Protein Alignment CG32301 and ADCY4

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_001185497.1
• Gene: ADCY4 / 196883
• HGNCID: 235
• Length: 1077
• Species: Homo sapiens
• Alignment Length: 1155
• Identity: 307/1155 - (26%)
• Similarity: 478/1155 - (41%)
• Gaps: 248/1155 - (21%)

  Fly    54 LIIVIEILMLIHVILLFSVVKNIDFLTVLPYFAVMLLTP----SIL--MPSREPNVEQYESIAIL 112
            |::::.|::.....||.....:...||..|.|...:|..    |:|  :.|||..::::
Human    30 LLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQRLQRW------ 88

  Fly   113 VSCLMALLLTAMDLILPICYFRPFSLVPSYDHV-----VIVLIYLMFPIAFVKNGRAYFLGLAVS 172
            ...|..|:..|: |.|...:.....:|.::|.|     ||...|.|.|:..   ..|...|||.|
Human    89 TRPLSGLVWVAL-LALGHAFLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGM---RDAAVAGLASS 149

  Fly   173 L-------FYFGYM-----ALIDKISTLDKVWELTAYGAYLFFL-NMLCMFLSRFQEYNMRSGIL 224
            |       .|.|..     ||:.::          |..|.||.. |:..::.....|..:|:...
Human   150 LSHLLVLGLYLGPQPDSRPALLPQL----------AANAVLFLCGNVAGVYHKALMERALRATFR 204

  Fly   225 SRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSNLMPFTKTRH-LFMEPH 288
            .....::.........|.::.||.||:|..|||.::..|.:.::....:....|...| |:::.|
Human   205 EALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRH 269

  Fly   289 PEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYF 353
            ..||:|.||:|.||.|.:.....:||.:|:|||..||..|..:...|||.|||.|.||:|:|...
Human   270 QGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSL 334

  Fly   354 PTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRL 418
            |.||..||...|||....|::.......|::|:|||||.:|.|:|||.|||:|:||.||.:.|.:
Human   335 PDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHM 399

  Fly   419 ESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDD----- 478
            |:.|:||.|||:..||.||...|..|: ......||.|:.....|||:..  |..|:.|:
Human   400 EAGGVPGRVHITGATLALLAGAYAVED-AGMEHRDPYLRELGEPTYLVID--PRAEEEDEKGTAG 461

  Fly   479 -----LED----DNFSLNDYRFSF----------------------------SFSQDYEDIQVKA 506
                 ||.    .:..:..|..|:                            |||..:...:.:.
Human   462 GLLSSLEGLKMRPSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRT 526

  Fly   507 QRDMILEVEHMPVNRVQTCKIRRPMHRIAKEDINEEYRFHLESYYLFTTFRSWRMEWSFNKM--- 568
            .|.:..|::.......|..           |.:|.:              :.|:....||.:
Human   527 PRGLDDELDTGDAKFFQVI-----------EQLNSQ--------------KQWKQSKDFNPLTLY 566

  Fly   569 ---RDLLMKYSLG------------MMVFAGATIIAMDLLVKSE----AMDYTMLFSLFLLILLP 614
               :::..:|.|.            .:||....||.|  ||.:.    |:.|::.|.||||||..
Human   567 FREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQM--LVTNRPPALAITYSITFLLFLLILFV 629

  Fly   615 LLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVF- 678
            .......:..|:|.:          :..|....|.|:.....:||.|....:.|::.|:..::|
Human   630 CFSEDLMRCVLKGPK----------MLHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFF 684

  Fly   679 --------------SCDIARLELEIINS-ELHNLRPQMLC----FMPWGVTYAVVIVLSLMLVII 724
                          |..|:.|..|:..| .|.::...|.|    |:...:...:...|.|:|:::
Human   685 FPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLL 749

  Fly   725 GIPLIIKLGVGLAILGSHV-----ITVHAYYGFAFERSQTTNIGVTSSL----AHSWYMVAFFIV 780
            .:.....|     .|.||.     :.|..|.|....|.     ||....    |.|:::..|.::
Human   750 WLAASCSL-----FLHSHAWLSECLIVRLYLGPLDSRP-----GVLKEPKLMGAISFFIFFFTLL 804

  Fly   781 VVVREGYLNYILKASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVF-KVRRRSDQLYYE 844
            |:.|:.  .|..:..:.......::.|.|:......::::.|:||.|||..| ...||::.||::
Human   805 VLARQN--EYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQ 867

  Fly   845 NFSQVAVMFATIENYEADKSG----------LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTY 899
            ::..|.|:||::.:::...|.          ||.|:|:|..||||| :...:..:||||.:|.||
Human   868 SYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELL-SKPKFSGVEKIKTIGSTY 931

  Fly   900 LAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTIL 964
            :||.||:.....|                                       .|.......:.:.
Human   932 MAATGLNATSGQD---------------------------------------AQQDAERSCSHLG 957

  Fly   965 VMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMAS 1029
            .|.|||:.|       .||.....|.|.....|::|:.||||:|||:|..||.|||||:|||:||
Human   958 TMVEFAVAL-------GSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVAS 1015

  Fly  1030 RMTSTGVRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLVDLD 1079
            ||.||||...|.|||.||..|:.....|..||:..|||.||:.||.::.|
Human  1016 RMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTD 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	72/155 (46%)
		CYCc	812..1051	CDD:214485	82/249 (33%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	84/244 (34%)
ADCY4	NP_001185497.1	AC_N	<115..246	CDD:292831	34/143 (24%)
		CYCc	219..422	CDD:214485	84/202 (42%)
		Guanylate_cyc	264..418	CDD:278633	70/153 (46%)
		DUF1053	479..583	CDD:283888	15/128 (12%)
		CYCc	827..1042	CDD:214485	85/261 (33%)
		Guanylate_cyc	864..1063	CDD:278633	84/245 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.970