DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and NPR1

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_000897.3	Gene:	NPR1 / 4881	HGNCID:	7943	Length:	1061	Species:	Homo sapiens

Alignment Length:	249	Identity:	66/249 - (26%)
Similarity:	120/249 - (48%)	Gaps:	37/249 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 NMLCMFLSRFQEY--NMRSGILSRYQVVYQNLVFQMAMKEEK----ALLDSIIPVTLARSLQDAI 263
            |:|...|||.::|  |:...:..|.|          |..|||    |||..|:|.::|..|:
Human   811 NILDNLLSRMEQYANNLEELVEERTQ----------AYLEEKRKAEALLYQILPHSVAEQLK--- 862

  Fly   264 ASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAA 328
                           :...:..|....|:|..:|:|.||.|:.......:|.:|::|:..||...
Human   863 ---------------RGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVI 912

  Fly   329 NHNRATRIKFLGDSYTCVTGIP-SYFPTHANACVNQALDMIEISR--EVSKRRNKKIDLRIGVHS 390
            ::....:::.:||:|..|:|:| .....||......||.:::..|  .:..|..:::.||||:|:
Human   913 DNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHT 977

  Fly   391 GEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYE 444
            |.:.||::||...::.::...|:..:|:||:|....:|:||.|..:|:....:|
Human   978 GPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFE 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	45/158 (28%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:107380
		ANF_receptor	54..414	CDD:279440
		PK_GC-A_B	534..807	CDD:270944
		TyrKc	547..801	CDD:197581
		HNOBA	<816..861	CDD:285003	17/54 (31%)
		CYCc	840..1032	CDD:214485	56/210 (27%)
		Guanylate_cyc	867..1053	CDD:278633	46/165 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900