 AMIAKMNRQRTNSVTHNSTHWTDRPFYNHLNANSVSKEMKRMGFEDPKDKNTQENLNPEDEVDEF 648

  Fly   526 KIR----RPMHRIAKEDINEEYRFHLESYYLFTTFRSWRMEWSFNKMRDLLMKYSLGMMVFAGAT 586
            ..|    |.:.|:..|        |::.:.|  |||...:|..::|..|    .|.|..|...:.
Zfish   649 LGRAIDARSIDRLRSE--------HVKKFLL--TFREPDLEKKYSKQVD----SSFGAYVACASL 699

  Fly   587 IIAMDLLVKSEAMDYT-MLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLSRWFIKA--- 647
            :......::...:.:: ::...::|.|:.|::..:...........||  |...||:..:::
Zfish   700 VFLFICFIQIIIVPHSGLMVGFYVLCLVVLMVVMFISAIYSCFGFFPI--PLQTLSKRIVQSRLN 762

  Fly   648 SDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCDIARLELEIINSELHNLRPQML---------- 702
            |.|:          .:..:.|:::.:...:|:|...  :|:....:..|:.|..:
Zfish   763 STLV----------GVFTIVLVFISAFINIFTCSTD--DLKTCLGQEFNISPSNVNACHAHFSSL 815

  Fly   703 -----------------CFMPWGVTYAVVIVLSLMLVIIGIPLIIKLGVGLAILGSHVITVHAYY 750
                             |..|...:..|::.|....|.:.:..|.||.:.|.|...:|:.:....
Zfish   816 NYTLWSQNRLCNSSSPTCNFPEYFSSCVLLSLLACSVFLQVSSIGKLFLMLFIEILYVLIMEVPE 880

  Fly   751 GFAFE--------RSQTTNIG-----------VTSSLAHSWYMVAFFIVV--VVREGYLNYILKA 794
            ...|:        .:...|.|           :.:.:..:.:::|.::..  |.....|:::.|.
Zfish   881 VSLFDNVDLLVMANALAPNNGTCIVDTRVPLKIVTPVVITVFVLALYLHAQQVESTARLDFLWKL 945

  Fly   795 SYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVR-RRSDQLYYENFSQVAVMFATIEN 858
                 ...|:|.|:.:::... :.::.||||..||..|..| ||:|:|||::...||||||:|.|
Zfish   946 -----QATEEKEEMEELQAYN-RRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISN 1004

  Fly   859 Y-------EADKSG---LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDF 913
            :       ||:..|   ||.|:|:|..||| :::...:.::||||.:|.||:||.||:...|
Zfish  1005 FSEFYVELEANNEGVECLRLLNEIIADFDE-IISEDQFRQLEKIKTIGSTYMAASGLNDSTY--- 1065

  Fly   914 SVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILR 978
                        ||..:|                  |            |..:.::|:.|:..::
Zfish  1066 ------------DKAGRS------------------H------------IRALADYAMRLMDQMK 1088

  Fly   979 DIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVT 1043
                   :..:.|.....:|||:..|||:|||:|..||.|||||:|||:||||.||||.:.|.||
Zfish  1089 -------YINEHSFNNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVT 1146

  Fly  1044 ESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLVD 1077
            .....||..:|....|||:..|||.|::.||.::
Zfish  1147 TDLYQVLSSYNYTLEYRGVVKVKGKGEMMTYFLN 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	66/155 (43%)
		CYCc	812..1051	CDD:214485	85/249 (34%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	85/244 (35%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831	49/254 (19%)
		CYCc	354..548	CDD:214485	76/201 (38%)
		Guanylate_cyc	390..574	CDD:278633	75/184 (41%)
		DUF1053	598..687	CDD:283888	18/98 (18%)
		CYCc	961..1155	CDD:214485	86/247 (35%)
		Guanylate_cyc	987..1181	CDD:278633	85/247 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000