DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_036901.2	Gene:	Gucy1b1 / 25202	RGDID:	2769	Length:	619	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	82/360 - (22%)
Similarity:	160/360 - (44%)	Gaps:	86/360 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 GRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTAYGAYLFFLNM------LCMFLSRF-QEYNM 219
            |:..:|..|.|:.:.    ....:..||   :||..|.||..:.:      |.:...:| :||.:
  Rat   308 GQMIYLPEADSILFL----CSPSVMNLD---DLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKL 365

  Fly   220 RSG---ILSRYQVVYQNLVFQMAMKEEK----ALLDSIIPVTLARSLQDAIASHIEEDPSNLMPF 277
            ...   :..|.|:..:      |:::||    .||.|::|.::|..|:     |....|:
  Rat   366 TQELEILTDRLQLTLR------ALEDEKKKTDTLLYSVLPPSVANELR-----HKRPVPA----- 414

  Fly   278 TKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSD----LVAILHELFVSFDLAANHNR---ATR 335
                    :.:..|:||.:.:|.|....:.....:    :|.:|::|:..||...:..:   ..:
  Rat   415 --------KRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYK 471

  Fly   336 IKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGL 400
            ::.:||.|..|:|:|.....||.:..:.||||:||:.:| :...:.:.:.||:|:||::.|:||.
  Rat   472 VETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQ 535

  Fly   401 TKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTD-------------TAKL 452
            ...::.::...|::|:|.|::|..|.:::|..|...|    :..|.:|             ..|.
  Rat   536 RMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL----MSPENSDPQFHLEHRGPVSMKGKK 596

  Fly   453 DPL----LQRSNLSTYLIRSRLPNFEDTDDLEDDN 483
            :|:    |.|.|..|          |:|:  :|:|
  Rat   597 EPMQVWFLSRKNTGT----------EETN--QDEN 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	42/162 (26%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
Gucy1b1	NP_036901.2	HNOB	2..166	CDD:285002
		HNOBA	207..406	CDD:285003	25/110 (23%)
		CYCc	385..584	CDD:214485	54/221 (24%)
		Guanylate_cyc	412..605	CDD:278633	47/210 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900