Protein Alignment CG32301 and ADCY9

DIOPT Version :10

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: XP_005255136.1
• Gene: ADCY9 / 115
• HGNCID: 240
• Length: 1372
• Species: Homo sapiens
• Alignment Length: 1324
• Identity: 311/1324 - (23%)
• Similarity: 494/1324 - (37%)
• Gaps: 436/1324 - (32%)

  Fly    38 VYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDFLTVLPYFAVMLLTP-------SIL 95
            :|.||....|:||               .:|:|:       ||:...|.|  |||       |.|
Human   167 LYARHYAWTSLAL---------------TLLVFA-------LTLAAQFQV--LTPVSGRGDSSNL 207

  Fly    96 MPSREPN---VEQYESIAILVSCLMALLLTAM--DLILPICYFRPFSLVPSYDHVVIVLIYLMFP 155
            ..:..|.   :.|..|.::.:..|. ||.|.|  .|.|.:|
Human   208 TATARPTDTCLSQVGSFSMCIEVLF-LLYTVMHLPLYLSLC------------------------ 247

  Fly   156 IAFVKNGRAYFLGLAVSLFY--FGY----MALIDKISTLDKVWELTAYGAYLFFLNMLCMFLSRF 214
                       ||:|.|:.:  |||    .|...........|||.:.|.....::.:.:.|...
Human   248 -----------LGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVM 301

  Fly   215 QEYNMRSGILSRYQVVY--QNLVFQMAMKEEKALLDSIIPVTLARSL--------QDAIASHIEE 269
            .:...||..|...|.:.  ::|..:.|:||.  ::.|::|..:|..|        ::::..|...
Human   302 SQVRSRSTFLKVGQSIMHGKDLEVEKALKER--MIHSVMPRIIADDLMKQGDEESENSVKRHATS 364

  Fly   270 DPSN-------------LMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELF 321
            .|.|             ..||.      |:...|||||.||:|.||.::.......||.:|::||
Human   365 SPKNRKKKSSIQKAPIAFRPFK------MQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLF 423

  Fly   322 VSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRI 386
            ..||......:..:|..|||.|.||.|.|.....||..|:...|.||:...:..:.:.:.:::|:
Human   424 GRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRV 488

  Fly   387 GVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAK 451
            |||:|.:|.||:|:.:::||:||.||::.|.:|..|:.|.||||..|...||:.|..|:|....:
Human   489 GVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIER 553

  Fly   452 LDPLL---QRSNLSTYLIRSR-------------LPNFEDTD--------------------DLE 480
            |...:   |...|.||||..:             |..||..|                    ||.
Human   554 LGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLA 618

  Fly   481 DDNFSLNDYR----FSFSFS----------------QDYEDIQVKAQRDMIL------------- 512
            ....:.::.:    ...:|:                ||......|.....:|
Human   619 QTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKVTSSWLLFLSVPLLAHPPKA 683

  Fly   513 ----------------EVEHMPVNRVQTCKIRRPMHR---------------------------- 533
                            :.|.:..::...|:|.:...|
Human   684 SGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFV 748

  Fly   534 -IAKED-INEEYRFHLESYYLFTTF------RSWRMEW----------------SFNKMRDL--- 571
             :.||| :.::|.|..........|      ||:|..:                :|:.:.|:
Human   749 DVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLS 813

  Fly   572 -----------LMKYS--------LGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLL 617
                       .:||.        ..:.||:.|.:    |.|.|.|:...|:|      .|..::
Human   814 TTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALL----LEVLSLAVSIRMVF------FLEDVM 868

  Fly   618 ASYKKL--WLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIP-LAIM----------VLFLL 669
            |..|:|  |:.|           :|.|..|.|       :.|.:| ||:.          :.|.:
Human   869 ACTKRLLEWIAG-----------WLPRHCIGA-------ILVSLPALAVYSHVTSEYETNIHFPV 915

  Fly   670 YVMSS---ETVFSCDIARLELEIINSELHNLRPQMLCFMPWGVTYAVVIVLSLMLVIIGIPLIIK 731
            :..|:   ..|..|:..:|.                   .|        :.|.:..::|...::.
Human   916 FTGSAALIAVVHYCNFCQLS-------------------SW--------MRSSLATVVGAGPLLL 953

  Fly   732 LGVGLAILGSHVIT--VHAYYGFAFER-----SQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLN 789
            |.|.|. ..|.|:|  :.|...|:.||     |...::...:||.....::.||::::: ..:||
Human   954 LYVSLC-PDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLL-VWFLN 1016

  Fly   790 YILKASYFMSMCFEKKHELTKVKTRTIK----IIMANILPTHVAEVFKVRRRSDQLYYENFSQVA 850
            ...:.||.:....:.:.:|.:.|.::::    .::.||:|.||||..||    .|.|.:|.....
Human  1017 REFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKV----SQTYSKNHDSGG 1077

  Fly   851 VMFATI--------ENYEADKSGLRALHEMICYFDELL--VNYQSWYKIEKIKVMGWTYLAACGL 905
            |:||:|        ||||..|...|.|:|:|..|||||  .:|.|   |||||.:|.||:||.||
Human  1078 VIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSS---IEKIKTIGATYMAASGL 1139

  Fly   906 HVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFA 970
            :.....|.|                                   ||.:        .:.::.|||
Human  1140 NTAQAQDGS-----------------------------------HPQE--------HLQILFEFA 1161

  Fly   971 LNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTG 1035
            ..::|::.|..:..::|      ...|::|..|||:.|||:|.:|..|||||.|||:||||.:||
Human  1162 KEMMRVVDDFNNNMLWF------NFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTG 1220

  Fly  1036 VRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLV-DLDENLHFQQH----SPD----- 1090
            |...|.|:|.:..||........|||...|||.||:.|||. ...::....||    |||
Human  1221 VECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQV 1285

  Fly  1091 --------NDSHKGSIVSVHWLDE 1106
                    .|.....:.||.::|:
Human  1286 DGSIGRSPTDEIANLVPSVQYVDK 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	112/434 (26%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	58/155 (37%)
		AcyC	681..1076	CDD:441717	119/415 (29%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	84/244 (34%)
ADCY9	XP_005255136.1	AcyC	167..576	CDD:441717	127/476 (27%)
		Guanylate_cyc	385..573	CDD:425528	70/193 (36%)
		Guanylate_cyc	1069..1260	CDD:425528	83/242 (34%)