Protein Alignment CG32301 and Adcy6

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: XP_006520366.3
• Gene: Adcy6 / 11512
• MGIID: 87917
• Length: 1254
• Species: Mus musculus
• Alignment Length: 1189
• Identity: 295/1189 - (24%)
• Similarity: 503/1189 - (42%)
• Gaps: 299/1189 - (25%)

  Fly    31 RELRLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVV------KNIDFLTVLPYFAVML 89
            |..:||.:|.|:...::.:.:|.|:.|:.:||.  |:|.|...      ..:..||......|:|
Mouse   218 RSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMA--VLLTFHAAPAQPQPAYVALLTCASVLFVVL 280

  Fly    90 LTPSILMPSREPN--VEQYESIAILVSCLMALLLTAMDLILPICYFRPFSLVPSYD-HVVIVLIY 151
            :........|:.:  |..|..:.||.:..:...|.|          .|.|  ||.. ...:..:|
Mouse   281 MVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAA----------NPHS--PSAGLWCPVFFVY 333

  Fly   152 LMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDK-VWELTAYGAYLFFLNM---LCMFL- 211
            :.:.:..::...|...||.:|..   ::.|..::::.|. :|:.......||....   :|...
Mouse   334 ITYTLLPIRMRAAVLSGLGLSTL---HLILAWQLNSSDPFLWKQLGANVVLFLCTNAIGVCTHYP 395

  Fly   212 ------SRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEED 270
                  ..|||  .|..|.:|..:.::|       ::::.||.|::|..:|..:::.|.:..|:
Mouse   396 AEVSQRQAFQE--TRGYIQARLHLQHEN-------RQQERLLLSVLPQHVAMEMKEDINTKKED- 450

  Fly   271 PSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATR 335
                |.|.|   ::::.|..||||.||:..||.|.:.....:||..|:|||..||..|..|...|
Mouse   451 ----MMFHK---IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLR 508

  Fly   336 IKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGL 400
            ||.|||.|.||:|:|.....||:.||...:||||....|.:.....:::|:|:|||.:..|::||
Mouse   509 IKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGL 573

  Fly   401 TKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYL 465
            .|||||:||.||.:.|.:|:.|..|.:||:..||..|:..|..|.|.. .:.:..|:...:.|:|
Mouse   574 RKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRG-GERNAYLKEQCIETFL 637

  Fly   466 I------------------RSRLPNFE------------------------DTDDLEDDNFSLND 488
            |                  |:|..:.|                        ..||...||....|
Mouse   638 ILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGAQD 702

  Fly   489 YRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCKIRRPMHRIAKEDINEEYRFHLESYYLF 553
               :.:...:.::...:|       ::...:::::...:||.:....:||:.::|
Mouse   703 ---ALNPEDEVDEFLGRA-------IDARSIDQLRKDHVRRFLLTFQREDLEKKY---------- 747

  Fly   554 TTFRSWRMEWSFNKMRDLLMKYSLGMMVFAGATIIAMDLLVKSEAMDYTMLF-----SLFLLILL 613
                |.:::..|...      .:..::||  ..|..:.|||    ..|:.|.     ::|||:|:
Mouse   748 ----SRKVDPRFGAY------VACALLVF--CFICFIQLLV----FPYSTLILGIYAAIFLLLLV 796

  Fly   614 PLLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVF 678
            .:|:.:             :.....|..:...:.|..|.:|......:.|..:.|:::.:...:|
Mouse   797 TVLICA-------------VCSCGSFFPKALQRLSRNIVRSRVHSTAVGIFSVLLVFISAIANMF 848

  Fly   679 SC------------------DIARLELEIINSELHNLRP-----QMLCFMPWGVTYAV-VIVLSL 719
            :|                  |:....|:.:|..|....|     ...|..|   .|.| .::|||
Mouse   849 TCNHTPIRTCAARMLNLTPADVTACHLQQLNYSLGLDAPLCEGTAPTCSFP---EYFVGNVLLSL 910

  Fly   720 ----------------MLVIIGIP--LIIKLGVGLAILGSH--VITVHAYYGFA-----FERSQT 759
                            |..|:|..  :::.||...||..::  ::.||   |.|     |:....
Mouse   911 LASSVFLHISSIGKLAMTFILGFTYLVLLLLGPPAAIFDNYDLLLGVH---GLASSNETFDGLDC 972

  Fly   760 TNIGVTSSLAHSWYMVAFFIVVVVREGYLN-------------YILKASYFMSMCFEKKHELTKV 811
            ..:|..:..    ||....::|.....||:             :.|:|:       .:|.|:.::
Mouse   973 PAVGRVALK----YMTPVILLVFALALYLHAQQVESTARLDFLWKLQAT-------GEKEEMEEL 1026

  Fly   812 KTRTIKIIMANILPTHVAEVFKVR-RRSDQLYYENFSQVAVMFATIENY-------EADKSG--- 865
            :... :.::.||||..||..|..| ||:|:|||::...||||||:|.|:       ||:..|
Mouse  1027 QAYN-RRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVEC 1090

  Fly   866 LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQK 930
            ||.|:|:|..||| :::.:.:.::||||.:|.||:||.||:...|               |::.:
Mouse  1091 LRLLNEIIADFDE-IISEERFRQLEKIKTIGSTYMAASGLNASTY---------------DQVGR 1139

  Fly   931 SGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTG 995
            |                  |            |..:.::|:.|:..::.|       .:.|....
Mouse  1140 S------------------H------------ITALADYAMRLMEQMKHI-------NEHSFNNF 1167

  Fly   996 SLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVL--RDFNIRCT 1058
            .:|||:..|||:|||:|..||.|||||:|||::|||.||||.|.|.||.....||  :.:.:.|
Mouse  1168 QMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC- 1231

  Fly  1059 YRGMTFVKGVGQVPTYLVD 1077
             ||:..|||.|::.||.::
Mouse  1232 -RGVVKVKGKGEMTTYFLN 1249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	66/155 (43%)
		CYCc	812..1051	CDD:214485	86/251 (34%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	84/246 (34%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454	54/266 (20%)
		Guanylate_cyc	456..640	CDD:306677	73/184 (40%)
		DUF1053	668..754	CDD:368844	12/109 (11%)
		Guanylate_cyc	1056..1250	CDD:306677	84/249 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000