DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and Adcy5

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_001012783.3	Gene:	Adcy5 / 224129	MGIID:	99673	Length:	1262	Species:	Mus musculus

Alignment Length:	1162	Identity:	309/1162 - (26%)
Similarity:	500/1162 - (43%)	Gaps:	249/1162 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVK---NIDFLTVLPYFAVMLLTPSIL 95
            :||.:|.|:...::.:.:|.|:.|:.::.|  |:|.|...:   .|.:|.||.....::|..::|
Mouse   226 KLERLYQRYFFRLNQSSLTMLMAVLVLVCL--VMLAFHAARPPLQIAYLAVLAAAVGVILIMAVL 288

  Fly    96 MPSREPNVEQYESIAILVSCLMALLLTAMDLILPICYFRPFSLVPSYDHVV--IVLIYLMFPI-- 156
            . :|....:.:..:|......:.|.:..:.|:||    :|.|........|  |..||.:.|:
Mouse   289 C-NRAAFHQDHMGLACYALIAVVLAVQVVGLLLP----QPRSASEGIWWTVFFIYTIYTLLPVRM 348

  Fly   157 -AFVKNG-RAYFLGLAVSLF-----YFGYMALIDKI---STLDKVWELTAYGAYLFFLNMLCMFL 211
             |.|.:| ....|.||:||.     .|....|:..:   |..:.|...|.|.|
Mouse   349 RAAVLSGVLLSALHLAISLHTNSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPA------------ 401

  Fly   212 SRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSNLMP 276
                |.:.|.......:.:...|..|...::::.||.|::|..:|..::..|.:..|:     |.
Mouse   402 ----EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQED-----MM 457

  Fly   277 FTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGD 341
            |.|   ::::.|..||||.||:..||.|.:.....:||..|:|||..||..|..|...|||.|||
Mouse   458 FHK---IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD 519

  Fly   342 SYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFD 406
            .|.||:|:|.....||:.||...:||||....|.:.....:::|:|:|||.:..|::||.|||||
Mouse   520 CYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFD 584

  Fly   407 IWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLP 471
            :||.||.:.|.:|:.|..|.:||:..||..|:..|..|.|....: :..|:..::.|:||.|
Mouse   585 VWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGDR-NAYLKEHSIETFLILS--- 645

  Fly   472 NFEDTDDLEDDNFSLNDYRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCKIRR-----PM 531
               .|...:::...:.......:.|..:......|:|..   ..|:..|:|.. :::|     |.
Mouse   646 ---CTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPF---YNHLGGNQVSK-EMKRMGFEDPK 703

  Fly   532 HRIAKEDINEEYRF-------------------HLESYYLFTTFRSWRMEWSFNKMRD------- 570
            .:.|:|..|.|...                   |:..:.|  |||...:|..::|..|
Mouse   704 DKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLL--TFREPDLEKKYSKQVDDRFGAYV 766

  Fly   571 ----LLMKYSLGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLS 631
                |:..:    :.|...||:...|.:.|   .|...|.|..|::...::.:..||:
Mouse   767 ACASLVFLF----ICFVQITIVPHSLFMLS---FYLSCFLLLALVVFVSVIYACVKLF------- 817

  Fly   632 PITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFL-----LYVMSSETVFSCDIARLELEIIN 691
              ..|...|||..:::.   :.|..|.: ..|.::||     :::.:|:.:..|          .
Mouse   818 --PTPLQTLSRKIVRSK---KNSTLVGV-FTITLVFLSAFVNMFMCNSKNLVGC----------L 866

  Fly   692 SELHNL---------------------------RPQMLCFMPWGVTYAVVIVLSLMLVIIGIPLI 729
            :|.||:                           .||..|..|...||:|::.|....|.:.|..|
Mouse   867 AEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQPNCNFPEYFTYSVLLSLLACSVFLQISCI 931

  Fly   730 IKLGVGLAILGSHVITVHAYYGFAFERSQT---------TNIGVTSSLAHSWYMVAFFIV--VVV 783
            .||.:.|||...:|:.|.......|:.:..         :|.|.:....|: ..||..:|  :::
Mouse   932 GKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHA-TKVALKVVTPIII 995

  Fly   784 REGYLNYILKASYFMS----------MCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVR-RR 837
            ....|...|.|....|          ...|:|.|:.:::... :.::.||||..||..|..| ||
Mouse   996 SVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYN-RRLLHNILPKDVAAHFLARERR 1059

  Fly   838 SDQLYYENFSQVAVMFATIENY-------EADKSG---LRALHEMICYFDELLVNYQSWYKIEKI 892
            :|:|||::...||||||:|.|:       ||:..|   ||.|:|:|..||| :::...:.::|||
Mouse  1060 NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDE-IISEDRFRQLEKI 1123

  Fly   893 KVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTN 957
            |.:|.||:||.||:...|               ||..|:                  |
Mouse  1124 KTIGSTYMAASGLNDSTY---------------DKAGKT------------------H------- 1148

  Fly   958 EDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWG 1022
                 |..:.:||:.|:..::       :..:.|.....:|||:..|||:|||:|..||.|||||
Mouse  1149 -----IKAIADFAMKLMDQMK-------YINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG 1201

  Fly  1023 HTVNMASRMTSTGVRDGIHVTESTANVL--RDFNIRCTYRGMTFVKGVGQVPTYLVD 1077
            :|||:||||.||||.|.|.||.....||  ..:.:.|  ||:..|||.|::.||.::
Mouse  1202 NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYFLN 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	66/155 (43%)
		CYCc	812..1051	CDD:214485	88/251 (35%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	86/246 (35%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831	57/260 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194
		CYCc	425..620	CDD:214485	76/202 (38%)
		Guanylate_cyc	461..622	CDD:278633	67/160 (42%)
		DUF1053	669..761	CDD:283888	19/97 (20%)
		CYCc	1037..1238	CDD:214485	88/254 (35%)
		Guanylate_cyc	1063..1257	CDD:278633	86/249 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000