DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and gcy-25

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_001294116.1	Gene:	gcy-25 / 191653	WormBaseID:	WBGene00001549	Length:	1034	Species:	Caenorhabditis elegans

Alignment Length:	382	Identity:	85/382 - (22%)
Similarity:	155/382 - (40%)	Gaps:	78/382 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 YFAVMLLTP----SILMPSREPNVEQYESIAILVSCLMALLLTAMDLILPICYFRPFSLVPSYDH 144
            ::..:.|.|    :||....||.......|..|..|:..:|.          |.|||:   ....
Worm   638 HYKYLQLAPEHISAILEKLEEPRGTVEGDIYQLAMCIYQILF----------YMRPFA---ERQE 689

  Fly   145 VVIVLIYLM-----FPI-AFVKNGRAYFLGLAVSLFYFGYM-------ALIDKISTLDKVWELTA 196
            .:..|.:|:     .|: ..|..|.::.:.| :|:....::       |||.....:::.:....
Worm   690 SIKELAHLLSSQSTAPLHPKVPEGNSFTMRL-LSIIQQCWLYKPAARPALIKITDAVNREFGQDV 753

  Fly   197 YGAYLFFLNMLCMFLSRFQEYNM--------RSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPV 253
            .|      .::...:....||:.        |:..|.:...|.:||::|:
Worm   754 KG------TLIDQMIEMIDEYSANLEQIVAERTRELEQDMSVTENLLYQL--------------- 797

  Fly   254 TLARSLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILH 318
             |.:|:.|:|.|     ...::|         |.|..|::|..|:..||..........::..|.
Worm   798 -LPKSVADSIRS-----GKTVVP---------EQHSSVTLLVVDVCQFTKFCEAFIPVHILETLQ 847

  Fly   319 ELFVSFDLAANHNRATRIKFLGDSYTCVTGIP--SYFPTHANAC-VNQALDMIEISREVSKRRNK 380
            ||:.|||.....|:|.:::.:||:|...:|||  |.|......| ::..|.....:.:|..|.:.
Worm   848 ELYSSFDNIVQKNKAFKVENVGDAYLICSGIPEMSGFRHLREICKISLKLQAFMKTFKVRHRPSH 912

  Fly   381 KIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLL 437
            .:.:::|:.||.:.|||:|.|..:|.|:...|::..|:.|:|.||.:.:|..|...|
Worm   913 TLQIKMGITSGAVAAGILGSTAPRFCIFGDTVNMACRMASTGNPGSIQLSELTANTL 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	46/158 (29%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
gcy-25	NP_001294116.1	PBP1_iGluR_N_LIVBP_like	56..>230	CDD:107346
		PKc_like	473..746	CDD:304357	24/121 (20%)
		SPS1	474..>736	CDD:223589	21/111 (19%)
		HNOBA	<764..805	CDD:285003	10/56 (18%)
		CYCc	790..976	CDD:214485	55/210 (26%)
		Nucleotidyl_cyc_III	812..999	CDD:299850	47/167 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900