DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and GUCY1A1

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens

Alignment Length:	539	Identity:	108/539 - (20%)
Similarity:	193/539 - (35%)	Gaps:	183/539 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KNIDFLTVLPYFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDL-ILPICYF---- 133
            |..|||.|  |:.....|.|:::|            .|:.:....|..|.::: ::|.|:.
Human   195 KEDDFLHV--YYFFPKRTTSLILP------------GIIKAAAHVLYETEVEVSLMPPCFHNDCS 245

  Fly   134 ----RPF------------SLVPSYDHVVIV----LIYLMFPIAFV------------------- 159
                :|:            ||.||.....:|    |....||..|:
Human   246 EFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMN 310

  Fly   160 -------KNGRAYF--LGLAVSLFYFGYMALI------------DKISTLDKVWELTAYGAY--- 200
                   .|...||  |...::..:.|.|.::            :.:....:|.:|.....|
Human   311 RRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVE 375

  Fly   201 ---LFFLNMLC-----------MFLSRFQEYN-MRSGILSRYQVVYQNLV-------------FQ 237
               :.||...|           ::||....:| :|..:|...|...|:.:             ..
Human   376 SSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAH 440

  Fly   238 MAMKEEKA----LLDSIIPVTLARSL-QDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEAD 297
            .|::|||.    ||.||.|..:|:.| |..:..                   .:....|::|.:|
Human   441 QALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQ-------------------AKKFSNVTMLFSD 486

  Fly   298 MVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVN 362
            :|.||.:.:......::.:|:.|:..||.........:::.:||:|....|:.....|||.....
Human   487 IVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIAL 551

  Fly   363 QALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMV 427
            .||.|:|:|.||.....:.|.:|||:|||.:.||::|:...::.::..:|.:.|:.||..:|..:
Human   552 MALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKI 616

  Fly   428 HISSRTLGLLDN--------------------------HYV--YEEGTDTAKLDPLLQRSNLSTY 464
            ::|..|..||.:                          |::  |::||::   .|..|:.
Human   617 NVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNS---KPCFQKK----- 673

  Fly   465 LIRSRLPNFEDTDDLEDDN 483
                         |:||.|
Human   674 -------------DVEDGN 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	43/155 (28%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	33/188 (18%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	43/189 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900