DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_001028494.1	Gene:	Gucy1a2 / 234889	MGIID:	2660877	Length:	730	Species:	Mus musculus

Alignment Length:	255	Identity:	68/255 - (26%)
Similarity:	116/255 - (45%)	Gaps:	59/255 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 AMKEEKA----LLDSIIPVTLARSL---QDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEA 296
            |::|||.    ||.||.|..:|:.|   |...|...:                     :|::|.:
Mouse   480 ALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFD---------------------DVTMLFS 523

  Fly   297 DMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACV 361
            |:|.||.:........::::|:||:..||.........:::.:||:|...:|:......||....
Mouse   524 DIVGFTAICAQCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCVASGLHRKSLCHAKPIA 588

  Fly   362 NQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGM 426
            ..||.|:|:|.||.....|.|.:|||:|||.:|||::|:...::.::..:|.:.::.||...|..
Mouse   589 LMALKMMELSEEVLTPDGKAIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRR 653

  Fly   427 VHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSR--LPNFEDTDDLEDDNF 484
            :::|..|         |:          ||:|.:..|::.|||  ||          |||
Mouse   654 INVSPTT---------YQ----------LLKREDSFTFIPRSREELP----------DNF 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	42/155 (27%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
Gucy1a2	NP_001028494.1	HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	9/20 (45%)
		CYCc	483..672	CDD:214485	58/228 (25%)
		Guanylate_cyc	512..696	CDD:278633	56/223 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900