Protein Alignment CG32301 and gcy-21

DIOPT Version :10

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_001364740.1
• Gene: gcy-21 / 191651
• WormBaseID: WBGene00001546
• Length: 1163
• Species: Caenorhabditis elegans
• Alignment Length: 1138
• Identity: 208/1138 - (18%)
• Similarity: 362/1138 - (31%)
• Gaps: 441/1138 - (38%)

  Fly    69 LFSVVKNIDFLTVLPYFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDLILPICYF 133
            |..|.||:..|:..|             |..||| ..:|.|...|     |:.....:..|.|..
 Worm   302 LHEVYKNVVILSDGP-------------PPAEPN-STWEDIKSQV-----LMKKPAKMCPPYCNT 347

  Fly   134 R-PFSLVPSYDHVVIVLIYLMFPIAFVKNGR--------------AYFLG------LAVSLFYFG 177
            . ...:.|.:|.:.::...:.: :|...|..              .|.:.      ..|:.|..|
 Worm   348 TVSEKITPRWDRIKLLFDSIQY-LADATNDALNIGANIYQSDIFYEYLISRKIDSVTGVTEFIDG 411

  Fly   178 YMALIDKI-------------------------STLDKVWELTAYG------------------- 198
            |.|::..|                         |.|:.||.||.|.
 Worm   412 YGAIVGSIQIYYHFSSSSHNSYSLFPCARLAQSSLLNTVWSLTDYSEGLSIDFVNKSAPKDTPVC 476

  Fly   199 -----------------------AYLFFLNMLCMFLSRFQEYNMRSG----ILSRYQVV---YQN 233
                                   |.|..|.:...||.:...|..|..    ::.|.|::   :.|
 Worm   477 GFYGENCGPPANNTFIIVISVGVAVLIGLAIAAAFLYKRYRYERRLHSLFFMIDRNQIILKKHTN 541

  Fly   234 LVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADM 298
            |:.|.:::...::..|:  |..:::|:|:                   |.|:|.:...|.:.|..
 Worm   542 LMSQQSLRSMASIHGSV--VAASQTLRDS-------------------HFFIEDYNNASSINASS 585

  Fly   299 VDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLG--DSYTCVTGIPSYFPTHANACV 361
            :..||.|                            .|....|  ..:..|||...
 Worm   586 IFNTGST----------------------------ARAGPFGPIPGFGGVTGASE---------- 612

  Fly   362 NQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITN--RLESSGLP 424
                         .::.::..|..:|::.|..:|    |.:    |:..||:.|.  |||.:.|.
 Worm   613 -------------DEKWHQIPDFGVGLYEGRTVA----LKR----IYRSDVEFTRSIRLEIAKLQ 656

  Fly   425 GMVHIS-SRTLGLL----DNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLEDDNF 484
            ..|:.: ...:|::    |...|||          |.||.:|.              |.|::|:.
 Worm   657 ESVNSNVIEFVGMVVQSPDVFVVYE----------LAQRGSLK--------------DILDNDDM 697

  Fly   485 SLNDYRFSFSFSQDYEDIQVKAQRDMILEVEHM---PVN-----RVQTCKI-RRPMHRIAKEDIN 540
            .|:|.            .:.:..:|:|..:|::   |:.     :...|.| .|.|.|::...:.
 Worm   698 PLDDV------------FRSQMTKDIIAGLEYLHSSPIGCHGRLKSTNCLIDARWMVRLSSFGLR 750

  Fly   541 EEYRFHLESYYLFTTFRSWRMEWSFNKMRDL------LMKYSLGMMVFAGATIIAMDLLVKSEAM 599
            |           .....:|:.|....:.:|.      |:::|.|:      :...:.|:.||:.
 Worm   751 E-----------LRGEETWQQEDDVQEGKDQLWTSPELLRWSTGL------SQCGVLLVQKSDV- 797

  Fly   600 DYTMLFSLFLLILLPLLLASYKKLWLRGRRLSP----ITQPTFFLSRWFIKASDLIEKSVFVRIP 660
             |::...|:.|.                .||.|    ..:|...:|  .:|...|..|..| |..
 Worm   798 -YSLAIVLYELF----------------GRLGPWGDEPMEPREIVS--LVKREALAGKKPF-RPD 842

  Fly   661 LAIMVLFLLYVMSSETVFSCDIARLELEIINSELHNLRPQMLCFMPWGVTYAVVIVLSLMLVIIG 725
            :|::......|  .|||.:   |..|..:....||.::.::.
 Worm   843 MAVLKESPRIV--QETVVA---AWTEDPLNRPSLHQIKRKLK----------------------- 879

  Fly   726 IPLIIKLGVGLAILGSHVITVHAYYGFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNY 790
             ||.|  |:...|:.:.|..:..|               |..|...   :|
 Worm   880 -PLTI--GLKRTIMDNMVSMIEKY---------------TDKLEKD---IA-------------- 909

  Fly   791 ILKASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVRRRSDQLYYENFSQVAVMFAT 855
                        |:..||...|.:: :.::..:||..||:..|:   ...:..|:|....|.|:.
 Worm   910 ------------ERNEELEGEKAKS-EALLKMMLPEVVADSLKL---GSNVSAESFENCTVFFSD 958

  Fly   856 IENY-EADKSG-----LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFS 914
            ...: |...:.     ::.|:::...||.::..:.. ||:|.|   ...|:.|.||.|.
 Worm   959 CPGFVEMSATSKPIDIVQFLNDLYTVFDRIIDQFDV-YKVETI---ADAYMVASGLPVP------ 1013

  Fly   915 VSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRD 979
                 :.|..:.::...|                                      |.||:.:..
 Worm  1014 -----NGNHHAGEIASLG--------------------------------------LALLKAVES 1035

  Fly   980 IRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTE 1044
            .:.:.:..||     ..|:||:..||.:||||||..|.|.::|.|||.||||.|.|:...|:.:.
 Worm  1036 FKIRHLPNEK-----VRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSG 1095

  Fly  1045 STANVLRDF-NIRCTYRGMTFVKGVGQVPTYLV 1076
            :...:|... ......||:..:||.|:..||.|
 Worm  1096 TAKEILDQLGGYEIEERGIVEMKGKGKQMTYFV 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	81/479 (17%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	27/164 (16%)
		AcyC	681..1076	CDD:441717	79/401 (20%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	56/241 (23%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:471960	27/139 (19%)
		PK_GC	612..881	CDD:270894	69/402 (17%)
		HNOBA	<890..938	CDD:462234	13/92 (14%)
		Guanylate_cyc	944..1130	CDD:425528	57/243 (23%)