DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32301 and ADCY8

DIOPT Version :9

Sequence 1:NP_728724.2 Gene:CG32301 / 38285 FlyBaseID:FBgn0052301 Length:1111 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:1137 Identity:301/1137 - (26%)
Similarity:502/1137 - (44%) Gaps:192/1137 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 GYEWK-----LLRYKCRELRLEGVYHRHC---HLVSVALVTQLIIVIEILMLIHVILLFSV---- 72
            ||.::     .||...:...||.:|.|:.   ...|..::..|.::.::.:|:..:.|.|.    
Human   146 GYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDP 210

  Fly    73 VKNIDFLTVLPYFAVMLLTPSILMPSREPNVE----QYESIAILVSCLMALLLTAMDLILPICYF 133
            :|.|    :|.:|..:.:....|:..|:....    ||..:...|:....:|...:...|     
Human   211 LKGI----LLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGL----- 266

  Fly   134 RPFSLVPSYDHVVIVLI--YLMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTLDKVWELTA 196
                |.....:|:..|.  |.|.|:...   .|...||..||.......:|.:::.: .:.::.|
Human   267 ----LGDGIGYVLFTLFATYSMLPLPLT---WAILAGLGTSLLQVILQVVIPRLAVI-SINQVVA 323

  Fly   197 YGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIP----VTLAR 257
            .......:|...:|:|...:...|...|...:.|...|..:...:.::.|:.|::|    :.:..
Human   324 QAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMIN 388

  Fly   258 SLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFV 322
            .:.:....|::.         :...:::..:..||||.||:..||.|:||:...:||.:|:|||.
Human   389 DMTNVEDEHLQH---------QFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFA 444

  Fly   323 SFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIG 387
            .||..|:.:...|||.|||.|.||:|:|.....||:.||...|.||:..|.|..|....:|:|||
Human   445 RFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIG 509

  Fly   388 VHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKL 452
            :|||.:|.|::||.|||||:||.||||.|:|||.|:||.:|||..||..|:..|..|||....: 
Human   510 IHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKER- 573

  Fly   453 DPLLQRSNLSTYLIRSRLPNFEDT-----DDLEDDNFSLNDYRFS------FSFSQDYEDIQVKA 506
            :..|::.|:.||||:..    ||:     :|:..::.|.:|.|.|      .|:|.:.....:..
Human   574 NEFLRKHNIETYLIKQP----EDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVG 634

  Fly   507 QRDMILEVEHMPVNRVQTCKIRRPMH-RIAKEDINEEY-------------RFHLESYYLFTTFR 557
            :::.:..:....:|.:.. .:.:.:| :...|:||:..             |.|::.:.|.  |:
Human   635 KQNTLAALTRNSINLLPN-HLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLM--FK 696

  Fly   558 SWRMEWSFNKMRDLLMKYSL--GMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLAS- 619
            ...:|..:::|||.:.|.:|  ..:|....|.| ..||..|..|..|:.||:.:::...|:|.: 
Human   697 DSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAI-QSLLPSSRVMPMTIQFSILIMLHSALVLITT 760

  Fly   620 ---YKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCD 681
               ||.|.|..|:.......|:......|.||              |::.||..:::   :..||
Human   761 AEDYKCLPLILRKTCCWINETYLARNVIIFAS--------------ILINFLGAILN---ILWCD 808

  Fly   682 IARLELEIINSELHNLRPQM------LCFMPWGVTYAVVIVLSLMLVIIGIPLIIKLGVGLAILG 740
            ..:      :..|.||....      :|..|....:..|:.:....|.:.:..::||.|.|.::.
Human   809 FDK------SIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIA 867

  Fly   741 SHVITVHAYYGFAFERSQTTNIGVTSSLAH---SWYMVAFFIVVVVREG-YLNYILKASYFMSMC 801
            .:.:.....|...|.|....|......|..   |..::|.|::.|...| .|.|..:..:...: 
Human   868 IYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRV- 931

  Fly   802 FEKKHELTKVK--TRTIKIIMANILPTHVAEVFKVR-RRSDQLYYENFSQVAVMFATIENY---- 859
             :.|.|:.::|  ....:.::.||||:|||..|..: |.:::||.:::..|.||||:|..:    
Human   932 -QAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFY 995

  Fly   860 ---EADKSG---LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVP 918
               |.:..|   ||.|:|:|..||||| ....:..|||||.:|.||:|..|              
Human   996 SQTEMNNQGVECLRLLNEIIADFDELL-GEDRFQDIEKIKTIGSTYMAVSG-------------- 1045

  Fly   919 ISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSK 983
                                          |.|.:....:....:..:.:|:|.|...:::|   
Human  1046 ------------------------------LSPEKQQCEDKWGHLCALADFSLALTESIQEI--- 1077

  Fly   984 GIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTAN 1048
                .|.|.....|:|||:||.|:|||:|..||.|||||.|||:||||.||||...|.|.|.|..
Human  1078 ----NKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYL 1138

  Fly  1049 VLRDFNIRCTYRGMTFVKGV----GQVPTYLV 1076
            :|:|......|||..:|||:    |::.||.:
Human  1139 ILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32301NP_728724.2 Nucleotidyl_cyc_III 283..439 CDD:299850 76/155 (49%)
CYCc 812..1051 CDD:214485 81/251 (32%)
Nucleotidyl_cyc_III 841..1076 CDD:299850 82/248 (33%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182 8/35 (23%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92
AC_N <161..400 CDD:292831 44/255 (17%)
CYCc 366..564 CDD:214485 80/206 (39%)
Guanylate_cyc 405..589 CDD:278633 86/184 (47%)
DUF1053 617..711 CDD:283888 15/96 (16%)
CYCc 944..1148 CDD:214485 82/255 (32%)
Guanylate_cyc 973..1172 CDD:278633 82/250 (33%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 30/62 (48%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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