Protein Alignment CG32301 and acy-2

DIOPT Version :10

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_504553.1
• Gene: acy-2 / 191607
• WormBaseID: WBGene00000069
• Length: 1080
• Species: Caenorhabditis elegans
• Alignment Length: 1106
• Identity: 306/1106 - (27%)
• Similarity: 474/1106 - (42%)
• Gaps: 211/1106 - (19%)

  Fly    84 YFAVMLLTPSILMPSREPNVEQYESIA-ILVSCLMALLLTAMDLI--LPICYFRPFSLVPSYDH- 144
            :|...|:.....:..|:|.    |.:. :|||..:.:||.|...|  ||:..|.....:.:.:|
 Worm    88 FFIAYLILTCFAIRIRQPK----EGMGLVLVSLSLCVLLPAFSWILHLPVVIFVSRERIHTNEHD 148

  Fly   145 ---------VVIVLIYLMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTAYGAY 200
                     :..|:.:.:.|    ::.|.:|: :|||.....:: ||..|:     |:......
 Worm   149 HSALYTSLCIASVIQFFILP----RHRRIFFV-VAVSWIVANFL-LIVAIN-----WDALNVNT- 201

  Fly   201 LFFLNMLCMFLSR-----------FQEYNMRSGILSRY-QVVYQNLVFQMAMKEEKALLDSIIPV 253
            ||..:.|.:||.:           ..|...|:.|..:. :.||:....:.....::.||.|:||.
 Worm   202 LFMCSCLSLFLHQGVIALVGVVADSNEAGNRAEIARKLTEAVYRRTELETLKDRQEQLLLSVIPA 266

  Fly   254 TLARS-----LQDAIASHIEEDPSNLMPFTKTRHLF----MEPHPEVSILEADMVDFTGLTTTME 309
            .||..     :|.:......|.|......||...||    ::.|..||||.||:|:||.|...:.
 Worm   267 YLADQVSKSIIQSSSTGSTVEVPRTGKNNTKNHKLFHDLHVQVHDNVSILFADIVNFTVLAAQLT 331

  Fly   310 VSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREV 374
            ..|||..|:||:..||..|...:..|||||||.|.||:|:|...|.||:.||...|:||...::|
 Worm   332 AKDLVRTLNELYSKFDRDAQRLQCMRIKFLGDCYYCVSGMPVNRPNHADMCVVMGLEMINTIKQV 396

  Fly   375 SKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLG-LLD 438
            .......:::|||||:|.:|.||:||.||||||||.||.:.|.:||:|:||.|||:..|.. ||.
 Worm   397 RIATGVDVNMRIGVHTGSVLCGIMGLRKWQFDIWSDDVTLANHMESAGVPGAVHITKSTKDMLLG 461

  Fly   439 NHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLEDDNFSLNDYRFSFS--------- 494
            ::.:.:..||    ||.:......||.|   ||  :.|..:|.......:.|.|.|
 Worm   462 DYCIVDANTD----DPHVVSYGQPTYHI---LP--DKTSAIERTASIYRNSRLSTSPALQSRMSM 517

  Fly   495 ----------------FSQDYEDIQVKAQRDMIL---EVEHMP--VNRVQTCK-IRRPMHRIAKE 537
                            |: ::...:..|..|..|   |:...|  :|.:.:.. |...:...:..
 Worm   518 KAKVSKMVEFWGAETPFA-NFTKKKFSASHDPALITDEIARRPTYINTIPSMTLIENNLTNFSFN 581

  Fly   538 DINEEYRFHLESYYLFTTFRSWRMEWSFNKMRDLLMKYSLGMMVF-----AGATIIAMDLLVKSE 597
            :||..:...|.     |...|.::.|.|::...........::.|     |.|.::...|...|:
 Worm   582 NINSMFNCELP-----TIPASPKLLWPFSRKSITCNLSDCVLLTFVCIPSAFANLLLCSLYCPSD 641

  Fly   598 AMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLS---P-ITQPTFFLSRWF-IKASDLIEKSVFV 657
            .:....|...|.:|.|.:|.       |.||..|   | ||...|.||... |....:|:||...
 Worm   642 VLQQISLQQFFTIIGLAMLS-------LLGRVCSYAGPLITMVAFLLSSCIPIGPHIIIKKSKLE 699

  Fly   658 RIPLAIMVLFLLYVMSSETVFSCDIARLELEIINSELHNLRPQMLCFMPWGVTYAVVIVLSLMLV 722
            .:.....::||.         || ::.|....|   |:.|.....||:    .:|..::..::|.
 Worm   700 GVMAFNSLIFLP---------SC-VSHLVSVFI---LYRLPYSHRCFL----FFADFVIFQVLLS 747

  Fly   723 IIGIPLIIKLGVGLAILGSHVITVHAYYGFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGY 787
            :            ....|:.|..  .|.|:        ::.|.|.......::.|||     :..
 Worm   748 L------------FPAYGAEVYV--GYMGY--------HLSVVSISLSLLVVLLFFI-----DWI 785

  Fly   788 LNYILKASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVF-KVRRRSDQLYYENFSQVAV 851
            .||..|......:.|:.:....:......||::.||||:.||..| ...|..::||......|.|
 Worm   786 TNYERKRESACHVSFQNEERDVETMQDINKILIENILPSSVAAKFLSPDRAVNELYARQHENVCV 850

  Fly   852 MFATIENY-----EADKSG----LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHV 907
            |||:|.|:     |.|.:.    ||.|:|::|.||:|| :...:..:||||.:|.||:||.||:.
 Worm   851 MFASIPNFKDFWSEWDTNRKLECLRLLNEIVCEFDKLL-SKPKFSSVEKIKTVGSTYMAAAGLNE 914

  Fly   908 DH--YTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFA 970
            ..  |.|.             .|:|..|.::    .:.|.    |...|..|.:     :|.|||
 Worm   915 SEADYDDI-------------YLEKQNSGKY----NNNIR----HGNMAFRNAN-----LMIEFA 953

  Fly   971 LNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTG 1035
            |.:.:||..:       .:||.....|:||::.||::|||:|..||.|||||:|||:||||.:.|
 Worm   954 LAMSQILDAL-------NRDSFQNFELRIGMSVGPLVAGVIGAQKPQYDIWGNTVNLASRMDTHG 1011

  Fly  1036 VRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQ-VPTYLVDLDENLHF------QQHSPDNDS 1093
            ....||.|.....||:....|...||...||||.: :.|:|:::|...:.      |.||.:|:.
 Worm  1012 EPRKIHATTDMGRVLQTGGYRVQSRGKIRVKGVKEPMETFLIEVDSKRNSSVSGEQQNHSNNNNC 1076

  Fly  1094 H 1094
            |
 Worm  1077 H 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	125/395 (32%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	76/160 (48%)
		AcyC	681..1076	CDD:441717	117/407 (29%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	86/246 (35%)
acy-2	NP_504553.1	Guanylate_cyc	307..486	CDD:425528	81/185 (44%)
		Guanylate_cyc	840..1054	CDD:425528	87/247 (35%)