DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and ADCY7

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	XP_011521137.1	Gene:	ADCY7 / 113	HGNCID:	238	Length:	1086	Species:	Homo sapiens

Alignment Length:	1173	Identity:	315/1173 - (26%)
Similarity:	504/1173 - (42%)	Gaps:	273/1173 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LVTQLIIVIEILMLIHVILLFS--------VVKNIDFLTVLPYFAVMLLTPSILMPSREPNVEQY 106
            |:..|::|.....:..:|:.||        .:..:.|| ||..||.:
Human    34 LLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFL-VLAVFAAL------------------ 79

  Fly   107 ESIAILVSCLMALLLTAMDLILPIC-----YFRPFSL----------VPSYDHVVIVLIYLMFPI 156
             |:.:.|.||:...|.|:.|:...|     |...|..          ||.:..:|.| :|.:.|
Human    80 -SVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFV-VYTLLP- 141

  Fly   157 AFVKNGRAYFLGLAVS----LFYFGYMALIDKISTLD-KVWELTAYGAYLFFLNMLCMFLS-RFQ 215
             |...| |..:| |||    |...|  :|:...:|.. :|.......|.:|    ||..|: .|.
Human   142 -FSMRG-AVAVG-AVSTASHLLVLG--SLMGGFTTPSVRVGLQLLANAVIF----LCGNLTGAFH 197

  Fly   216 EYNMRSGILSRYQVVYQNLVFQMAMK------EEKALLDSIIPVTLARSLQDAIASHIEE-DPSN 273
            ::.|:..  ||....|.....|:..|      :::.||.|::|..::..::.||...::| ....
Human   198 KHQMQDA--SRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRR 260

  Fly   274 LMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKF 338
            .||......|:::.|..||||.||:|.||.|.:.....:||.:|:|||..||..|..|...|||.
Human   261 CMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKI 325

  Fly   339 LGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKW 403
            |||.|.||:|:|...||||..||...|||.:..::|.:.....|::|:|:|||.:|.|:|||.||
Human   326 LGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKW 390

  Fly   404 QFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLI-- 466
            |:|:||.||.:.||:|::|:||.|||:..||..||..|..|:|....: ||.|:..|:.|||:
Human   391 QYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQR-DPYLKEMNIRTYLVID 454

  Fly   467 -RSR--------LPNFEDTDDLE-DDNFSLNDYRFSFSFSQDYEDIQVKAQRDMILEVE-HMPVN 520
             ||:        ||..:....|: ..:..:..|..|:..::.:..:.   .|:.:...| |:|..
Human   455 PRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLN---HRESVSSGETHVPNG 516

  Fly   521 RVQTCKIRR----------PMHRIAKEDINEEYRFHLESYYL----------FTTFRSWRMEWSF 565
            |......:|          |..|...:..::|....:|....          |.||.|..:|..|
Human   517 RRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGF 581

  Fly   566 NKMRDLL------MKYSLGMMVFAGATIIAMDLLVKSEAMDYTM-LFSLFLLILLPLLLASYKKL 623
            .:...|.      ..::...::|....::.:.|:.::.|:..:. |.:..|.::|.|..|:
Human   582 EREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFAT---- 642

  Fly   624 WLRGRRLSPI--TQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCDIARLE 686
              :..|..|.  |..|.         |:.:|....:|:.||::.:..|..          :|.:.
Human   643 --KFSRCCPARGTLCTI---------SERVETQPLLRLTLAVLTIGSLLT----------VAIIN 686

  Fly   687 LEIINSELHNL-------------RPQMLCF-MPWGVTYAVV--IVLSLMLVIIGIPLIIKLGVG 735
            |.::..::..|             :.:.||. :|:.....|:  |..|:.|.:...|.::.|.|.
Human   687 LPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVA 751

  Fly   736 LAILGSHVITVHAYYGFAFERSQ--------------TTNIGVTSSL-AHSW---------YMVA 776
            |..           |...|..|.              |...|.||.. :.||         |:|.
Human   752 LVA-----------YLVLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVL 805

  Fly   777 FFIVVVVREGYLNYILKASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVRRRSDQL 841
            |:|.::.....::|..:........|:|:||..:......::::.|:||.|||..|...:.::..
Human   806 FYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDW 870

  Fly   842 YYENFSQVAVMFATIENY-------EADKSG---LRALHEMICYFDELLVNYQSWYKIEKIKVMG 896
            |::::..|.||||::.::       :.:|.|   ||.|:|:|..|||||:. ..:..:||||.:|
Human   871 YHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLK-PKFSGVEKIKTIG 934

  Fly   897 WTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDN 961
            .||:||.||.|            ::..|:.:|::                :..|
Human   935 STYMAAAGLSV------------ASGHENQELER----------------QHAH----------- 960

  Fly   962 TILVMTEFALNLLRILRDIRSKGIFFEKDSKLTG---------SLKIGIAHGPVMAGVVGLSKPH 1017
             |.||.||::.|:                |||.|         .|::||.||||:|||:|..||.
Human   961 -IGVMVEFSIALM----------------SKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQ 1008

  Fly  1018 YDIWGHTVNMASRMTSTG------VRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLV 1076
            |||||:|||:||||.|||      |.....|||.|..:|:.....|..||:..|||.|::.||.|
Human  1009 YDIWGNTVNVASRMESTGELGKIQVSLPFQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFV 1073

  Fly  1077 DLD 1079
            ..|
Human  1074 CTD 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	74/155 (48%)
		CYCc	812..1051	CDD:214485	83/263 (32%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	86/259 (33%)
ADCY7	XP_011521137.1	AC_N	<73..249	CDD:292831	47/207 (23%)
		CYCc	224..429	CDD:214485	84/204 (41%)
		Guanylate_cyc	270..432	CDD:278633	76/161 (47%)
		DUF1053	485..592	CDD:283888	19/109 (17%)
		CYCc	848..1052	CDD:214485	84/260 (32%)
		Guanylate_cyc	871..1073	CDD:278633	86/258 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6637
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.060