DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and PHLPP1

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	654	Identity:	127/654 - (19%)
Similarity:	231/654 - (35%)	Gaps:	217/654 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 NLSTYLIRSRLPNFEDTDDLEDDNFSLNDYRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQT 524
            ||.|:|:..   ||..:...|.:|.....| ...||: ::.||....::...::...|..|.|:|
Human   738 NLQTFLLDG---NFLQSLPAELENMKQLSY-LGLSFN-EFTDIPEVLEKLTAVDKLCMSGNCVET 797

  Fly   525 CKIR--RPMHRIAKED---------INEEYRF--HLESYYLFTTFRSWRMEWSFNKMRDLLMKYS 576
            .:::  |.|..|...|         |.:|..|  |:.           :::...||:.|
Human   798 LRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVT-----------QLDLRDNKLGD------ 845

  Fly   577 LGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLS 641
            |..|:|....::..:   :::              |:.|.:..|                  ||.
Human   846 LDAMIFNNIEVLHCE---RNQ--------------LVTLDICGY------------------FLK 875

  Fly   642 RWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSS----ETV--FSCDIARLE-LEIINSELHNLRP 699
            ..:..:::|::..|: .:|     .:|.|:..|    |.|  :.|:..:|| |:|.::::..|..
Human   876 ALYASSNELVQLDVY-PVP-----NYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPA 934

  Fly   700 QMLC---------------FMPWGVTYAVVIVLSL---MLVIIGIPLIIKLGVGLAILGSHVITV 746
            ::.|               .:|..:....|.||.:   .|:.:...|::|.. .|..|.:....:
Human   935 RLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKAD-SLRFLNASANKL 998

  Fly   747 HAYYGFAFERSQTTNIGVTSSLAHSWYMVAFFIV---VVVREGYLNY-ILKASY-----FMSMCF 802
            .:.       ...|....|:|:....|:....:.   |.:..|:.:. ||..:|     |.:...
Human   999 ESL-------PPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKM 1056

  Fly   803 EKKHELTKV-----KTRTIKIIMANILPTHVA-------EVFKVRRRSDQLYYENFSQVAVMFAT 855
            .|..||.::     |.:.|...:.|....|..       |||....:..::...:.|...:...|
Human  1057 AKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVT 1121

  Fly   856 I-EN-----YEADKSGLRAL---HEMICYFDELLVNYQSWYKIEK-----------IKVMGWT-- 898
            : ||     .|.|.:|...|   |:.:    |||.|.:. :||::           :...|:|
Human  1122 LPENLPPKLQELDLTGNPRLVLDHKTL----ELLNNIRC-FKIDQPSTGDASGAPAVWSHGYTEA 1181

  Fly   899 -----YLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGD--------------EI 944
                 .|....|.|:::.|         |||:         .:...|||              :|
Human  1182 SGVKNKLCVAALSVNNFCD---------NREA---------LYGVFDGDRNVEVPYLLQCTMSDI 1228

  Fly   945 MIKDLHPTQATTNEDD---NTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKI-GIAHGP 1005
            :.::|   |.|.||::   ||.:||.          |.:.:.|      .||.|:..: .|.|.|
Human  1229 LAEEL---QKTKNEEEYMVNTFIVMQ----------RKLGTAG------QKLGGAAVLCHIKHDP 1274

  Fly  1006 VMAG 1009
            |..|
Human  1275 VDPG 1278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850
		CYCc	812..1051	CDD:214485	54/250 (22%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	47/214 (22%)
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380	4/21 (19%)
		PP2Cc	1168..1420	CDD:214625	32/148 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470
		PH_PHLPP-like	535..631	CDD:270131
		PH	555..636	CDD:278594
		LRR_RI	625..929	CDD:238064	49/253 (19%)
		LRR_8	638..703	CDD:290566
		LRR 1	638..659
		leucine-rich repeat	641..661	CDD:275380
		LRR 2	661..682
		leucine-rich repeat	662..692	CDD:275380
		LRR 3	692..712
		leucine-rich repeat	693..738	CDD:275380	127/654 (19%)
		LRR_8	714..770	CDD:290566	10/35 (29%)
		LRR 4	715..736
		LRR 5	738..760		8/24 (33%)
		leucine-rich repeat	739..761	CDD:275380	7/24 (29%)
		LRR 6	761..783		5/23 (22%)
		leucine-rich repeat	762..784	CDD:275380	5/23 (22%)
		LRR 7	784..804		4/19 (21%)
		leucine-rich repeat	785..808	CDD:275380	6/22 (27%)
		LRR 8	808..831		5/22 (23%)
		leucine-rich repeat	810..832	CDD:275380	4/21 (19%)
		LRR_RI	814..1074	CDD:238064	53/325 (16%)
		LRR 9	832..853		7/37 (19%)
		leucine-rich repeat	833..853	CDD:275380	6/36 (17%)
		leucine-rich repeat	854..895	CDD:275380	8/81 (10%)
		LRR 10	873..894		5/26 (19%)
		LRR 11	895..916		6/20 (30%)
		leucine-rich repeat	896..918	CDD:275380	6/21 (29%)
		LRR 12	918..939		5/20 (25%)
		leucine-rich repeat	919..941	CDD:275380	6/21 (29%)
		LRR 13	941..962		1/20 (5%)
		leucine-rich repeat	942..963	CDD:275380	1/20 (5%)
		LRR_8	962..1024	CDD:290566	12/69 (17%)
		LRR 14	963..984		5/20 (25%)
		leucine-rich repeat	964..987	CDD:275380	6/23 (26%)
		LRR 15	987..1008		3/27 (11%)
		leucine-rich repeat	988..1011	CDD:275380	3/29 (10%)
		LRR 16	1013..1033		2/19 (11%)
		LRR_8	1014..1072	CDD:290566	10/57 (18%)
		leucine-rich repeat	1014..1037	CDD:275380	3/22 (14%)
		LRR 17	1037..1058		4/20 (20%)
		leucine-rich repeat	1038..1061	CDD:275380	5/22 (23%)
		LRR 18	1061..1082		4/20 (20%)
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205		29/151 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900