DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and GUCY2D

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_000171.1	Gene:	GUCY2D / 3000	HGNCID:	4689	Length:	1103	Species:	Homo sapiens

Alignment Length:	374	Identity:	86/374 - (22%)
Similarity:	164/374 - (43%)	Gaps:	92/374 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PYFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDLILPI--CYFRPFSLVPSYDHV 145
            || |::.|||       |..|::..|...|...|:::....::.||.:  |:.....|.||.||.
Human   745 PY-AMLELTP-------EEVVQRVRSPPPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHT 801

  Fly   146 VIVLIYLMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTAYGAYLFFLNMLCMF 210
                 :.:|  ..:..||                    |.:.:|.:            |.||..:
Human   802 -----FDLF--KNINKGR--------------------KTNIIDSM------------LRMLEQY 827

  Fly   211 LSRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKA--LLDSIIPVTLARSLQDAIASHIEEDPSN 273
            .|     |:...|..|.:        ::.::::|.  ||..::|.::|.:|:....
Human   828 SS-----NLEDLIRERTE--------ELELEKQKTDRLLTQMLPPSVAEALKTGTP--------- 870

  Fly   274 LMPFTKTRHLFMEPH--PEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRI 336
                       :||.  .:|::..:|:|.||.::...|..::|.:|::|:..||.....:...::
Human   871 -----------VEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKV 924

  Fly   337 KFLGDSYTCVTGIPS-YFPTHANACVNQALDMIEISREVSKRRNKKID--LRIGVHSGEILAGII 398
            :.:||:|...:|:|. ....||....|.:||::........|...::.  :|||:|||..:||::
Human   925 ETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVV 989

  Fly   399 GLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGL---LDNHYVYE 444
            |||..::.::...|:..:|:||:|||..:|::..|:|:   ||:.|..|
Human   990 GLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVE 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	46/163 (28%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594
		PK_GC-2D	536..811	CDD:270945	20/80 (25%)
		HNOBA	<820..865	CDD:369471	12/69 (17%)
		CYCc	846..1036	CDD:214485	53/209 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1103
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900