DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and GUCY1A2

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens

Alignment Length:	286	Identity:	67/286 - (23%)
Similarity:	114/286 - (39%)	Gaps:	90/286 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 AMKEEKA----LLDSIIPVTLARSL---QDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEA 296
            |::|||.    ||.||.|..:|:.|   |...|...:                     :|::|.:
Human   482 ALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFD---------------------DVTMLFS 525

  Fly   297 DMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACV 361
            |:|.||.:........::::|:||:..||.........:::.:||:|....|:......||....
Human   526 DIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIA 590

  Fly   362 NQALDMIEISREVSKRRNKKID-------------------------------LRIGVHSGEILA 395
            ..||.|:|:|.||.....:.|.                               :|||:|||.:||
Human   591 LMALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEKMRIGIHSGSVLA 655

  Fly   396 GIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSN 460
            |::|:...::.::..:|.:.::.||...|..:::|..|         |:          ||:|..
Human   656 GVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT---------YQ----------LLKREE 701

  Fly   461 LSTYLIRSR--LPNFEDTDDLEDDNF 484
            ..|::.|||  ||          |||
Human   702 SFTFIPRSREELP----------DNF 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	41/186 (22%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002
		HNOBA	316..503	CDD:285003	9/20 (45%)
		CYCc	485..705	CDD:214485	57/259 (22%)
		Guanylate_cyc	514..729	CDD:278633	55/254 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900