DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and GUCY1B1

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	XP_011530203.1	Gene:	GUCY1B1 / 2983	HGNCID:	4687	Length:	662	Species:	Homo sapiens

Alignment Length:	383	Identity:	80/383 - (20%)
Similarity:	160/383 - (41%)	Gaps:	89/383 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 GRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTAYGAYLFFLNM------LCMFLSRF-QEYNM 219
            |:..:|..|.|:.:.    ....:..||   :||..|.||..:.:      |.:...:| :||.:
Human   308 GQMIYLPEADSILFL----CSPSVMNLD---DLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKL 365

  Fly   220 RSGILSRYQVVYQNLVFQM-AMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSN---------- 273
            ...:    :::...|...: |:::||...|:..|..:............|:|..:
Human   366 TQEL----EILTDRLQLTLRALEDEKKKTDTGCPARIQAFKVQTTLMLCEKDSRSTKGFPSISYS 426

  Fly   274 ---LMPFTKTRHLFMEP----------------HPEVSILEADMVDFTGLTTTMEVSD----LVA 315
               |:|..:..:..:.|                :..|:||.:.:|.|....:.....:    :|.
Human   427 GFLLIPLNRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVN 491

  Fly   316 ILHELFVSFDLAANHNR---ATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKR 377
            :|::|:..||...:..:   ..:::.:||.|..|:|:|.....||.:..:.||||:||:.:| :.
Human   492 LLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QV 555

  Fly   378 RNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYV 442
            ..:.:.:.||:|:||::.|:||....::.::...|::|:|.|::|..|.:::|..|...|    :
Human   556 DGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL----M 616

  Fly   443 YEEGTD-------------TAKLDPL----LQRSNLSTYLIRSRLPNFEDTDDLEDDN 483
            ..|.:|             ..|.:|:    |.|.|..|          |:|.  :||:
Human   617 SPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGT----------EETK--QDDD 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	43/178 (24%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:311572
		HNOBA	207..449	CDD:311573	26/151 (17%)
		Guanylate_cyc	455..648	CDD:306677	46/197 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900