Protein Alignment CG32301 and Gucy2g

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_620611.2
• Gene: Gucy2g / 245708
• RGDID: 621853
• Length: 1103
• Species: Rattus norvegicus
• Alignment Length: 1010
• Identity: 206/1010 - (20%)
• Similarity: 337/1010 - (33%)
• Gaps: 345/1010 - (34%)

  Fly   183 DKISTLDKVWELTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVVYQNL---VFQMAMKEEK 244
            ||::...||:|              .:||.....|...:|.....:.|||.|   .||.::..|
  Rat   295 DKVTRFPKVYE--------------SVFLIAPSTYGGSAGDDDFRKQVYQRLRRPPFQSSISSE- 344

  Fly   245 ALLDSIIPVTLARSLQDAI---ASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTT 306
               |.:.|  .:..|.||:   |..:||       ..|....|.:....:|.|.||.|...|:|.
  Rat   345 ---DQVSP--YSAYLHDALLLYAQTVEE-------MMKAEKDFRDGRQLISTLRADQVTLQGITG 397

  Fly   307 TMEVSDLVAILHELFVSFDLAANHNRATRIKFLG-DSYTCVT--------------GIPSYFPT- 355
            .: :.|.....|..:..:.|..:.|.:..:.||. ||:..|.              ..|.|.|.
  Rat   398 PV-LLDAQGKRHMDYSVYALQKSGNGSRFLPFLHYDSFQKVIRPWRDDLNASGPHGSHPEYKPDC 461

  Fly   356 --HANAC-------------VNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQF 405
              |.:.|             |...:..:.:....|                  .|.|.||..|:.
  Rat   462 GFHEDLCRTKPPTGAGMTASVTAVIPTVTLLVVAS------------------AAAITGLMLWRL 508

  Fly   406 DIWSKDVDITNRLESSGLPG----MVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLI 466
                       |.:....||    .:|..|.|  ||..|.....||..::.:.    ||.||..|
  Rat   509 -----------RGKVQNHPGDTWWQIHYDSIT--LLPQHKPSHRGTPMSRCNV----SNASTVKI 556

  Fly   467 RSRLPNFEDTDDLEDDNFS-LNDYRFS-FSFSQDYEDIQVKAQRDMIL-------EVEH---MPV 519
            .:...:|..|...|:..:: :..|:.: .:.....|:.:.:.::..:|       |::|   :|.
  Rat   557 SADCGSFAKTHQDEELFYAPVGLYQGNHVALCYIGEEAEARIKKPTVLREVWLMCELKHENIVPF 621

  Fly   520 NRVQT-----CKIRRPMHRIAKEDI--NEEYRFHLESYYLFTTFRSWRMEWSFNKMRDLLMKYSL 577
            ..|.|     |.:.:...:.:.:|:  |.::                .|:|.|.    |...|.:
  Rat   622 FGVCTEPPNICIVTQCCKKGSLKDVLRNSDH----------------EMDWIFK----LSFVYDI 666

  Fly   578 --GMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFL 640
              ||:...|:.:.:...|..|..                 |:.|:.:|.|.|..|
  Rat   667 VNGMLFLHGSPLRSHGNLKPSNC-----------------LVDSHMQLKLAGFGL---------- 704

  Fly   641 SRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCDIARLELEIINSELHNLRPQMLCF- 704
              |..|...                             :|.|...| ...:|||:...|::|..
  Rat   705 --WEFKHGS-----------------------------TCRIYNQE-ATDHSELYWTAPELLRLR 737

  Fly   705 -MPW-----GVTYAVVIVLSLML----------------VIIG--------IPLIIKLGVGLAIL 739
             :||     |..|:..|:|..::                .||.        :||...|   |...
  Rat   738 ELPWSGTPQGDVYSFAILLRDLIHQQAHGPFEDLEAAPEEIISCIKDSRAPVPLRPSL---LEDK 799

  Fly   740 GSH--VITVHAYYGF------AF--------ERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYL 788
            |..  |..|.|.:..      ||        |.|....:.:..|:.....|.|..:..||.|...
  Rat   800 GDERIVALVRACWAESPEQRPAFPSIKKTLREASPRGRVSILDSMMGKLEMYASHLEEVVEERTC 864

  Fly   789 NYILKASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVRRRSDQLYYENFSQVAVMF 853
            ..:                   .:.|.::.:::.:||:.|.|.....:..:.   |:|..|.:.|
  Rat   865 QLV-------------------AEKRKVEKLLSTMLPSFVGEQLIAGKSVEP---EHFESVTIFF 907

  Fly   854 ATIENY------EADKSGLRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTD 912
            :.|..:      .:....::.|:::...||..:..:.. ||:|.|   |..|:.|.||
  Rat   908 SDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQTHDV-YKVETI---GDAYMVASGL------- 961

  Fly   913 FSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRIL 977
                                .:|......|||....||....|||           |.:..:
  Rat   962 --------------------PIRNGAQHADEIATMSLHLLSVTTN-----------FQIGHM--- 992

  Fly   978 RDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHV 1042
                       .:.:|  .|:||:..|||:|||||::.|.|.::|.||||||||.|:.:...|||
  Rat   993 -----------PEERL--KLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHV 1044

  Fly  1043 TESTANVL---RDFNIRCTYRGMTFVKGVGQVPTY 1074
            ::|||..|   ..::::  .||...|||.|:..|:
  Rat  1045 SQSTARALLVAGGYHLQ--KRGTISVKGKGEQTTF 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	37/190 (19%)
		CYCc	812..1051	CDD:214485	63/247 (26%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	65/243 (27%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	42/171 (25%)
		ANF_receptor	66..417	CDD:279440	35/149 (23%)
		PK_GC	558..832	CDD:270894	58/355 (16%)
		CYCc	868..1058	CDD:214485	63/250 (25%)
		Guanylate_cyc	895..1081	CDD:278633	65/246 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900