DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and daf-11

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_505960.3	Gene:	daf-11 / 179605	WormBaseID:	WBGene00000907	Length:	1077	Species:	Caenorhabditis elegans

Alignment Length:	786	Identity:	155/786 - (19%)
Similarity:	267/786 - (33%)	Gaps:	274/786 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 LRIGVHSGEILAGIIGLT----------------KWQF---DIWSKDVDITNRLESSGLPGMVHI 429
            :.|.|..|.:|..||.||                .|..   |:  :.:|:||      ..|..|:
Worm   339 IAIAVIMGVLLMFIIILTTIRKCCNGSKGRSISNPWVIPFQDV--RFIDLTN------TEGSQHM 395

  Fly   430 SSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLST----------YLIRSRLPNFEDTD------- 477
            |.::|        .....:..:|..|.:..:::|          |::|.:| .::..|
Worm   396 SIQSL--------QRNMEEKQRLQSLARTKHIATVDQVYVLADKYVMRDKL-RYDKIDINLLYQM 451

  Fly   478 --DLEDDNF------------------------SLNDYRFSFSFSQD----YEDIQVKAQRDMIL 512
              .|:.||.                        ||:|:.|:....:.    :|.:.:   ||::.
Worm   452 KSHLQHDNLNSFVGITIDKASHMYIIWNQCFRGSLHDHIFTKERQRGTATRFEGLFL---RDILK 513

  Fly   513 EVEHMPVNRVQTCKIRRPMHRIAKEDINEEYRFH---LESYYLFTTFRSWRMEWSFNKMRDLLMK 574
            .:|::..:.:               |.:.....|   |:|:        |.::.|...:..||:|
Worm   514 GLEYIHASAI---------------DFHGNLTLHNCMLDSH--------WIVKLSGFGVNRLLVK 555

  Fly   575 YSLGMMVFA-GATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLASYKKLW--LRGRRLSPITQP 636
            :.....:|. ..|.:     :|||.:.|   |.           .:.||:|  ...|....:..|
Worm   556 WKTSGQIFTEDHTPV-----IKSEELHY---FD-----------PAMKKIWKNYADRNERALITP 601

  Fly   637 TF----FLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCD-----IARLELEII-- 690
            .|    .:..:.:...::|.|..||.      .||.......::|...|     .:|..|.||
Worm   602 QFGKKCDMYSFGVILHEIILKKKFVE------QLFDSPREEDDSVLIDDENDAIASRFPLPIIIP 660

  Fly   691 -NSELHNLRPQML--CFMPWGVTYAVVIVLSLMLVIIGIPLIIKLGVGLAILGSHVITVHAYYGF 752
             ..|:||...:||  ||  ..|...:.:...:      |..::|:...|..|....:|.:.
Worm   661 EGIEMHNDLIKMLENCF--GSVRPDIALARKI------IDTVLKMSGSLVDLMIKNLTAYT---- 713

  Fly   753 AFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEKKHELTKVKTRTIK 817
                                            :| ||..:|         .:..||.|.:.:..:
Worm   714 --------------------------------QG-LNETVK---------NRTAELEKEQEKGDQ 736

  Fly   818 IIMANILPTHVAEVFKVRRRSDQLYYEN----FSQVAVMFATIENYEADKSGLRALHEMICYFDE 878
            ::| .:||..||...|.....|...|||    :|.: |.|.::.:.......:..|..|...||
Worm   737 LLM-ELLPKSVANDLKNGIAVDPKVYENATILYSDI-VGFTSLCSQSQPMEVVTLLSGMYQRFD- 798

  Fly   879 LLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDE 943
            |:::.|..||:|.|   |..|..|.||.|
Worm   799 LIISQQGGYKMETI---GDAYCVAAGLPV------------------------------------ 824

  Fly   944 IMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMA 1008
            :|.|| |.         .:|.::.....:.|.........|.|.        :.:.|...|||.|
Worm   825 VMEKD-HV---------KSICMIALLQRDCLHHFEIPHRPGTFL--------NCRWGFNSGPVFA 871

  Fly  1009 GVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDF--NIRCTYRGMTFVKGVGQV 1071
            ||:|...|.|..:|..|.:||:|.|:||.|.|.:|.::..:|.:.  ...|:.||...::|:|::
Worm   872 GVIGQKAPRYACFGEAVILASKMESSGVEDRIQMTLASQQLLEENFPQFVCSNRGGRTIEGIGRI 936

  Fly  1072 PTYLVD 1077
            .||.::
Worm   937 LTYWLE 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	17/73 (23%)
		CYCc	812..1051	CDD:214485	58/242 (24%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	59/240 (25%)
daf-11	NP_505960.3	Periplasmic_Binding_Protein_Type_1	<33..295	CDD:299141
		PKc_like	447..695	CDD:304357	54/306 (18%)
		HNOBA	<714..750	CDD:285003	12/46 (26%)
		CYCc	729..922	CDD:214485	60/252 (24%)
		Guanylate_cyc	756..943	CDD:278633	60/246 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900