DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32301 and ADCY2

DIOPT Version :9

Sequence 1:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster
Sequence 2:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens

Alignment Length:	1182	Identity:	323/1182 - (27%)
Similarity:	520/1182 - (43%)	Gaps:	243/1182 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EWKLLRYKCRELRLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVI--LLFSVVKNIDFLTVLP- 83
            :|....|.|...:         |.:.|.|:  ||::...|.|:.|.  |...|..::.||..:|
Human    31 DWLYESYYCMSQQ---------HPLIVFLL--LIVMGSCLALLAVFFALGLEVEDHVAFLITVPT 84

  Fly    84 ----YFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDLILPIC------YFRPF-S 137
                :||:.:|                    :.:..:...||....|::.||      .|..| .
Human    85 ALAIFFAIFIL--------------------VCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGG 129

  Fly   138 LVPSYDHV-----VIVLIYLMFP-------IAFVKNGRAYFLGLAVSLFYF--GYMALIDKISTL 188
            .|..:|.|     :|.::|.|.|       ||.|....::.:.|:|.|...  |...|
Human   130 TVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHL------- 187

  Fly   189 DKVWELTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQ----VVYQNLVFQMAMKEEKALLDS 249
              ||::.| ...:|....|.   ..:.::.|...:...||    .:...:..:...::::.||.|
Human   188 --VWQILA-NVIIFICGNLA---GAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLS 246

  Fly   250 IIPVTLARSLQDAIASHIEEDPSNLMPFTKTRH-LFMEPHPEVSILEADMVDFTGLTTTMEVSDL 313
            ::|..:|..::..|...::...:..|..|...| |:::.|..||||.||:|.||.|.:.....:|
Human   247 LLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGEL 311

  Fly   314 VAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRR 378
            |.:|:|||..||..|..|...|||.|||.|.||:|:|...|.||..||...|||.|..::|....
Human   312 VHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDAT 376

  Fly   379 NKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVY 443
            ...|::|:|||||.:|.|:|||.|||:|:||.||.:.|.:|:.|:||.|||||.||..|:..|..
Human   377 GVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKV 441

  Fly   444 EEGTDTAKLDPLLQRSNLSTYLI-------RSRLPNFEDTDDLED----DNFSLNDYRFSFSFSQ 497
            |||....: ||.|::..:.||.:       ||....|.....|:.    .:..:..|..|:..::
Human   442 EEGDGDIR-DPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAK 505

  Fly   498 DYEDIQVKAQRDMI------LEVEHMPV------NRVQTCKIRRPMHRIAKEDINEE-------- 542
            .:..:.   .||.:      :....:|:      ||....|.::   :..:|::||.
Human   506 PFAHLH---HRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQK---KRFEEELNERMIQAIDGI 564

  Fly   543 -------------------YRFHLESYYLFTTFRSWRMEWSFNKMRDLLMKY--SLGMMVFAGAT 586
                               |...||..|..|...::              ||  :...::|....
Human   565 NAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAF--------------KYYVTCACLIFFCIF 615

  Fly   587 IIAMDLLVKSEAMDYTMLFSLFLLILLPLLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLI 651
            |:.:.:|.|:..:..: ..:.|||:...|.:....:|....::.||       |..|.:|:|.:|
Human   616 IVQILVLPKTSVLGIS-FGAAFLLLAFILFVCFAGQLLQCSKKASP-------LLMWLLKSSGII 672

  Fly   652 EKSVFVRIPLAIMVLFLLYVM----------SSETV-FSCDIARLELEIINSELHNLRPQMLCFM 705
            ....:.||.|.|:...::.:|          |.||: .:.:.........|:::..||.|.|.|:
Human   673 ANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFL 737

  Fly   706 PWGVTYAVVIVLSLMLVIIGIPLIIKLGVGL-AILGSHVITVHA-------YYGFAFERSQTTNI 762
            |:.: |:.::.|....|.:.:...:|:.:.: |::|.:.|.:|.       |....|||.
Human   738 PYFI-YSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERP----- 796

  Fly   763 GVTSSL--AHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEKKHELTKVKTRTIKIIMANILP 825
            |:...|  ..|..:..|||.::|......|..:..:.....|:|:.|..:......::::.|:||
Human   797 GIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLP 861

  Fly   826 THVAEVFKVRR-RSDQLYYENFSQVAVMFATIENY-------EADKSG---LRALHEMICYFDEL 879
            .||||.|..|. ::::||::::..|.||||:|.::       :.:|.|   ||.|:|:|..||:|
Human   862 AHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDL 926

  Fly   880 LVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEI 944
            | :...:..:||||.:|.||:||.||.         :||...:.:..:.|.
Human   927 L-SKPKFSGVEKIKTIGSTYMAATGLS---------AVPSQEHSQEPERQY-------------- 967

  Fly   945 MIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEKDSKLTGSLKIGIAHGPVMAG 1009
                :|            |..|.|||..|:..| |..:|..|  .|.|    |::||.||||:||
Human   968 ----MH------------IGTMVEFAFALVGKL-DAINKHSF--NDFK----LRVGINHGPVIAG 1009

  Fly  1010 VVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTY 1074
            |:|..||.|||||:|||:||||.||||.|.|.|||.|:.||:.....||.||:..|||.|.:.||
Human  1010 VIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTY 1074

  Fly  1075 LVDLDENLHFQQ 1086
            .|:.:.:....|
Human  1075 FVNTEMSRSLSQ 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	76/155 (49%)
		CYCc	812..1051	CDD:214485	91/249 (37%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	93/244 (38%)
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831	53/270 (20%)
		CYCc	236..439	CDD:214485	85/202 (42%)
		Guanylate_cyc	281..465	CDD:278633	85/184 (46%)
		DUF1053	495..599	CDD:283888	16/109 (15%)
		CYCc	848..1056	CDD:214485	92/254 (36%)
		Guanylate_cyc	878..1077	CDD:278633	93/245 (38%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922		7/16 (44%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.970