DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32301 and ADCY9

DIOPT Version :9

Sequence 1:NP_728724.2 Gene:CG32301 / 38285 FlyBaseID:FBgn0052301 Length:1111 Species:Drosophila melanogaster
Sequence 2:XP_005255136.1 Gene:ADCY9 / 115 HGNCID:240 Length:1372 Species:Homo sapiens


Alignment Length:1324 Identity:311/1324 - (23%)
Similarity:494/1324 - (37%) Gaps:436/1324 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 VYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDFLTVLPYFAVMLLTP-------SIL 95
            :|.||....|:||               .:|:|:       ||:...|.|  |||       |.|
Human   167 LYARHYAWTSLAL---------------TLLVFA-------LTLAAQFQV--LTPVSGRGDSSNL 207

  Fly    96 MPSREPN---VEQYESIAILVSCLMALLLTAM--DLILPICYFRPFSLVPSYDHVVIVLIYLMFP 155
            ..:..|.   :.|..|.::.:..|. ||.|.|  .|.|.:|                        
Human   208 TATARPTDTCLSQVGSFSMCIEVLF-LLYTVMHLPLYLSLC------------------------ 247

  Fly   156 IAFVKNGRAYFLGLAVSLFY--FGY----MALIDKISTLDKVWELTAYGAYLFFLNMLCMFLSRF 214
                       ||:|.|:.:  |||    .|...........|||.:.|.....::.:.:.|...
Human   248 -----------LGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVM 301

  Fly   215 QEYNMRSGILSRYQVVY--QNLVFQMAMKEEKALLDSIIPVTLARSL--------QDAIASHIEE 269
            .:...||..|...|.:.  ::|..:.|:||.  ::.|::|..:|..|        ::::..|...
Human   302 SQVRSRSTFLKVGQSIMHGKDLEVEKALKER--MIHSVMPRIIADDLMKQGDEESENSVKRHATS 364

  Fly   270 DPSN-------------LMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELF 321
            .|.|             ..||.      |:...|||||.||:|.||.::.......||.:|::||
Human   365 SPKNRKKKSSIQKAPIAFRPFK------MQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLF 423

  Fly   322 VSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRI 386
            ..||......:..:|..|||.|.||.|.|.....||..|:...|.||:...:..:.:.:.:::|:
Human   424 GRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRV 488

  Fly   387 GVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAK 451
            |||:|.:|.||:|:.:::||:||.||::.|.:|..|:.|.||||..|...||:.|..|:|....:
Human   489 GVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIER 553

  Fly   452 LDPLL---QRSNLSTYLIRSR-------------LPNFEDTD--------------------DLE 480
            |...:   |...|.||||..:             |..||..|                    ||.
Human   554 LGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLA 618

  Fly   481 DDNFSLNDYR----FSFSFS----------------QDYEDIQVKAQRDMIL------------- 512
            ....:.::.:    ...:|:                ||......|.....:|             
Human   619 QTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKVTSSWLLFLSVPLLAHPPKA 683

  Fly   513 ----------------EVEHMPVNRVQTCKIRRPMHR---------------------------- 533
                            :.|.:..::...|:|.:...|                            
Human   684 SGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFV 748

  Fly   534 -IAKED-INEEYRFHLESYYLFTTF------RSWRMEW----------------SFNKMRDL--- 571
             :.||| :.::|.|..........|      ||:|..:                :|:.:.|:   
Human   749 DVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLS 813

  Fly   572 -----------LMKYS--------LGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLL 617
                       .:||.        ..:.||:.|.:    |.|.|.|:...|:|      .|..::
Human   814 TTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALL----LEVLSLAVSIRMVF------FLEDVM 868

  Fly   618 ASYKKL--WLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIP-LAIM----------VLFLL 669
            |..|:|  |:.|           :|.|..|.|       :.|.:| ||:.          :.|.:
Human   869 ACTKRLLEWIAG-----------WLPRHCIGA-------ILVSLPALAVYSHVTSEYETNIHFPV 915

  Fly   670 YVMSS---ETVFSCDIARLELEIINSELHNLRPQMLCFMPWGVTYAVVIVLSLMLVIIGIPLIIK 731
            :..|:   ..|..|:..:|.                   .|        :.|.:..::|...::.
Human   916 FTGSAALIAVVHYCNFCQLS-------------------SW--------MRSSLATVVGAGPLLL 953

  Fly   732 LGVGLAILGSHVIT--VHAYYGFAFER-----SQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLN 789
            |.|.|. ..|.|:|  :.|...|:.||     |...::...:||.....::.||::::: ..:||
Human   954 LYVSLC-PDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLL-VWFLN 1016

  Fly   790 YILKASYFMSMCFEKKHELTKVKTRTIK----IIMANILPTHVAEVFKVRRRSDQLYYENFSQVA 850
            ...:.||.:....:.:.:|.:.|.::::    .::.||:|.||||..||    .|.|.:|.....
Human  1017 REFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKV----SQTYSKNHDSGG 1077

  Fly   851 VMFATI--------ENYEADKSGLRALHEMICYFDELL--VNYQSWYKIEKIKVMGWTYLAACGL 905
            |:||:|        ||||..|...|.|:|:|..|||||  .:|.|   |||||.:|.||:||.||
Human  1078 VIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSS---IEKIKTIGATYMAASGL 1139

  Fly   906 HVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFA 970
            :.....|.|                                   ||.:        .:.::.|||
Human  1140 NTAQAQDGS-----------------------------------HPQE--------HLQILFEFA 1161

  Fly   971 LNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTG 1035
            ..::|::.|..:..::|      ...|::|..|||:.|||:|.:|..|||||.|||:||||.:||
Human  1162 KEMMRVVDDFNNNMLWF------NFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTG 1220

  Fly  1036 VRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLV-DLDENLHFQQH----SPD----- 1090
            |...|.|:|.:..||........|||...|||.||:.|||. ...::....||    |||     
Human  1221 VECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQV 1285

  Fly  1091 --------NDSHKGSIVSVHWLDE 1106
                    .|.....:.||.::|:
Human  1286 DGSIGRSPTDEIANLVPSVQYVDK 1309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32301NP_728724.2 Nucleotidyl_cyc_III 283..439 CDD:299850 58/155 (37%)
CYCc 812..1051 CDD:214485 84/252 (33%)
Nucleotidyl_cyc_III 841..1076 CDD:299850 84/244 (34%)
ADCY9XP_005255136.1 DUF2339 <118..>301 CDD:287113 41/193 (21%)
CYCc 326..544 CDD:214485 71/225 (32%)
Guanylate_cyc 385..573 CDD:278633 70/193 (36%)
CYCc 1043..1243 CDD:214485 84/255 (33%)
Guanylate_cyc 1069..1260 CDD:278633 83/242 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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