Protein Alignment CG32301 and acy-4

DIOPT Version :10

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_504486.4
• Gene: acy-4 / 178949
• WormBaseID: WBGene00000071
• Length: 1013
• Species: Caenorhabditis elegans
• Alignment Length: 1134
• Identity: 284/1134 - (25%)
• Similarity: 495/1134 - (43%)
• Gaps: 223/1134 - (19%)

  Fly     7 KNVVDYRSLGNMPG---YEWKLLRY-----KCRELRLEGVYHRHCHLVSVALVTQLIIVIEILML 63
            ||.::..||..:..   :.|:.|||     |.:...|...|....:  |..:....:|::.|.:.
 Worm    45 KNRMECPSLDEILSFYHFPWEKLRYRKNSQKKKRSTLYSFYFEQVN--SGRIQFSFVILLSICIS 107

  Fly    64 IHVILLFSVVKNIDFLTVLPYFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAM-DLI 127
            ......|..    ::|..| ...::.|..|||........| ...||.::||::....|:| ..:
 Worm   108 EAAFSAFGA----EWLKSL-ILCILTLVISILSFFHAKRTE-LVCIASIISCVIISACTSMRTSV 166

  Fly   128 LPICYFRPFSLVP-SYDHVVIVLIYLMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDKV 191
            ..:..|..:||:| |:..::.....|.|.:||:.....|.:|..:.|.....:.|::.:.:|  |
 Worm   167 TYLLIFSTYSLLPMSFMLMIFSTFALTFLVAFIGVLMDYNVGFDIILTRVMMVILVNVVGSL--V 229

  Fly   192 WELTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLA 256
            :..|.             |:.|...:..|..:.||       ::....|..::.:|.:::|..:|
 Worm   230 YYPTE-------------FVQRKTFHETRKCVQSR-------MLLDKEMHRQEKILLAVLPKNIA 274

  Fly   257 RSL-QDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHEL 320
            ..: :|...:|.|.      .|.|   :::..:.::|||.||:..||.|.:.....|||.:|:||
 Worm   275 FEVKKDMQETHEER------MFHK---IYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNEL 330

  Fly   321 FVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLR 385
            |..||..|:.::..|||.|||.|.||.|:|.|...||...|....||||..|.|.:.....:::|
 Worm   331 FARFDKVASIHQCMRIKILGDCYYCVCGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMR 395

  Fly   386 IGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTA 450
            :|:|:|:...|::||.|||||:||.||.:.|::||.||.|.|||:..|...|...|:.|||...:
 Worm   396 VGIHTGKAHCGVLGLKKWQFDVWSNDVTLANQMESGGLAGRVHITDATRSYLKGAYILEEGNGGS 460

  Fly   451 KLDPLLQRSNLSTYLIRSRLPNFEDTDDLEDDNFSLNDYRFSFSFSQDYEDIQVKAQRDM----- 510
            : ...|::..:.|:|:..|.|::::......::..:..::.:...|:. |.:...:.|..
 Worm   461 R-SKFLEKEKIKTWLVVDRSPDYDNICQEATNHPVMVPWKSTRGISKQ-ERLTGMSTRTRGASTR 523

  Fly   511 -ILEVEHMPVNRVQTCKIRRPMHRIAKEDINEEYRFHLESYYLFTTFRSWRMEWSFNKMRDLLMK 574
             .|..|.:.|..|.: .:|:.:..|.:|:..   ..|.:::.|  .::..|:|..|.:::...:.
 Worm   524 NGLSEEEVLVENVDS-HLRQGIQAIHQENWK---TMHCKNWSL--KYKQVRVENKFVRLKYKDIP 582

  Fly   575 YSLGMMVFAGATIIAMDLLVKSEAMD---YTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQP 636
            :.:.:.|    .|:|:.:.:|...|:   ::.:..:|:::...::
 Worm   583 FQVTLYV----AIVAICIGIKFGLMNLVSFSFVPQMFIVLTSVMI-------------------- 623

  Fly   637 TFFLSRWFIKASDLIEKSV---FVRIPLAIMVLFLLYVMSSETVFSCDIARL-------ELEIIN 691
             |.|:|..||.:.|:...:   |:.:.:.|::|..:|    |:.|:||:.:.       ..||..
 Worm   624 -FILTRALIKHARLVSLVIGVLFILLSIQIVILMGMY----ESKFTCDVEKCFKNNYTDFFEIFE 683

  Fly   692 SELHNLRPQMLCFMPWGVTYAVVIVLSLMLVIIGIPLIIKLGVGLAILGSHVITVHAYYGFAFER 756
                      :|      |.|..::||:..:...:..:|.......::.:.:|.::.|....
 Worm   684 ----------IC------TLATCVILSVDFMTKLLMSMIYFSSFTVLITAKLIRINQYEALL--- 729

  Fly   757 SQTTNIGVTSSLAHSWYMVAFFIVVVVREGYL----NYILKASYF-MSMCFEKKHELTKVKTRTI 816
            |...|..|.|.|      ....:|...|...|    ::|.|.... ..:..::|||..
 Worm   730 STYANFCVLSCL------TLLLVVFSTRRSELISRYDFIWKLQALDEQLQMKRKHEQN------- 781

  Fly   817 KIIMANILPTHVAEVFKVRRRS-DQLYYENFSQVAVMFATIENY-----EADKSG-----LRALH 870
            :.::.||||:|||:.|.....| .:||:|:.....:||||:..:     |.|.:.     ||.|:
 Worm   782 RSVLENILPSHVAKHFVEDATSVSKLYHESRDNACIMFATLTEFDKFYIECDGNNEGVECLRLLN 846

  Fly   871 EMICYFDELL---VNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSG 932
            |:|..||::|   ::.:.:.||||||.:..||:.|.||               ..||..
 Worm   847 EIISDFDQILDQILDREEFKKIEKIKTISTTYMVASGL---------------AGRECG------ 890

  Fly   933 SVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILR--DIRSKGIFFEKDSKLTG 995
                                      |::.:..:..||..||..|.  :|.|...|
 Worm   891 --------------------------DNSHVEAIALFARELLVKLESTNIHSFNNF--------- 920

  Fly   996 SLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLR--DFNIRCT 1058
            :|:|||..|||:|||:|..||||||||::||:||||.|.||...|.|||...::|.  .:|..|
 Worm   921 NLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILEPLGYNFEC- 984

  Fly  1059 YRGMTFVKGVGQVPTYLV----DLDENLH 1083
             ||...|||.|.:.|:.:    |.|..|:
 Worm   985 -RGQINVKGKGMMETFFLLPPEDFDCQLY 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	113/396 (29%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	66/155 (43%)
		AcyC	681..1076	CDD:441717	114/424 (27%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	81/251 (32%)
acy-4	NP_504486.4	AcyC	93..455	CDD:441717	113/398 (28%)
		Guanylate_cyc	293..448	CDD:425528	65/154 (42%)
		Guanylate_cyc	807..1003	CDD:425528	81/253 (32%)