Protein Alignment CG32301 and adcy1a

DIOPT Version :10

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_001161821.1
• Gene: adcy1a / 557026
• ZFINID: ZDB-GENE-070705-302
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1201
• Identity: 309/1201 - (25%)
• Similarity: 509/1201 - (42%)
• Gaps: 301/1201 - (25%)

  Fly    28 YKCRELRLEGVYHRH----------CHLVSVALVTQLIIVIEILML------------IHVILLF 70
            :.|:|  ||.::.::          ..|..:.|....:.::|:|..            :|.::..
Zfish    32 FDCKE--LETLFQKYNLKLEQTATLKALAILILAASALALVELLSAGSRFTVSKGSHPVHCVIFT 94

  Fly    71 S--VVKNIDFLTVLPYFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDLI------ 127
            |  :|.|:.:|.|                   ..::|...:|:|.|...|||.....|.
Zfish    95 SLFIVTNVKYLQV-------------------TQLQQIARLALLFSFTFALLCCPFPLALGHGTQ 140

  Fly   128 ------------------LPICYFRPFSLVPSYDHVVIVLIYLMFPIAFVKNGRAYFLGLAVSLF 174
                              |.:..|..:||:|     |..|:.::|.:..   ..::|:..|.|:
Zfish   141 GTHGPDAPSTTPEQGVWQLMLVTFVAYSLLP-----VRTLLAVLFGVLV---AASHFIVTATSV- 196

  Fly   175 YFGYMALIDKISTLDKVW-ELTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVVYQNLVFQM 238
                      .:...:|| .|.|....|..:|:..:|:....|...|...|.....:.|.|..:.
Zfish   197 ----------TARRPRVWTPLVANAVLLVGVNLSGVFVRVRTERAQRKAFLQARNCIQQRLQLED 251

  Fly   239 AMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSNLMPFTKTRH-LFMEPHPEVSILEADMVDFT 302
            ..::::.||.|::|..:|..:::..          |.|..:..| ::::.|..||||.||:|.||
Zfish   252 ENEKQERLLMSLLPRNVAMEMKEDF----------LKPPERIFHKIYIQRHDNVSILFADIVGFT 306

  Fly   303 GLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDM 367
            .|.:.....:||.:|:|||..||..|..|...|||.|||.|.||:|:......||:.||...|||
Zfish   307 SLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKADHAHCCVEMGLDM 371

  Fly   368 IEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSR 432
            |:....|::.....:::|:|:|:|.:|.|::||.|||:|:||.||.:.|.:|:.||||.|||:..
Zfish   372 IDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLPGKVHITKA 436

  Fly   433 TLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLI-----RSRLPNFEDTDDLEDDNFSLNDYRFS 492
            ||..|:..|..|.|....: ...|.:..:.|:.|     |...|           ...|:|.:
Zfish   437 TLECLNGDYEVEPGFGHER-HAFLSKHAIETFFIVPSHRRKIFP-----------GLILSDIK-- 487

  Fly   493 FSFSQDYEDIQVKAQRDMILEVEH--------MPVNRVQTCK--IRRPMHRIAKEDINEEYRF-- 545
                 ..:.::.|....:::::.|        :|.:.|.||:  .:|...|.|.|.:.....|
Zfish   488 -----PAKRMEFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRTSFSA 547

  Fly   546 ---------HLESY------------------YLFTTFRSWRMEWSFNKMRDLLMKYSLGMMVFA 583
                     .:..|                  |:..|:||...|..:.::.|         ..|.
Zfish   548 GMVQNSPGTRVNRYIGRLIEARQTESEMADLNYITLTYRSREREQRYLQVYD---------DAFI 603

  Fly   584 GATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLL------ASYKKLWLRGRRLSPITQPTFFLSR 642
            .|.:|:: :|....|:.|.::....||:::.|:|      ||...|.:...:.||
Zfish   604 SAVVISL-VLTSFFAVVYFLIIPQGLLVVILLVLCLCFHMASVMYLHVTHVQCSP---------- 657

  Fly   643 WFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSC---------DIARLELEIINSELHNLR 698
                  |.:  ::.:|..|...::.|:|.::...|.:|         .|:.:.:..:|......|
Zfish   658 ------DCL--TLQIRTVLCGFLVLLMYSVTQGCVVTCVPWSLEGNSSISMVTVVTVNGTGVGYR 714

  Fly   699 PQMLC-FMPWGVTYAVVIVLS--LMLVIIGIPLIIKLGVGLAILGSHVITVHAY---YGFAFERS 757
               :| :.|:.....|:..||  |.|.:..:|.|:.| :.|.||.:.|:....|   .|..|..:
Zfish   715 ---VCKYTPYVFLSCVMASLSVALYLRVSSLPKILLL-LLLNILHTVVMETSGYRKAVGGGFFHT 775

  Fly   758 QTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNYILKASY-FMSMCFEKKHELTKVKTRTIKIIMA 821
            .    |....||    |:.|...:|:....|:..|:..| :.:...|::.::.:||... |.|:.
Zfish   776 H----GYDPVLA----MLLFSGALVLHCRQLDLKLRLDYLWATQAEEERDDMERVKLDN-KRILF 831

  Fly   822 NILPTHVAEVFKVRR-RSDQLYYENFSQVAVMFATIENY-----EADKSG-----LRALHEMICY 875
            |:||.|||:.|.:.. |:..|||:::|||.|:||:|.|:     |.|.:.     ||.|:|:|..
Zfish   832 NLLPAHVAQHFLLSNPRNMDLYYQSYSQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIAD 896

  Fly   876 FDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMD 940
            ||.|: :.:.:..|||||.:|.||:||.||           ||    .|..|::||.|..
Zfish   897 FDALM-DKECYRDIEKIKTIGSTYMAAVGL-----------VP----TEGSKVKKSISAH----- 940

  Fly   941 GDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDI--RSKGIFFEKDSKLTGSLKIGIAH 1003
                                  :..:.::|:.:..:|..|  :|...|.         |::||..
Zfish   941 ----------------------LCTVADYAIEMFDVLDAINYQSYNDFV---------LRVGINV 974

  Fly  1004 GPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLR---DFNIRCTYRGMTFV 1065
            |||:|||:|..:|.|||||:|||:||||.||||:..|.|||....:|.   |||  |  ||...|
Zfish   975 GPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVFRLLSGYYDFN--C--RGQVSV 1035

  Fly  1066 KGVGQVPTYLVD---LDENLHFQQHSPDNDS 1093
            ||.||:.||.::   .....|.:..|||.||
Zfish  1036 KGKGQMLTYFLEGRTPQGAQHSRSKSPDQDS 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	116/433 (27%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	68/155 (44%)
		AcyC	681..1076	CDD:441717	132/417 (32%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	90/249 (36%)
adcy1a	NP_001161821.1	AcyC	114..449	CDD:441717	107/363 (29%)
		Guanylate_cyc	287..469	CDD:425528	73/182 (40%)
		Adcy_cons_dom	513..602	CDD:461877	16/97 (16%)
		Guanylate_cyc	852..1048	CDD:425528	90/251 (36%)