DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and gcy-15

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	986	Identity:	183/986 - (18%)
Similarity:	330/986 - (33%)	Gaps:	369/986 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PICYFRPFSLVPSYDHVVIVLIYLMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDKVWE 193
            |:|.|...:..|..::..|::|.:         |.|..:|||::..:.
Worm   415 PVCGFYGENCGPPANNTFIIVISV---------GVAVLIGLAIAAAFL----------------- 453

  Fly   194 LTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVV---YQNLVFQMAMKEEKALLDSIIPVTL 255
               |..|.:...:..:|.           ::.|.|::   :.||:.|.:::...::..|:  |..
Worm   454 ---YKRYRYERRLHSLFF-----------MIDRNQIILKKHTNLMSQQSLRSMASIHGSV--VAA 502

  Fly   256 ARSLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHEL 320
            :::|:|:                   |.|:|.:...|.:.|..:..||.|
Worm   503 SQTLRDS-------------------HFFIEDYNNASSINASSIFNTGST--------------- 533

  Fly   321 FVSFDLAANHNRATRIKFLG--DSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKID 383
                         .|....|  ..:..|||...                       .::.::..|
Worm   534 -------------ARAGPFGPIPGFGGVTGASE-----------------------DEKWHQIPD 562

  Fly   384 LRIGVHSGEILAGIIGLTKWQFDIWSKDVDIT--NRLESSGLPGMVHIS-SRTLGLL----DNHY 441
            ..:|::.|..:|    |.:    |:..||:.|  ||||.:.|...|:.: ...:|::    |...
Worm   563 FGVGLYEGRTVA----LKR----IYRSDVEFTRSNRLEIAKLQESVNSNVIEFVGMVVQSPDVFV 619

  Fly   442 VYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLEDDNFSLNDYRFSFSFSQDYEDIQVKA 506
            |||          |.||.:|.              |.|::|:..|:|.            .:.:.
Worm   620 VYE----------LAQRGSLK--------------DILDNDDMPLDDV------------FRSQM 648

  Fly   507 QRDMILEVEHM---PVN-----RVQTCKI-RRPMHRIAKEDINEEYRFHLESYYLFTTFRSWRME 562
            .:|:|..:|::   ||.     :...|.| .|.|.|::...:.|           .....:|:.|
Worm   649 TKDIIAGLEYLHSSPVGCHGRLKSTNCLIDARWMVRLSSFGLRE-----------LRGEETWQQE 702

  Fly   563 WSFNKMRDL------LMKYSLGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLASYK 621
            ....:.:|.      |:::|.|:      :...:.|:.||:.  |::...|:.|.
Worm   703 DDVQEGKDQLWTSPELLRWSTGL------SQCGVLLVQKSDV--YSLAIVLYELF---------- 749

  Fly   622 KLWLRGRRLSP----ITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCDI 682
                  .||.|    ..:|...:|  .:|...|..|..| |..:|::......|  .|||.:
Worm   750 ------GRLGPWGDEPMEPREIVS--LVKREALAGKKPF-RPDMAVLKESPRIV--QETVVA--- 800

  Fly   683 ARLELEIINSELHNLRPQMLCFMPWGVTYAVVIVLSLMLVIIGIPLIIKLGVGLAILGSHVITVH 747
            |..|..:....||.::.::.                        ||.|  |:...|:.:.|..:.
Worm   801 AWTEDPLNRPSLHQIKRKLK------------------------PLTI--GLKRTIMDNMVSMIE 839

  Fly   748 AYYGFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEKKHELTKVK 812
            .|               |..|...   :|                          |:..||...|
Worm   840 KY---------------TDKLEKD---IA--------------------------ERNEELEAEK 860

  Fly   813 TRTIKIIMANILPTHVAEVFKVRRRSDQLYYENFSQVAVMFATIENY-EADKSG-----LRALHE 871
            .:: :.::..:||..||:..|:   ...:..|:|....|.|:....: |...:.     ::.|::
Worm   861 AKS-EALLKMMLPEVVADSLKL---GSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQFLND 921

  Fly   872 MICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRF 936
            :...||.::..:.. ||:|.|   ...|:.|.||.|.           :.|..:.::...|
Worm   922 LYTVFDRIIDQFDV-YKVETI---ADAYMVASGLPVP-----------NGNHHAGEIASLG---- 967

  Fly   937 APMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGI 1001
                                              |.||:.:...:.:.:..||     ..|:||:
Worm   968 ----------------------------------LALLKAVESFKIRHLPNEK-----VRLRIGM 993

  Fly  1002 AHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDF-NIRCTYRGMTFV 1065
            ..||.:||||||..|.|.::|.|||.||||.|.|:...|:.:.:...:|... ......||:..:
Worm   994 NSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLGGYEIEERGIVEM 1058

  Fly  1066 KGVGQVPTYLV 1076
            ||.|:..||.|
Worm  1059 KGKGKQMTYFV 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	28/164 (17%)
		CYCc	812..1051	CDD:214485	54/244 (22%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	56/241 (23%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822
		PK_GC	553..822	CDD:270894	71/402 (18%)
		HNOBA	<831..879	CDD:400168	13/92 (14%)
		Guanylate_cyc	885..1071	CDD:306677	57/243 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900