Protein Alignment CG32301 and ADCY1

DIOPT Version :10

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: NP_066939.1
• Gene: ADCY1 / 107
• HGNCID: 232
• Length: 1119
• Species: Homo sapiens
• Alignment Length: 1129
• Identity: 298/1129 - (26%)
• Similarity: 483/1129 - (42%)
• Gaps: 285/1129 - (25%)

  Fly    64 IHVILLFS--VVKNIDFLTVLPYFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDL 126
            :|.:|..:  ||.|:..|.|                   |.::|...:|:|.|...|||
Human    97 VHCVLFLALLVVTNVRSLQV-------------------PQLQQVGQLALLFSLTFALL------ 136

  Fly   127 ILPICYFRPFSL-VPSYDHV---------------VIVLIYLMFPIAFVKNGRAYFLGLAVSLFY 175
               .|   ||:| .|:....               ::::.::.:.:..|::..|...||.|:..:
Human   137 ---CC---PFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASH 195

  Fly   176 FGYMALIDKISTLDKVWELTAYGAYLFF-LNMLCMFLSRFQEYNMRSGILSRYQVVYQNLVFQMA 239
            ....|.:.. :...::|......|.||. :||..:|:....|.:.|...|.....:...|..:..
Human   196 LLVTATLVP-AKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDE 259

  Fly   240 MKEEKALLDSIIPVTLARSLQDAIASHIEEDPSNLMPFTKTRH-LFMEPHPEVSILEADMVDFTG 303
            .::::.||.|::|..:|..:::..          |.|..:..| ::::.|..||||.||:|.|||
Human   260 NEKQERLLMSLLPRNVAMEMKEDF----------LKPPERIFHKIYIQRHDNVSILFADIVGFTG 314

  Fly   304 LTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMI 368
            |.:.....:||.:|:|||..||..|..|...|||.|||.|.||:|:......||:.||...||||
Human   315 LASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMI 379

  Fly   369 EISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRT 433
            :....|::.....:::|:|:|:|.:|.|::||.|||:|:||.||.:.|.:|::||||.|||:..|
Human   380 DTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTT 444

  Fly   434 LGLLDNHYVYEEGTDTAKLDPLLQRSNLSTYLI-----RSRLPNFEDTDDLEDDNFSLNDY---- 489
            |..|:..|..|.|....: :..|:..|:.|:.|     |...|           ...|:|.
Human   445 LACLNGDYEVEPGYGHER-NSFLKTHNIETFFIVPSHRRKIFP-----------GLILSDIKPAK 497

  Fly   490 RFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCK--IRRPMHRIAKEDINEEYRFHLESYY- 551
            |..|. :..|..:|:...|.|.  ...:|.:.|.||:  .:|...|.|.|.:.....|.....|
Human   498 RMKFK-TVCYLLVQLMHCRKMF--KAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYT 559

  Fly   552 ---------------------------LFT-TFRSWRMEWSFNKMRDLLMKYSLGMMVFAGATII 588
                                       .|| .::....|..:::::|   :|      |..|.::
Human   560 TPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQD---EY------FTSAVVL 615

  Fly   589 AMDLLVKSEAMDYTMLFSLFLLILLPL------LLASYKKLWLRGRRLSPITQPTFFLSRWFIKA 647
            .: :|.....:.|.::|...:::||.|      |:|..  |:|.      ||:...|.....|:
Human   616 TL-ILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACV--LYLH------ITRVQCFPGCLTIQ- 670

  Fly   648 SDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCDIARLELEIINSELHNLRPQMLCFMPWGVT-- 710
                     :|..|.|.::.|:|.::...|..|                        :||..:
Human   671 ---------IRTVLCIFIVVLIYSVAQGCVVGC------------------------LPWAWSSK 702

  Fly   711 -YAVVIVLS-------------------LMLVIIG-IPLIIKLGVG---LAILGSHVITVHAYYG 751
             .:.::|||                   |:..::| :||.|...|.   ..||.|.:.|   .|.
Human   703 PNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTT---SYI 764

  Fly   752 FAFERSQTTNIGVTSSLAHSW----YMVAFFIVVVVREGYLNYILKASY-FMSMCFEKKHELTKV 811
            ...|.|..|..|..:....|:    .::.|...:.:....::..|:..| :.:...|::.::.||
Human   765 LVLELSGYTRTGGGAVSGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKV 829

  Fly   812 KTRTIKIIMANILPTHVAEVFKVRR-RSDQLYYENFSQVAVMFATIENY-----EADKSG----- 865
            |....:|:. |:||.|||:.|.:.. |:..|||:::|||.||||:|.|:     |.|.:.
Human   830 KLDNRRILF-NLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVEC 893

  Fly   866 LRALHEMICYFDELLVNYQSWYK-IEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQ 929
            ||.|:|:|..||||:  .:.:|| |||||.:|.||:||.||
Human   894 LRLLNEIIADFDELM--EKDFYKDIEKIKTIGSTYMAAVGL------------------------ 932

  Fly   930 KSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRILRDI--RSKGIFFEKDSK 992
                   ||..|          |:|..:...: :..:.:||:.:..:|.:|  :|...|.
Human   933 -------APTSG----------TKAKKSISSH-LSTLADFAIEMFDVLDEINYQSYNDFV----- 974

  Fly   993 LTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDFNIRC 1057
                |::||..|||:|||:|..:|.|||||:|||:||||.||||:..|.|||....:||    ||
Human   975 ----LRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLR----RC 1031

  Fly  1058 TY----RGMTFVKGVGQVPTYLVD 1077
            .|    ||...|||.|::.||.::
Human  1032 PYHFVCRGKVSVKGKGEMLTYFLE 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	AcyC	51..445	CDD:441717	115/400 (29%)
		Nucleotidyl_cyc_III	283..439	CDD:448371	69/155 (45%)
		AcyC	681..1076	CDD:441717	129/443 (29%)
		Nucleotidyl_cyc_III	841..1076	CDD:448371	92/251 (37%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		AcyC	100..456	CDD:441717	114/397 (29%)
		Guanylate_cyc	294..476	CDD:425528	75/182 (41%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520		6/29 (21%)
		Guanylate_cyc	859..1056	CDD:425528	92/254 (36%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		10/26 (38%)