DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and CG33958

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster

Alignment Length:	678	Identity:	145/678 - (21%)
Similarity:	237/678 - (34%)	Gaps:	226/678 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 YVYEEGTDTAKLDPLLQRSNLS-------------TYLIRSRLPNFEDTDDLEDDNFSLNDYRFS 492
            |::..|:.        ||:||:             |......:|...|.|: :|....||.|.|.
  Fly   172 YIFTNGSK--------QRANLTLRFANTDHALNNMTTWSEISVPTAPDEDE-DDREMMLNRYEFQ 227

  Fly   493 FSFSQDYEDIQVKAQRDMILEVE--HMPVNRVQTCKIRRPMHRIAKEDINEEYRFHLESYYLFTT 555
            ...::..:.::::.:...|.||.  :..:|       |..:|.:: |.|.|             |
  Fly   228 SRLNEFRDRVRLEPEESSITEVMNWYTSIN-------RGLLHHLS-EQIKE-------------T 271

  Fly   556 FRS--WRMEWSFNKMRDLL----MKYSLGMMVFAGATIIAMDLL--VKSEAMDYTMLFSLFLLIL 612
            ..|  ||....|..:...:    :..|.|:..:...::.|.:.:  |:.|.|...|:.|  .|..
  Fly   272 DNSGVWRYLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAENFVSYVRYEFMAREMINS--TLNY 334

  Fly   613 LPLLLASY-----KKLWLRGRRLSPI---TQPTFFLSRWFIKASDLIEK-SVFVRI-PLAIMVLF 667
            .|:|...|     .|.:.|.:::...   ..|.....|..|:..:|:.. :..:|| ..|:..|.
  Fly   335 APMLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSNERSAIEYYELMNNYTDDLRILQKALRRLI 399

  Fly   668 LLYVMSSETVFSCDIARLELEIINSELHNLRPQMLCFMPWGVTYAVVIVLSLMLVIIGIPLIIKL 732
            ..||  .:|:...|  |.|                         |:.|.: |::|:|..|:||.|
  Fly   400 KEYV--DKTLVEAD--RKE-------------------------AIGIAI-LVVVLIVSPVIIVL 434

  Fly   733 GVGLAILGSHVITVHAYYGFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNYILKASYF 797
                                      ..|...|..|                     |.|..|
  Fly   435 --------------------------VKNAAATIQL---------------------YALNLS-- 450

  Fly   798 MSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVRRRSDQLYYENFSQVAVMFATIENY--- 859
                 :|..||.:.|.::..::. .:||..||...|   ::.|:..|.:..|.:.|:.|..:
  Fly   451 -----QKAKELKREKRKSDSLLF-QMLPPSVAMQLK---QTQQVPAELYEAVTIYFSDIVGFTEI 506

  Fly   860 EADKSGLRA---LHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHV----DHYTDFSVSV 917
            .||.:.|..   |:.:...|||.:    ..|.:.|::.:|.:|:.|.||.|    .|.::.:...
  Fly   507 AADCTPLEVVTFLNSIYRVFDERI----ECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMA 567

  Fly   918 PISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRS 982
                   .|.|..|...|. |..|||.:
  Fly   568 -------LDLLDASSVFRI-PRAGDEFV------------------------------------- 587

  Fly   983 KGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTA 1047
                         .::.|:..|||:||:||...|.|.::|.|||.||||.|||....||:||...
  Fly   588 -------------QIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMH 639

  Fly  1048 NVLRDF-NIRCTYRGMTFVKGVGQVPTY 1074
            :.|:.. ..|..:||:..|||.|.:.||
  Fly   640 DSLQQVGGFRTEHRGLIDVKGKGLMSTY 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850
		CYCc	812..1051	CDD:214485	60/248 (24%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	63/245 (26%)
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	50/255 (20%)
		HNOBA	<439..479	CDD:285003	13/68 (19%)
		CYCc	459..647	CDD:214485	61/253 (24%)
		Guanylate_cyc	485..669	CDD:278633	63/245 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900