Protein Alignment CG32301 and ADCY6

DIOPT Version :10

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_056085.1
• Gene: ADCY6 / 112
• HGNCID: 237
• Length: 1168
• Species: Homo sapiens
• Alignment Length: 1210
• Identity: 302/1210 - (24%)
• Similarity: 508/1210 - (41%)
• Gaps: 341/1210 - (28%)

  Fly    31 RELRLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDFLTVLPYFAVMLLTPSIL 95
            |..:||.:|.|:...::.:.:|.|:.|  :::|..|:|.|...
Human   132 RSAKLERLYQRYFFQMNQSSLTLLMAV--LVLLTAVLLAFHAA---------------------- 172

  Fly    96 MPSR-EPNVEQYESIAILVSCLMALLLTAMDLILPIC---YFRPFSL-VPSYDHVVI-VLIYLMF 154
             |:| :|      :...|::|..||.:.    ::.:|   .||..|: |.||  ||: :|..:..
Human   173 -PARPQP------AYVALLACAAALFVG----LMVVCNRHSFRQDSMWVVSY--VVLGILAAVQV 224

  Fly   155 PIAFVKNGRAYFLGLAVSLF--YFGYMALIDK----------ISTLDKV--WELTAYGAYLF--- 202
            ..|...:.|:...||...:|  |..|..|..:          :|||..:  |:|....|:|:
Human   225 GGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQL 289

  Fly   203 ---FLNMLCMFL--------------SRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSI 250
               .|..||..:              ..|||  .|..|.:|..:.::|       ::::.||.|:
Human   290 GANVLLFLCTNVIGICTHYPAEVSQRQAFQE--TRGYIQARLHLQHEN-------RQQERLLLSV 345

  Fly   251 IPVTLARSLQDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVA 315
            :|..:|..:::.|.:..|:     |.|.|   ::::.|..||||.||:..||.|.:.....:||.
Human   346 LPQHVAMEMKEDINTKKED-----MMFHK---IYIQKHDNVSILFADIEGFTSLASQCTAQELVM 402

  Fly   316 ILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNK 380
            .|:|||..||..|..|...|||.|||.|.||:|:|.....||:.||...:||||....|.:....
Human   403 TLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGV 467

  Fly   381 KIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEE 445
            .:::|:|:|||.:..|::||.|||||:||.||.:.|.:|:.|..|.:||:..||..|:..|..|.
Human   468 NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEP 532

  Fly   446 GTDTAKLDPLLQRSNLSTYLI------------------RSRLPNFE------------------ 474
            |.. .:.:..|:..::.|:||                  |:|..:.|
Human   533 GRG-GERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDS 596

  Fly   475 ------DTDDLEDDNFSLNDYRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCKIRRPMHR 533
                  ..||...||....|   :.:...:.::...:|       ::...:::::...:||.:..
Human   597 KAFRQMGIDDSSKDNRGTQD---ALNPEDEVDEFLSRA-------IDARSIDQLRKDHVRRFLLT 651

  Fly   534 IAKEDINEEYRFHLESYYLFTTFRSWRMEWSFNKMRDLLMKYSLGMMVFAGATIIAMDLLVKSEA 598
            ..:||:.::|              |.:::..|...      .:..::||.....|.: |:.....
Human   652 FQREDLEKKY--------------SRKVDPRFGAY------VACALLVFCFICFIQL-LIFPHST 695

  Fly   599 MDYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVR----- 658
            :...:..|:|||:|:.:|:.:                 .:.....|.||...:.:|: ||
Human   696 LMLGIYASIFLLLLITVLICA-----------------VYSCGSLFPKALQRLSRSI-VRSRAHS 742

  Fly   659 IPLAIMVLFLLYVMSSETVFSC------------------DIARLELEIINSEL----------- 694
            ..:.|..:.|::..:...:|:|                  ||....|:.:|..|
Human   743 TAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTM 807

  Fly   695 -------HNLRPQMLCFMPWGV--------TYAVVIVLS---LMLVIIGIPLIIKLGVGLAILGS 741
                   :.:...:|..:...|        ..|::.||.   |:|:::|.|..|.....| :||.
Human   808 PTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDL-LLGV 871

  Fly   742 HVITVHAYYGFAFERSQTTNIGVTSSLAHS---WYMVAFFIVVVVREGYLN-------------Y 790
            |        |.|  .|..|..|:....|..   .||....::|.....||:             :
Human   872 H--------GLA--SSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLW 926

  Fly   791 ILKASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVR-RRSDQLYYENFSQVAVMFA 854
            .|:|:       .:|.|:.:::... :.::.||||..||..|..| ||:|:|||::...||||||
Human   927 KLQAT-------GEKEEMEELQAYN-RRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFA 983

  Fly   855 TIENY-------EADKSG---LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDH 909
            :|.|:       ||:..|   ||.|:|:|..||| :::.:.:.::||||.:|.||:||.||:...
Human   984 SIANFSEFYVELEANNEGVECLRLLNEIIADFDE-IISEERFRQLEKIKTIGSTYMAASGLNAST 1047

  Fly   910 YTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLL 974
            |               |::.:|                  |            |..:.::|:.|:
Human  1048 Y---------------DQVGRS------------------H------------ITALADYAMRLM 1067

  Fly   975 RILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDG 1039
            ..::.|       .:.|.....:|||:..|||:|||:|..||.|||||:|||::|||.||||.|.
Human  1068 EQMKHI-------NEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDR 1125

  Fly  1040 IHVTESTANVL--RDFNIRCTYRGMTFVKGVGQVPTYLVD 1077
            |.||.....||  :.:.:.|  ||:..|||.|::.||.::
Human  1126 IQVTTDLYQVLAAKGYQLEC--RGVVKVKGKGEMTTYFLN 1163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	126/433 (29%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	66/155 (43%)
		AcyC	681..1076	CDD:441717	129/452 (29%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	84/246 (34%)
ADCY6	NP_056085.1	AC_N	<16..368	CDD:318454	62/286 (22%)
		Guanylate_cyc	370..554	CDD:425528	73/184 (40%)
		Adcy_cons_dom	582..669	CDD:461877	12/110 (11%)
		Guanylate_cyc	970..1164	CDD:425528	84/249 (34%)