DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and ADCY3

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	XP_011530791.1	Gene:	ADCY3 / 109	HGNCID:	234	Length:	1186	Species:	Homo sapiens

Alignment Length:	1214	Identity:	287/1214 - (23%)
Similarity:	500/1214 - (41%)	Gaps:	302/1214 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VKNIDFLTVLPYFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDLILPICYFRPFS 137
            |:|......||.|..:...|..|....:...::.....:||..:.|.|.....:::....|....
Human    40 VRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDK 104

  Fly   138 L----VPSYDHVVIVLIYL-----MFPIAFVKNGRAYFLGLAVSLFYFGYMAL--------IDKI 185
            |    |.....|:.:::::     :.|....:....|.|.|.::...|.|:.|        .|.:
Human   105 LASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTV 169

  Fly   186 STLDKVWELTAYGAYLFFLNM---------------------LCMFLSRFQEYNMRS-------- 221
            .     |::  :..:.||:.:                     |.:.:::.|:..::.
Human   170 G-----WQV--FFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREIL 227

  Fly   222 ------------GILSRYQV----------VYQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIA 264
                        ||:|.|..          ..|:|..:|.::|:....::::...|.:.:.|.:.
Human   228 ANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEML 292

  Fly   265 SHIEEDPS--NLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVSFD-L 326
            ..:::|.|  :...|..   ::|..|..||||.||:|.||.|::.....:||.:|:|||..|| |
Human   293 KDMKKDESQKDQQQFNT---MYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKL 354

  Fly   327 AANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGVHSG 391
            ||.::: .|||.|||.|.|:.|:|.|...||...:...|.|:|....|.::....:|:|:|||:|
Human   355 AAKYHQ-LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTG 418

  Fly   392 EILAGIIGLTKWQFDIWSKDVDITNRLESSGLPG----------------------MVHISSRTL 434
            .:|.|::|..:||:|:||.||.:.|::|:.|:||                      .||||..|:
Human   419 TVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRWERVHISQSTM 483

  Fly   435 GLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRLPNFEDTD---------------------- 477
            ..|...:..|.|...::.| .|:...:.||||.:..|..:.|.
Human   484 DCLKGEFDVEPGDGGSRCD-YLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSS 547

  Fly   478 ----DLEDDNFSLNDYRFSFSFSQDYEDIQVKAQRDMILEVEH---MPVNRVQTCKIRRPMHRIA 535
                :.::.|.|.:.   |.|.|:..|:...:.....:..:.|   :|.::........|..|:.
Human   548 PALIETKEPNGSAHS---SGSTSEKPEEQDAQLFPTTLSHLPHSRCLPGSQADNPSFPNPRRRLR 609

  Fly   536 KEDI--------NEEYRFH-------LE-----------SYYLFTTFRSWRME--WSFNKMRDLL 572
            .:|:        .:|:..:       ||           ::.|...|....||  :|..|.:...
Human   610 LQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSG 674

  Fly   573 MKYSLGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPT 637
            ..:|...:|.....::  ::|:....|...:.|.:..::||.|.:.|...::.|.     ..:..
Human   675 AAFSCSCVVLLCTALV--EILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRA-----FPKKL 732

  Fly   638 FFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSC-------DIARLELEIINSELH 695
            ...|.|       |:::.:.|...|::.:|:|.:.:...:.||       ..|...:|...|.|.
Human   733 VAFSTW-------IDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLE 790

  Fly   696 NLRPQMLCFMPWGVTYAVVIVLSLMLVIIGIPLIIKLGVGLAILGSHVITVHAY--------YG- 751
            |         |....|..|:.|...::::.:..::||.:.|.:.|: |.|::.|        |.
Human   791 N---------PKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGA-VATINLYAWRPVFDEYDH 845

  Fly   752 ----------FAFERSQTTNIGVTSS-----LAHSWYMVAFFIVVVVREGYLNYILKASYFMSMC 801
                      .|.|:.|..|.|:..:     |..|.|.:...:.:::    |::     |:.|..
Human   846 KRFREHDLPMVALEQMQGFNPGLNGTDSRLPLVPSKYSMTVMVFLMM----LSF-----YYFSRH 901

  Fly   802 FEK--------KHELTKVKTRTIKI------IMANILPTHVAEVF-KVRRRSDQLYYENFSQVAV 851
            .||        |.|:...|.|..::      ::.|:||.|||..| ..::|.::||.:.:.::.|
Human   902 VEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGV 966

  Fly   852 MFATIENY------EADKSG----LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLH 906
            |||::.|:      |:..:|    ||.|:|:|..||.||.| ..:..|.|||.:|.||:||.|:.
Human   967 MFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDN-PKFRVITKIKTIGSTYMAASGVT 1030

  Fly   907 VDHYTDFSVSVPISTN--RESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEF 969
            .|          ::||  ..|:|..||...|:.       .:.||                 .:|
Human  1031 PD----------VNTNGFASSNKEDKSERERWQ-------HLADL-----------------ADF 1061

  Fly   970 ALNLLRILRDIRSKGI--FFEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMT 1032
            ||.:...|.:|.::..  |.         |:||:..|.|:|||:|..||||||||:|||:||||.
Human  1062 ALAMKDTLTNINNQSFNNFM---------LRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRME 1117

  Fly  1033 STGVRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLV 1076
            ||||...|.|.|.|..:||::..|...||..||||.|::.|:.:
Human  1118 STGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFL 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	67/178 (38%)
		CYCc	812..1051	CDD:214485	87/259 (34%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	88/248 (35%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831	38/265 (14%)
		CYCc	273..490	CDD:214485	72/220 (33%)
		Guanylate_cyc	310..516	CDD:278633	75/207 (36%)
		CYCc	925..1143	CDD:214485	88/261 (34%)
		Guanylate_cyc	956..1163	CDD:278633	88/250 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900