DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and acy-1

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_497970.1	Gene:	acy-1 / 175622	WormBaseID:	WBGene00000068	Length:	1253	Species:	Caenorhabditis elegans

Alignment Length:	1229	Identity:	275/1229 - (22%)
Similarity:	472/1229 - (38%)	Gaps:	396/1229 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 CLMALLLTAMD----LILPICYFRPFSLVPSYDHVVIVLIYLMFPIAFVKNGRAYFLGLAVSLFY 175
            ||:.||:.:.:    .:.|:.     ||..|:.  |::|||.:.|:..       :|.:.:.:.|
Worm   134 CLVTLLIFSAENQAAFMTPVA-----SLATSFQ--VVLLIYTVIPLPL-------YLCILIGIIY 184

  Fly   176 FGYMALIDKISTLDKV-WELTAY------------GAYLFFLNMLCMFLSRFQEYNMRSG--ILS 225
                :::.:|...:|: .|...|            |.:||.|..:     |.::..::.|  :|:
Worm   185 ----SILFEILNKNKIGLEEAGYIKLVLHAGVHLLGVHLFILTQV-----RQRKTFLKVGQSMLA 240

  Fly   226 RYQVVYQNLVFQMAMKEEKALLDSIIPVTLA-RSLQDAI-----------------ASHIEEDPS 272
            |     ::|..:...|:.  ::.|::|..:| ..|:||.                 |:.:::..:
Worm   241 R-----KDLELETQFKDH--MIQSVMPKKVADELLKDASELRRPSASNDSNCRTSNATQVDQPLA 298

  Fly   273 NLMP-FTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRI 336
            .::| :.|.|...|.....||||.||:..||.:::.....:||.:|::||..||.........:|
Worm   299 KMVPEYRKFRPFTMNLMTNVSILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLEKI 363

  Fly   337 KFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLT 401
            ..|||.|.||.|.|.....||...|...||||...|:....|.:::::|:|:|:|:::.|::|..
Worm   364 STLGDCYYCVAGCPEPCDDHACRTVEMGLDMIVAIRQFDIDRGQEVNMRVGIHTGKVMCGMVGTK 428

  Fly   402 KWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPL----------L 456
            :::||::|.||.:.|.:||||:.|.||:|..|..||...|..|||.|..  .||          :
Worm   429 RFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIEEGPDYD--GPLRMQVQGTERRV 491

  Fly   457 QRSNLSTYLIRSRLPNFEDTDDLEDDNFSLNDYRFSFSFSQDYEDIQVKAQRDMILEVEH---MP 518
            :..::.|:.|:.|:     .|.:|::...:.:.. |....:..:...:|.:....|::.|   .|
Worm   492 KPESMKTFFIKGRI-----NDGVEEEVMQVQEVE-SLHSQKSSKKSTLKQKWAEKLKMNHTNSYP 550

  Fly   519 VN----------RVQTCKIRRPMHRIAKED----INEEYRFHLESYYLFTTFRSWRMEWSFN-KM 568
            :.          |::..:..|....:.||.    |.|:.|.......|.|.        :|| ..
Worm   551 MRAAAREGGGSLRIKLAERNRSTQLLPKESNSICIMEDNRKSASLQALATN--------NFNGSN 607

  Fly   569 RDLLMKYS----LGMM-----------VFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLA 618
            .|....||    .|.:           ...|:....:.|.::....|...:..|...|......|
Worm   608 TDTNNTYSERGVAGSVSKKSVAGSESNSIKGSRSSGLQLSLQDGNSDLNSVGGLDTAISHHHNAA 672

  Fly   619 SYKKLWLRG---RRLSPIT-------QPTFF-----LSRW----------------FIKAS---- 648
            |..:.....   :||:.:.       ...|:     |::|                |:.:|
Worm   673 SLTRFDTDNNFDQRLAMVIGQGEGGFDKGFWNHHDSLNKWTLRFNEKDVEEEYRAHFVDSSERYT 737

  Fly   649 -----------DLIEK------------------SVFVRIPLAIMVLFLLYVMSSETVFSCDIAR 684
                       ||:|:                  .||:    .|:|..|::|:|....
Worm   738 ASKKGHVERHKDLMEQGGEKDGITGSTVNKYRYSGVFI----DIIVATLIFVISGAVA------- 791

  Fly   685 LELEIINSELHNLRP---QMLCFMPWGVTYAVVIVLSLMLVIIGIPLI----------------- 729
                     :.::||   .::.:.|:...     :|.|.:|:||:||:
Worm   792 ---------IMSVRPFPLSLIAYFPFAAA-----ILILTIVLIGLPLLARKKSFQCANQWMPRHL 842

  Fly   730 -------IKLGVGLAILG------------------SHV--ITVHAYYGFA-------------- 753
                   :.:||.:.|:.                  |:|  :.:.|:..|:
Worm   843 IGLLLIFLPIGVAICIMPLCQSGDCANVILNYRLAFSYVTILAIFAHCNFSQLAAWPKTTAAVFI 907

  Fly   754 ------------------FERSQTTN----------------IGVTSSLAHS-----------WY 773
                              .|...|.|                |.:.|:.|.:           |.
Worm   908 GLLHIAGVFYCEFNLKHLVEEQDTCNVTAIMIPPIRKGLNYTIALNSTSARTLSQDFGSPLFIWE 972

  Fly   774 MVAFFIVVVVREGYLNYILKASYFMSMCFEKKHELTKVKTRTIKII-------MANILPTHVAEV 831
            ::...|:.:|...:|||..:.::.||...:.:   .:..|..::|:       :.|::|.|..|.
Worm   973 LLLDVILSIVLVAFLNYQFETAFRMSFFGDVQ---ARRDTERMQIVRDQADWLLNNVIPAHAVES 1034

  Fly   832 FKVRRRSDQLYYENFSQVAVMFATI--------ENYEADKSGLRALHEMICYFDELLVNYQSWYK 888
            .|    :|..|.||...|.|:||:|        ||:|..:..||.|:|:|..||||| :...:..
Worm  1035 LK----TDTKYSENHETVGVLFASITNWNDMYEENFEGGREFLRVLNEVIGDFDELL-DRPDFTH 1094

  Fly   889 IEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQ 953
            |||||.:|..|:||.||                |.|..|                   ..|||.:
Worm  1095 IEKIKTIGPAYMAASGL----------------NPERKK-------------------NMLHPKE 1124

  Fly   954 ATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHY 1018
                    .:..|.:|||.:..:|      .:|.|.........|:|:..|||.|||:|.:|.:|
Worm  1125 --------HLYQMVDFALAVQHVL------SVFNEDLLNFDFVCKLGLNIGPVTAGVIGTTKLYY 1175

  Fly  1019 DIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDFNIRCTYRGMTFVKGV-GQVPTYLV 1076
            ||||.|||:||||.||||.:.|.|::.|...|.| .....:|....|||: |.:.|||:
Worm  1176 DIWGDTVNIASRMYSTGVLNRIQVSQHTREYLLD-RYEFEFRDHIEVKGIDGGMDTYLL 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	57/155 (37%)
		CYCc	812..1051	CDD:214485	82/253 (32%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	83/243 (34%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686	22/106 (21%)
		CYCc	297..469	CDD:214485	60/171 (35%)
		Guanylate_cyc	317..503	CDD:278633	65/187 (35%)
		SDF	<773..982	CDD:294387	32/233 (14%)
		CYCc	1016..1215	CDD:214485	82/253 (32%)
		Guanylate_cyc	1041..1235	CDD:278633	84/244 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900