Protein Alignment CG32301 and Adcy6

DIOPT Version :10

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_001257714.1
• Gene: Adcy6 / 25289
• RGDID: 2035
• Length: 1180
• Species: Rattus norvegicus
• Alignment Length: 1195
• Identity: 300/1195 - (25%)
• Similarity: 509/1195 - (42%)
• Gaps: 311/1195 - (26%)

  Fly    31 RELRLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDFLTVLPYFAVMLLTPSIL 95
            |..:||.:|.|:...::.:.:|.|:.|:.:||.  |:|.|..                  .|::.
  Rat   144 RSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMA--VLLTFHA------------------APALP 188

  Fly    96 MPSREPNVEQYESIAILVSCLMALLLTAMDLILPIC---YFRPFSL-VPSYDHVVI-VLIYLMFP 155
            .|          :...|::|...|.:    :::.:|   .||..|: |.||  ||: :|..:...
  Rat   189 QP----------AYVALLTCASVLFV----VLMVVCNRHSFRQDSMWVVSY--VVLGILAAVQVG 237

  Fly   156 IAFVKNGRAYFLGLAVSLF--YFGYMALIDK----------ISTLDKV--WELTAYGAYLF---F 203
            .|...|.|:...||...:|  |..|..|..:          :|||..:  |.|.....:|:   .
  Rat   238 GALAANPRSPSAGLWCPVFFVYITYTLLPIRMRAAVLSGLGLSTLHLILAWHLNNGDPFLWKQLG 302

  Fly   204 LNMLCMFL------------------SRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSI 250
            .|:: :||                  ..|||  .|..|.:|..:.::|       ::::.||.|:
  Rat   303 ANVV-LFLCTNAIGVCTHYPAEVSQRQAFQE--TRGYIQARLHLQHEN-------RQQERLLLSV 357

  Fly   251 IPVTLARSLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVA 315
            :|..:|..:::.|.:..|:     |.|.|   ::::.|..||||.||:..||.|.:.....:||.
  Rat   358 LPQHVAMEMKEDINTKKED-----MMFHK---IYIQKHDNVSILFADIEGFTSLASQCTAQELVM 414

  Fly   316 ILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNK 380
            .|:|||..||..|..|...|||.|||.|.||:|:|.....||:.||...:||||....|.:....
  Rat   415 TLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGV 479

  Fly   381 KIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEE 445
            .:::|:|:|||.:..|::||.|||||:||.||.:.|.:|:.|..|.:||:..||..|:..|..|.
  Rat   480 NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEP 544

  Fly   446 GTDTAKLDPLLQRSNLSTYLI------------------RSRLPNFEDTDD--LEDDNFSLNDYR 490
            |.. .:.:..|:...:.|:||                  |:|..:.|....  :.|..||..  :
  Rat   545 GRG-GERNAYLKEQCIETFLILGASQKRKEEKAMLVKLQRTRANSMEGLMPRWVPDRAFSRT--K 606

  Fly   491 FSFSFSQDYEDIQVKAQR---------DMILE-----VEHMPVNRVQTCKIRRPMHRIAKEDINE 541
            .|.:|.|...|...|..|         |.:.|     ::...:::::...:||.:....:||:.:
  Rat   607 DSKAFRQMGIDDSSKENRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEK 671

  Fly   542 EYRFHLESYYLFTTFRSWRMEWSFNKMRDLLMKYSLGMMVFAGATIIAMDLLVKSEAMDYTMLFS 606
            :|              |.:::..|...      .:..::||.....|.. |:....|:...:...
  Rat   672 KY--------------SRKVDPRFGAY------VACALLVFCFICFIQF-LVFPHSALILGIYAG 715

  Fly   607 LFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYV 671
            :|||:|:.:|:.:             :.....|......:.|..|.:|......:.:..:.|:::
  Rat   716 IFLLLLVTVLICA-------------VCSCGSFFPNALQRLSRSIVRSRVHSTAVGVFSVLLVFI 767

  Fly   672 MSSETVFSC------------------DIARLELEIINSELHNLRPQMLC--------FMPWGVT 710
            .:...:|:|                  |:....|..:|..|....|  ||        |..:.|.
  Rat   768 SAIANMFTCSHTPLRTCAARMLNLTPSDVTACHLRQLNYSLGLEAP--LCEGTAPTCSFPEYFVG 830

  Fly   711 YAVVIVLS-------------LMLVIIGI--PLIIKLGVGLAILGSH--VITVHAYYGFA----- 753
            ..::.:|:             :|..::|.  .|::.||....|..::  :::||   |.|
  Rat   831 SVLLSLLASSVFLHISSIGKLVMTFVLGFIYLLLLLLGPPATIFDNYDLLLSVH---GLASSNET 892

  Fly   754 FERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLN-------------YILKASYFMSMCFEKK 805
            |:......:|..:..    ||....::|.....||:             :.|:|:       .:|
  Rat   893 FDGLDCPAVGRVALK----YMTPVILLVFALALYLHAQQVESTARLDFLWKLQAT-------GEK 946

  Fly   806 HELTKVKTRTIKIIMANILPTHVAEVFKVR-RRSDQLYYENFSQVAVMFATIENY-------EAD 862
            .|:.:::... :.::.||||..||..|..| ||:|:|||::...||||||:|.|:       ||:
  Rat   947 EEMEELQAYN-RRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEAN 1010

  Fly   863 KSG---LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRE 924
            ..|   ||.|:|:|..||| :::.:.:.::||||.:|.||:||.||:...|
  Rat  1011 NEGVECLRLLNEIIADFDE-IISEERFRQLEKIKTIGSTYMAASGLNASTY-------------- 1060

  Fly   925 SDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEK 989
             |::.:|                  |            |..:.::|:.|:..::.|       .:
  Rat  1061 -DQVGRS------------------H------------ITALADYAMRLMEQMKHI-------NE 1087

  Fly   990 DSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVL--RD 1052
            .|.....:|||:..|||:|||:|..||.|||||:|||::|||.||||.|.|.||.....||  :.
  Rat  1088 HSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG 1152

  Fly  1053 FNIRCTYRGMTFVKGVGQVPTYLVD 1077
            :.:.|  ||:..|||.|::.||.::
  Rat  1153 YQLEC--RGVVKVKGKGEMTTYFLN 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	125/433 (29%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	66/155 (43%)
		AcyC	681..1076	CDD:441717	126/450 (28%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	84/246 (34%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:318454	61/286 (21%)
		Guanylate_cyc	382..566	CDD:425528	73/184 (40%)
		Adcy_cons_dom	594..681	CDD:461877	17/102 (17%)
		Guanylate_cyc	982..1176	CDD:425528	84/249 (34%)