DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and Gucy2c

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_037302.1	Gene:	Gucy2c / 25711	RGDID:	2771	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	89/321 - (27%)
Similarity:	146/321 - (45%)	Gaps:	71/321 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 TLARSLQ--DAIASHIEEDPSNLMPFTKTR--HL-FM----------------EP--HPEVSILE 295
            ||.|.||  .....|:.|:.:.|....:.|  || ||                ||  :.||:|..
  Rat   762 TLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYF 826

  Fly   296 ADMVDFTGL---TTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPT-H 356
            :|:|.||.:   :|.|||.|:   |::::.|||...:|:...:::.:||:|...:|:|..... |
  Rat   827 SDIVGFTTICKYSTPMEVVDM---LNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRH 888

  Fly   357 ANACVNQALDMIEI--SREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLE 419
            |......|||::..  :.|:.......:.:|||||||...||::|:...::.::...|:..:|:|
  Rat   889 AVDISKMALDILSFMGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 953

  Fly   420 SSGLPGMVHISSRTLGLL---DNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLED 481
            |:|||..:|:||.|:.:|   |..::||...:|.    |..|...:||.:..          ::|
  Rat   954 STGLPLRIHMSSSTIAILRRTDCQFLYEVRGETY----LKGRGTETTYWLTG----------MKD 1004

  Fly   482 DNFSL-------NDYRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCKIRRPMHRIA 535
            ..::|       |..|....||            |||  |..:...:....|.|||. |:|
  Rat  1005 QEYNLPTPPTVENQQRLQTEFS------------DMI--VSALQKRQASGVKSRRPT-RVA 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	55/183 (30%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141
		PKc_like	479..749	CDD:304357
		STYKc	501..744	CDD:214568
		CYCc	787..978	CDD:214485	58/193 (30%)
		Guanylate_cyc	814..1001	CDD:278633	60/193 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900