DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and LRRK2

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	855	Identity:	165/855 - (19%)
Similarity:	297/855 - (34%)	Gaps:	245/855 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KLLRYKCRELRLEGVYHRHCHLVSVA-------------LVTQLIIVIEILMLIHVILL---FSV 72
            |:|..|...|.:..:..:|.|...||             ..|.|.|:..::..|..::.   .|:
Human   434 KILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSL 498

  Fly    73 VKNIDFLTVLPYFAVMLLTPSILMPSREPNVEQYESIAILVSC----LMALLLTAMD-------- 125
            ...::.|..:.:|.|    |.:...|||.....::...:...|    :..|:|.|::
Human   499 PVQLEALRAILHFIV----PGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGI 559

  Fly   126 ------LILPICYF----RPFSLVPSYDHVVIVLIYLMFP------------IAFVKNGRAYFLG 168
                  :|..|.:|    ...||..:.|.|:..|  .|:|            |.::...:..|:|
Human   560 QKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTL--QMYPDDQEIQCLGLSLIGYLITKKNVFIG 622

  Fly   169 --------LAVSLFYFGYMALIDK--ISTLDKVWELTAYGAYLFFLNM--LCMFLSRFQEYNMRS 221
                    |..||:.|..:|.|..  ..|:..:.:|:|..:.|...:.  |.:|      :.|.|
Human   623 TGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIF------HQMSS 681

  Fly   222 GILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARS-------------LQDAIASHIEEDPSN 273
            .|:.:....:.||..:...|  .|:.|.:..|.|.|:             |..|.|:..:|..|.
Human   682 NIMEQKDQQFLNLCCKCFAK--VAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL 744

  Fly   274 LMPFTKTRHLFMEPHPE-VSIL------EADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHN 331
            :....:     .|..|: |.:|      |.|:.....::.....|.::::|... ::.|:|.|.
Human   745 ICQVCE-----KESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRR-LALDVANNS- 802

  Fly   332 RATRIKFLGDSYTCVTGI------PSY----FPTHANACVNQALDMIEISREVSKRRNKKIDLRI 386
                        .|:.|.      ||:    ||...:....|......::|.|. |...|..:..
Human   803 ------------ICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVI-RYQMKSAVEE 854

  Fly   387 GVHSG-------EILAGIIGLTKWQFDIWSKDVDI--------TNRLESSGLPGMVHISSRTLGL 436
            |..||       ::|:        :||.|:...|.        ::.|:|.|..|...:..::..:
Human   855 GTASGSDGNFSEDVLS--------KFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSI 911

  Fly   437 LDNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTDDLE--------DDNF--------- 484
            ....: |.:.. ..:..|.|||.:      .|..|.|:..|.|:        ||:.
Human   912 SVGEF-YRDAV-LQRCSPNLQRHS------NSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHM 968

  Fly   485 ----------SLNDYRFSFSFS-QDYEDIQVKAQRDMI-LEVEHMPVNRVQTCKIRRPMHRIAKE 537
                      |..:|..|...| .:..||...:|:..| :.:||:.         :..:|:.|..
Human   969 RHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLE---------KLELHQNALT 1024

  Fly   538 DINEEY------RFHLESY-YLFTTFRSWRMEWSFNKMRDLLMKYSLGMMVFAGATIIAMDLLVK 595
            ...::.      ..||:.: ..||:|.|:.::.|.....| :.:..:|..|....|:....|  |
Human  1025 SFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLD-VSRNDIGPSVVLDPTVKCPTL--K 1086

  Fly   596 SEAMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFF---------------LSRWFI 645
            ...:.|..|  .|:...|..::...::|.|.|.::|.|..|...               ||..|:
Human  1087 QFNLSYNQL--SFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFL 1149

  Fly   646 KASDLIEKSVFVRIPLAIMVLFLLYVMS----SETVFSC--------------DIARLELEIINS 692
            :|...:| |...|:.....:.||...|:    |:..|||              |::..:::.:..
Human  1150 EACPKVE-SFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 1213

  Fly   693 ELH----NLR 698
            ..|    |||
Human  1214 PAHWKSLNLR 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	34/187 (18%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969		111/584 (19%)
		LRR 1	983..1004		6/20 (30%)
		leucine-rich repeat	985..1012	CDD:275380	6/26 (23%)
		LRR	1012..>1286	CDD:227223	45/227 (20%)
		LRR 2	1012..1033		3/29 (10%)
		leucine-rich repeat	1013..1036	CDD:275380	2/31 (6%)
		LRR 3	1036..1057		6/20 (30%)
		leucine-rich repeat	1037..1084	CDD:275380	11/47 (23%)
		LRR 4	1059..1080		3/21 (14%)
		LRR 5	1084..1105		6/24 (25%)
		leucine-rich repeat	1085..1108	CDD:275380	6/26 (23%)
		LRR 6	1108..1129		6/20 (30%)
		leucine-rich repeat	1109..1130	CDD:275380	6/20 (30%)
		LRR 7	1130..1150		3/19 (16%)
		leucine-rich repeat	1131..1174	CDD:275380	9/43 (21%)
		LRR 8	1174..1196		5/21 (24%)
		leucine-rich repeat	1175..1197	CDD:275380	5/21 (24%)
		LRR 9	1197..1218		2/20 (10%)
		leucine-rich repeat	1198..1221	CDD:275380	2/22 (9%)
		LRR 10	1221..1241		3/3 (100%)
		leucine-rich repeat	1222..1246	CDD:275380	2/2 (100%)
		LRR 11	1246..1267
		leucine-rich repeat	1247..1269	CDD:275380
		LRR 12	1269..1291
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900