Protein Alignment CG32301 and GUCY2F

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_001513.2
• Gene: GUCY2F / 2986
• HGNCID: 4691
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 1096
• Identity: 228/1096 - (20%)
• Similarity: 374/1096 - (34%)
• Gaps: 317/1096 - (28%)

  Fly   103 VEQYESIAILVSCL----------MALLLTAMDLILPICYFRPFSLVPSYDHVVIVLIYLMFPIA 157
            :.|.:.|.|::.|:          |.||..|.||.:.   ...:..|| ||.::..|.|...|..
Human   236 IHQADRIRIIIMCMHSALIGGETQMHLLECAHDLKMT---DGTYVFVP-YDALLYSLPYKHTPYR 296

  Fly   158 FVKNGRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTAYGAYLFFLNMLCMFLSRFQEYNMRSG 222
            .::|.                          .|:.|  ||.|.|...
Human   297 VLRNN--------------------------PKLRE--AYDAVLTIT------------------ 315

  Fly   223 ILSRYQVVYQNLVFQMAMKE--EKALLDSIIPV---------TLARSLQDAIASHIEEDPSNLMP 276
            :.|:.:..||......|..|  ||...|.:.|:         .:|:::.:|:..:.:...::|:.
Human   316 VESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQ 380

  Fly   277 FTKTRHLFMEPHPEVSILEAD-----MVDFTGLTTTMEVSDLVAILHELF-VSFDLAANHNRATR 335
            .::.    |:.|....::..|     :.::..|.|.::..:    ||..: |..::.......|.
Human   381 HSRN----MQFHGFNQLMRTDSNGNGISEYVILDTNLKEWE----LHSTYTVDMEMELLRFGGTP 437

  Fly   336 IKFLG-------------DSYTCVTGIPSYFPTHANACVNQALDMIEIS--REVSKRRNKKIDLR 385
            |.|.|             :...|..||...|.  ...|:...:.::.|:  ....:||..||.|.
Human   438 IHFPGGRPPRADAKCWFAEGKICHGGIDPAFA--MMVCLTLLIALLSINGFAYFIRRRINKIQLI 500

  Fly   386 IGVHSGEILAGIIGLTKWQFDIWSK-------DVDITNRLESSGLPGMVHISSRTLGLLDNHYVY 443
            .|  ...||..:..:|.......||       ...||:.::|...| .:..||.:|    ....|
Human   501 KG--PNRILLTLEDVTFINPHFGSKRGSRASVSFQITSEVQSGRSP-RLSFSSGSL----TPATY 558

  Fly   444 EEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLEDD-----NFSLNDYRFSFSFSQDYEDIQ 503
            |             .||::.|               |.|     .|||.|:       .|.:.|:
Human   559 E-------------NSNIAIY---------------EGDWVWLKKFSLGDF-------GDLKSIK 588

  Fly   504 VKAQR--DMILEVEHMPVNRVQTCKIRRPMHRIAKEDINEEYRFHLESYYLFTTFRSWRMEWSFN 566
            .:|..  :|:.::.|..:|.:........|..|..|..:   |..||.   ..|.:..:::|.|.
Human   589 SRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEFCS---RGSLED---ILTNQDVKLDWMFK 647

  Fly   567 K--MRDLL--MKYSLGMMVFAGATIIAMDLLVKS----EAMDYTMLFSLFLLILLPLLLASYKKL 623
            .  :.||:  ||| |....|....:.:.:.:|..    :..||.....|.:|.|.....:..:.|
Human   648 SSLLLDLIKGMKY-LHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELL 711

  Fly   624 WL--------RGRRLSPITQPTFFLSRWFIKASDLIEKSVFVR-IPLAIMVLFLLYVMSSETVFS 679
            |.        ||.||.......:..:        :|.:.|.|| .|..:|.|
Human   712 WTAPELLRAPRGSRLGSFAGDVYSFA--------IIMQEVMVRGTPFCMMDL------------- 755

  Fly   680 CDIARLELEIINSELHNLRPQMLCFMPWGVTYAVVIVLSLMLVIIGIPLIIKLGVGLAILGSHVI 744
                 ...|||| .|....|.....:|  ..:|....|.||                ....:...
Human   756 -----PAQEIIN-RLKKPPPVYRPVVP--PEHAPPECLQLM----------------KQCWAEAA 796

  Fly   745 TVHAYYGFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEKKHELT 809
            .....:...|.:.:|.|.|..:::..|        ::.:.|.|      :|....:..|:..||.
Human   797 EQRPTFDEIFNQFKTFNKGKKTNIIDS--------MLRMLEQY------SSNLEDLIRERTEELE 847

  Fly   810 KVKTRTIKIIMANILPTHVAEVFK----VRRRSDQLYYENFSQVAVMFATIENYEADKSGLRALH 870
            ..|.:|.| ::..:||..|||..|    |......|....||.: |.|.||.........:..|:
Human   848 IEKQKTEK-LLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDI-VGFTTISAMSEPIEVVDLLN 910

  Fly   871 EMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVR 935
            ::...||.::.::.. ||:|.|   |..|:.|.||...:.:..:..:   .|...|.|...|:.:
Human   911 DLYTLFDAIIGSHDV-YKVETI---GDAYMVASGLPKRNGSRHAAEI---ANMSLDILSSVGTFK 968

  Fly   936 FAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIG 1000
            ...|  .|:.::                                                 ::||
Human   969 MRHM--PEVPVR-------------------------------------------------IRIG 982

  Fly  1001 IAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDFN--IRCTYRGMT 1063
            :..|||:||||||:.|.|.::|.|||.||||.|||:...|||:.||..:|::.:  .....||.|
Human   983 LHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRT 1047

  Fly  1064 FVKGVGQVPTYLVDLDENLHFQQHSP-----DNDSHKG---SIVSVHWLDEKRAER 1111
            .:||.|...|:.  |.....|.:..|     |.|...|   ..|.:.....::|||
Human  1048 ELKGKGTEETFW--LIGKKGFMKPLPVPPPVDKDGQVGHGLQPVEIAAFQRRKAER 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	36/183 (20%)
		CYCc	812..1051	CDD:214485	64/242 (26%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	62/236 (26%)
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF_like	54..435	CDD:107366	44/256 (17%)
		ANF_receptor	75..412	CDD:279440	40/229 (17%)
		PKc_like	545..815	CDD:304357	69/360 (19%)
		HNOBA	<824..869	CDD:285003	14/51 (27%)
		CYCc	848..1040	CDD:214485	65/251 (26%)
		Guanylate_cyc	875..1062	CDD:278633	64/247 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900