DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and si:dkey-206f10.1

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	XP_009293230.1	Gene:	si:dkey-206f10.1 / 560719	ZFINID:	ZDB-GENE-041014-154	Length:	1187	Species:	Danio rerio

Alignment Length:	1157	Identity:	322/1157 - (27%)
Similarity:	509/1157 - (43%)	Gaps:	219/1157 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VDYRS-------LGN-MPGYEWKLLRYKCRELRLEGVYHRHCHLVSVALVTQLII--VIEILMLI 64
            |||.|       .|| :.|.....||:..:...||.:|.||.   |....|.|::  :|:....:
Zfish   111 VDYISDADFFVHWGNIIHGVHVPTLRHIFKSKDLEKLYQRHS---SHTRRTSLVVTNIIDAAAKL 172

  Fly    65 HVILLFSVVKNIDFLTVLP------------YFAVMLLTPSILM----PSREPNVEQYESIAILV 113
            |:.||        :|.:.|            :|....:...:|:    .|..|....|..:|..:
Zfish   173 HLFLL--------YLALAPDRSDILMSWFTGFFMACAIALCVLVLTCKRSHSPKWLHYAGMASWL 229

  Fly   114 SCLMALL-LTAMDLILPICYFRPFSLVPSYDHVVIVLIYLMFPIAFVKNGRAYFLGLAVSLFYFG 177
            |....:| ..|..|.....::..|:|..:|..:.:.|::            |...|...|:.:.
Zfish   230 SQTAQVLGGLAYGLERDQSWYVLFTLFATYTLLPLPLLW------------AIGAGTLTSILHL- 281

  Fly   178 YMALIDKISTLDKVWELTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVVYQNLVFQMAMKE 242
            ....|..||.:....:|.|.......:|:..:|:....:.:.|...|...:.:...:..:...:.
Zfish   282 TAETIRHISEVGLFRKLLAKALLYTSMNVAGLFIHYLTDRSQRQAFLETRRCIEGRMKLETENQR 346

  Fly   243 EKALLDSIIPVTLA-RSLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTT 306
            ::.|:.||:|..:| ..:.|..:...|.||..   |.|   :::..:.:||||.||:..||.|:.
Zfish   347 QERLVLSILPRFVALEMISDMTSMDDELDPQQ---FHK---VYIHQYKDVSILFADIKGFTLLSM 405

  Fly   307 TMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEIS 371
            .|...:||.:|:|||..||..|......|||.|||.|.||:|:|.....||..||...|.||...
Zfish   406 NMSAQELVRLLNELFGRFDRLAEEYDCLRIKILGDCYYCVSGVPEPQRAHARCCVEMGLAMISTM 470

  Fly   372 REVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGL 436
            |.:.|::|..:|:|||:|:|.:|.|::||.|||||:||.||.|.|.||:.|:||.:|||..||..
Zfish   471 RSLRKQQNFDMDMRIGIHTGSVLCGVLGLQKWQFDVWSWDVGIANMLEAGGIPGRIHISRATLDC 535

  Fly   437 LDNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLED----------DNFSLN-DYR 490
            ||..:..|:|....: :..|::.|:.|:||..:      .|||.:          :|...| :..
Zfish   536 LDGSFQTEDGRGYER-NEFLRKHNIDTFLICHK------EDDLNEMEAEHPKTRHNNRPWNKEIL 593

  Fly   491 FSFSFSQDYEDIQV-KAQRDMILEVEHMPVNRVQTCKIRRPMHRIAKEDINEEYRFHLESYYLFT 554
            .||| :..|..:.. .|.|.|..|:.    .|::.....|...|:.:|.|..          :..
Zfish   594 ASFS-NGSYTQLPTSSACRSMSKEIN----KRIEHAIDLRSSERMRQEHITP----------VTL 643

  Fly   555 TFRSWRMEWSFNKMRDLLMKYSLGMMVFAGATIIAMDLLVKSEAMD-YTML-FSLFL---LILLP 614
            .|:...:|..|:::||.:.|.:|.........::|:..|:....|. :|:| |.|||   |:||.
Zfish   644 VFKDAHIEEKFSQVRDEMFKTNLVCSFIMLLLLMAVQALIPVPRMYLWTVLQFCLFLLGYLLLLV 708

  Fly   615 LLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFS 679
            ::||...|       .||.....|..  |       |.::..:|..|.|..:.:.:.|:...:..
Zfish   709 MVLAEEFK-------HSPGVLQQFCC--W-------IHENNSMRNLLTITAIAMNFGMALFDMMW 757

  Fly   680 CDIARLELEIINSELHNL----RPQMLCFMPWGVTYAVVIVLSLML------VIIGIPLIIKLGV 734
            |:.:.:: ||...|....    :|...|      ||..|.|||.::      |.:.:..::||.:
Zfish   758 CNSSEMK-EISTRETEGYKAGQKPLTAC------TYPEVFVLSGVVSMVTCAVFLRMSSLLKLTI 815

  Fly   735 GLAILGSHV----ITVHAYYGFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREG-------YL 788
            .|.::..:.    ::.|..|....|....:..........|..::|.|::.|:..|       .|
Zfish   816 LLFVVAVYTYFIEVSFHMLYVHQQEHEHLSRSHFLRRKGVSILLMAMFMIAVLYNGRRWEATTRL 880

  Fly   789 NYI--LKASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVRRRSDQ-LYYENFSQVA 850
            :::  |:|.       ::..|:..::... :.::.||||.|||..|..|.|:|| ||.:::.:|.
Zfish   881 DFLWRLQAQ-------QEVQEMRDLREHN-ECLLHNILPAHVARHFLERNRNDQELYSQSYDEVG 937

  Fly   851 VMFATI-------ENYEADKSG---LRALHEMICYFDELLVNYQSWY-KIEKIKVMGWTYLAACG 904
            ||||:|       |..|....|   |:.|:|:|..|||||  .:|:: .|||||.:|..|:||.|
Zfish   938 VMFASIAGFNDYYEQKEIKHEGVECLKLLNEIIADFDELL--EESYFLDIEKIKTIGSCYMAASG 1000

  Fly   905 LHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEF 969
            |                  ..||..:              ::.|.|....         ||:  |
Zfish  1001 L------------------SPDKQSR--------------VVNDWHHLSE---------LVL--F 1022

  Fly   970 ALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTST 1034
            ||.:...||:|       .|.|.....|::|||||||:|||:|.:||.|||||.|||:||||.||
Zfish  1023 ALAMQETLREI-------NKHSMNNFQLRVGIAHGPVVAGVIGATKPQYDIWGMTVNLASRMDST 1080

  Fly  1035 GVRDGIHVTESTANVLRDFNIRCTYRGMTFVKGV----GQVPTYLVDLDENL 1082
            ||...|.|.|:|.|:|.|:......||..::|||    |:|.||.:.....|
Zfish  1081 GVSGRIQVPEATRNILADWGFVLELRGEIYIKGVSERKGRVRTYFISTKRRL 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	72/155 (46%)
		CYCc	812..1051	CDD:214485	93/250 (37%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	92/249 (37%)
si:dkey-206f10.1	XP_009293230.1	AC_N	<135..380	CDD:292831	51/271 (19%)
		CYCc	343..538	CDD:214485	83/200 (42%)
		Guanylate_cyc	382..564	CDD:278633	78/182 (43%)
		DUF1053	<611..661	CDD:283888	13/63 (21%)
		CYCc	899..1097	CDD:214485	93/250 (37%)
		Guanylate_cyc	928..1126	CDD:278633	92/249 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900