DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and Phlpp2

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	112/554 - (20%)
Similarity:	180/554 - (32%)	Gaps:	174/554 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VDYRSLGNMPGYEWKLLRYKCRELRLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVIL------ 68
            :.|..|..:|   .::|  ....||...|.|.|.|::. |||..  |.:|:|.:.|..|
  Rat   568 ISYNLLTEVP---MRIL--SSLSLRKLMVGHNHIHVLP-ALVEH--IPLEVLDVQHNTLSRLPDT 624

  Fly    69 LFSVVKNIDFLTVLPYFAVMLLTPSIL--MPSREPNVEQYESIAILVSCLMALLLT---AMDLIL 128
            |||...|:.:|..         :.:.|  :||.....|.       :|.|..|.||   ..|..:
  Rat   625 LFSKALNLRYLNA---------SANSLESLPSACAGEES-------LSVLQLLYLTNNLLTDQCI 673

  Fly   129 PICYFRPFSLVPSYDHVVIVLI----YLMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLD 189
            |:....|        |:.::.:    ...||.:                          |::.|:
  Rat   674 PVLVGHP--------HLRVLHLANNQLQTFPAS--------------------------KLNKLE 704

  Fly   190 KVWELTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVT 254
            ::.||...|..|..:........|.......:..:|.:..:.|....|........|.:.:||.|
  Rat   705 QLEELNLSGNKLKAIPTTIANCKRLHTLVAHANNISIFPEILQLPQIQFVDLSCNDLTEILIPET 769

  Fly   255 LARSLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHE 319
            |..:|||             :..|...:|         :||...:|.....||:::..
  Rat   770 LPATLQD-------------LDLTGNTNL---------VLEHKTLDMFSHITTLKIDQ------- 805

  Fly   320 LFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDL 384
                             |.|..:.:.||   |.|.:|..|             |::.:|||   |
  Rat   806 -----------------KPLPTTDSTVT---STFWSHGLA-------------EMAGQRNK---L 834

  Fly   385 RIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSG----LPGMVHISSRTLGLLDNHYVYEE 445
            .:...:.:..|..:|.....|| ..::.::...|:.:.    |..:.|.:|.|:.:.:...|...
  Rat   835 CVSALAMDNFAEGVGAVYGMFD-GDRNEELPRLLQCTMADVLLEEVQHSTSDTVFMANTFLVSHR 898

  Fly   446 GTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLEDDNFSLNDYRFS------------------ 492
                 ||....|:...|..|...|    .||.| ...:|||......
  Rat   899 -----KLGMAGQKLGSSALLCYIR----PDTAD-PTSSFSLTVANVGTCQAVLCRGGKPVPLSKV 953

  Fly   493 FSFSQDYEDIQ-VKAQRDMILEVEHMPVNRVQTC 525
            ||...|.|:.| ||.|:.:|  .|...||.|..|
  Rat   954 FSLEHDPEEAQRVKDQKAII--TEDNKVNGVTCC 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	28/159 (18%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761
		PH_PHLPP-like	185..279	CDD:270131
		PLN00113	284..>762	CDD:215061	48/251 (19%)
		leucine-rich repeat	289..309	CDD:275380
		leucine-rich repeat	310..336	CDD:275380
		leucine-rich repeat	337..359	CDD:275380
		leucine-rich repeat	360..382	CDD:275380
		leucine-rich repeat	383..405	CDD:275380
		leucine-rich repeat	406..428	CDD:275380
		leucine-rich repeat	429..452	CDD:275380
		leucine-rich repeat	453..476	CDD:275380
		leucine-rich repeat	477..497	CDD:275380
		leucine-rich repeat	498..517	CDD:275380
		leucine-rich repeat	518..539	CDD:275380
		leucine-rich repeat	540..562	CDD:275380
		leucine-rich repeat	563..584	CDD:275380	4/20 (20%)
		leucine-rich repeat	586..607	CDD:275380	9/23 (39%)
		leucine-rich repeat	608..631	CDD:275380	7/22 (32%)
		leucine-rich repeat	632..681	CDD:275380	13/72 (18%)
		leucine-rich repeat	682..705	CDD:275380	4/48 (8%)
		leucine-rich repeat	706..728	CDD:275380	4/21 (19%)
		leucine-rich repeat	751..772	CDD:275380	6/20 (30%)
		PP2Cc	820..1069	CDD:238083	43/195 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900