DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32301 and gcy-17

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_001293327.1	Gene:	gcy-17 / 191649	WormBaseID:	WBGene00001542	Length:	1088	Species:	Caenorhabditis elegans

Alignment Length:	399	Identity:	86/399 - (21%)
Similarity:	165/399 - (41%)	Gaps:	116/399 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 YLMFPIAFVKNGRAYFLGLAVSLFYF-GYMAL-----------------------IDKISTLDKV 191
            :::..|..:.||..:   :..|:.:| ||::.                       :||:||.:.:
Worm   645 FMLSLIRDIANGLGF---IHTSMLHFHGYLSSRSCLIDDRWQVKISDFGLNEVRGMDKLSTENML 706

  Fly   192 W---------ELTAYGAYLFFLNMLCM-FLSRFQEYNMRSGILSRYQVVYQ-----------NLV 235
            |         |..:..|.::...::|. .::|...:::.:......:::||           :|:
Worm   707 WWAPEVLRGLEQRSKEADIYSFGIICSEVITRSSAFDLENRKEKPEEIIYQLKKGGFNAIRPSLL 771

  Fly   236 FQMAMKEEKALLDSI-----------IPVTLARSL-------------------QDAIASHIEED 270
            ...|::...||:..|           .|:...|||                   .:..||.:||:
Worm   772 TDEALEINPALVHLIRDCWTEKPSERPPIDQVRSLLRGMNDGKKGNLMDHVFNMLETYASTLEEE 836

  Fly   271 PS------------------NLMPFTKTRHL----FMEPH--PEVSILEADMVDFTGLTTTMEVS 311
            .:                  .::|.|....|    .:||.  ..|:|..:|:|.||.|.:.....
Worm   837 VNERTKELVEEQKKSDVLLYRMLPKTVAEKLKAGISIEPETFELVTIFFSDVVQFTTLASKCTPL 901

  Fly   312 DLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANA------CVNQALDMIEI 370
            .:|.:|::|:..||.....|...:::.:||.|.||:|:|     |.|.      ....:|..:..
Worm   902 QVVQLLNDLYTIFDSIIEQNDVYKVETIGDGYLCVSGLP-----HRNGHDHIKHIARMSLAFLSS 961

  Fly   371 SRE--VSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRT 433
            ..|  |:...:::|:||||::.|.::||::|||..::.::...|:..:|:||:|.||.:|:||..
Worm   962 LAEFRVAHMPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGRIHVSSEA 1026

  Fly   434 LGLLDNHYV 442
            ..|| .|.|
Worm  1027 NHLL-THVV 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	51/169 (30%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
gcy-17	NP_001293327.1	Periplasmic_Binding_Protein_Type_1	25..404	CDD:299141
		ANF_receptor	47..398	CDD:279440
		PKc_like	539..808	CDD:304357	27/165 (16%)
		Pkinase	567..803	CDD:278497	24/160 (15%)
		HNOBA	<824..867	CDD:285003	6/42 (14%)
		CYCc	846..1038	CDD:214485	55/195 (28%)
		Guanylate_cyc	873..1060	CDD:278633	52/168 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900