DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and GUCY2C

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	282	Identity:	77/282 - (27%)
Similarity:	133/282 - (47%)	Gaps:	56/282 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 TLARSLQ--DAIASHIEEDPSN---------------LMPFTKTRHL----FMEP--HPEVSILE 295
            ||.|.||  .....|:.|:.:.               |:|....:.|    |:||  :.||:|..
Human   763 TLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYF 827

  Fly   296 ADMVDFTGL---TTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPT-H 356
            :|:|.||.:   :|.|||.|:   |::::.|||...:|:...:::.:||:|...:|:|..... |
Human   828 SDIVGFTTICKYSTPMEVVDM---LNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRH 889

  Fly   357 ANACVNQALDMIEI--SREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLE 419
            |......||:::..  :.|:.......|.:|||||||...||::|:...::.::...|:..:|:|
Human   890 AIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954

  Fly   420 SSGLPGMVHISSRTLGLL---DNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLED 481
            |:|||..:|:|..|:.:|   :..::||...:|.    |..|.|.:||.:..          ::|
Human   955 STGLPLRIHVSGSTIAILKRTECQFLYEVRGETY----LKGRGNETTYWLTG----------MKD 1005

  Fly   482 DNFSL-------NDYRFSFSFS 496
            ..|:|       |..|....||
Human  1006 QKFNLPTPPTVENQQRLQAEFS 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	53/170 (31%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364
		PK_GC-C	480..750	CDD:270946
		Pkinase_Tyr	502..745	CDD:285015
		CYCc	788..979	CDD:214485	55/193 (28%)
		Guanylate_cyc	815..1002	CDD:278633	59/193 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900