Protein Alignment CG32301 and Adcy4

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_062158.2
• Gene: Adcy4 / 54223
• RGDID: 2034
• Length: 1072
• Species: Rattus norvegicus
• Alignment Length: 1127
• Identity: 304/1127 - (26%)
• Similarity: 485/1127 - (43%)
• Gaps: 194/1127 - (17%)

  Fly    54 LIIVIEILMLIHVILLFSV--------VKNIDFLT----VLPYFAVMLLTPSILMPSREPNVEQY 106
            |:|::.:::|..::.|.:|        ..:..|||    .|..|:::|     .:.|||..::::
  Rat    29 LLILLLVIVLCAIVALPAVAWASGRELTSDPSFLTTVLCALGGFSLLL-----GLASREQQLQRW 88

  Fly   107 ESIAILVSCLMALLLTAMDLILPICYFRPFSLVPSYDHV-----VIVLIYLMFPI-------AFV 159
                  ...|..|:..|: |.|...:.....:|.::|.|     :|..:|.|.|:       |.|
  Rat    89 ------TRPLSGLIWAAL-LALGYGFLFTGGVVSAWDQVSFFLFIIFTVYAMLPLGMRDAAAAGV 146

  Fly   160 KNGRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTAYGAYLFFL-NMLCMFLSRFQEYNMRSGI 223
            .:..::.|.|.:   |.|:.    ..|..|.:.:|.| .|.||.. |::..:.....|..:|:..
  Rat   147 ISSLSHLLVLGL---YLGWR----PESQRDLLPQLAA-NAVLFLCGNVVGAYHKALMERALRATF 203

  Fly   224 LSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSNLMPFTKTRH-LFMEP 287
            ......::.........|.::.||.||:|..|||.::..|.:.::...|:....|...| |:::.
  Rat   204 REALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQSSRPENTNNFHSLYVKR 268

  Fly   288 HPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSY 352
            |..||:|.||:|.||.|.:.....:||.:|:|||..||..|..:...|||.|||.|.||:|:|..
  Rat   269 HQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLS 333

  Fly   353 FPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNR 417
            .|.||..||...|||....|::.......|::|:|||||.:|.|:|||.|||:|:||.||.:.|.
  Rat   334 LPDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANH 398

  Fly   418 LESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLEDD 482
            :|:.|:||.|||:..||.||...|..|. .|....||.|:.....|||:.......||....|..
  Rat   399 MEAGGVPGRVHITGATLALLAGAYAVER-ADMEHRDPYLRELGEPTYLVIDPWAEEEDEKGTERG 462

  Fly   483 NFS------------LNDYRFSFSFSQDY---EDIQVKAQRDMIL-EVEHMPVNRVQTCKIRRPM 531
            ..|            :..|..|:..::.:   ..:...|.....| |....|...:...:..|.:
  Rat   463 LLSSLEGHTMRPSLLMTRYLESWGAAKPFAHLSHVDSPASTSTPLPEKAFSPQWSLDRSRTPRGL 527

  Fly   532 H-----RIAK-----EDINEEYR------FHLESYYLFTTFRSWRMEWSFNKMRDLLMKY--SLG 578
            |     ..||     |.:|.:.:      |:|.:.|    ||...||..:........||  :..
  Rat   528 HDELDTGDAKFFQVIEQLNSQKQWKQSKDFNLLTLY----FREKEMEKQYRLSALPAFKYYAACT 588

  Fly   579 MMVFAGATIIAMDLLVKSEAM--DYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLS 641
            .:||.....|.|.:..:..|:  .|::.|.||||:|.........|...:|.:          :.
  Rat   589 FLVFLSNFTIQMLVTTRPPALATTYSITFLLFLLLLFVCFSEHLTKCVQKGPK----------ML 643

  Fly   642 RWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCDIARLELEIINSELHNLRPQM----- 701
            .|....|.|:.....:|:.|....:.|::.|:        :..|....::|:...|.|.:
  Rat   644 HWLPALSVLVATRPGLRVALGTATILLVFTMA--------VVSLLFLPVSSDCPFLAPNVSSVAF 700

  Fly   702 -----------LCFMPWGVTYAVVIVLSLMLVI---IGIPLIIKLGVGLAILGSHVITVHAYYGF 752
                       |..:|:.:...|:..||..|.:   ..:.|::.|   |.::.|..:.:|::...
  Rat   701 NTSWELPASLPLISIPYSMHCCVLGFLSCSLFLHMSFELKLLLLL---LWLVASCSLFLHSHAWL 762

  Fly   753 A-------FERSQTTNIGVTS--SLAHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEKKHEL 808
            :       ::.|..:..||..  .|..:.|...||..::|......|..:..:.......::.|.
  Rat   763 SDCLIARLYQGSLGSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREE 827

  Fly   809 TKVKTRTIKIIMANILPTHVAEVF-KVRRRSDQLYYENFSQVAVMFATIENYEADKSG------- 865
            |:......::::.|:||.|||..| ...||::.||::::..|.|:||:|.:::...|.
  Rat   828 TETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASIPDFKEFYSESNINHEG 892

  Fly   866 ---LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDK 927
               ||.|:|:|..||||| :...:..:||||.:|.||:||.||:.....|
  Rat   893 LECLRLLNEIIADFDELL-SKPKFSGVEKIKTIGSTYMAATGLNATPGQD--------------- 941

  Fly   928 LQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSK 992
                                    ||.......:.:..|.|||:.|       .||.....|.|.
  Rat   942 ------------------------TQQDAERSCSHLGTMVEFAVAL-------GSKLGVINKHSF 975

  Fly   993 LTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDFNIRC 1057
            ....|::|:.||||:|||:|..||.|||||:|||:||||.||||...|.|||.||..|:.....|
  Rat   976 NNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARALQSLGYTC 1040

  Fly  1058 TYRGMTFVKGVGQVPTYLVDLD 1079
            ..||:..|||.||:.||.::.|
  Rat  1041 YSRGVIKVKGKGQLCTYFLNTD 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	72/155 (46%)
		CYCc	812..1051	CDD:214485	84/249 (34%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	86/244 (35%)
Adcy4	NP_062158.2	AC_N	<115..246	CDD:292831	32/138 (23%)
		CYCc	219..422	CDD:214485	85/202 (42%)
		Guanylate_cyc	264..430	CDD:278633	75/166 (45%)
		DUF1053	479..580	CDD:283888	19/104 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..523		4/24 (17%)
		CYCc	824..1039	CDD:214485	87/261 (33%)
		Guanylate_cyc	861..1060	CDD:278633	86/245 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010