Protein Alignment CG32301 and adcy4

DIOPT Version :9

• Sequence 1: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Sequence 2: XP_002934331.3
• Gene: adcy4 / 100497212
• XenbaseID: XB-GENE-984909
• Length: 1072
• Species: Xenopus tropicalis
• Alignment Length: 1144
• Identity: 325/1144 - (28%)
• Similarity: 520/1144 - (45%)
• Gaps: 187/1144 - (16%)

  Fly    27 RYKC-RELRLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVK----NIDFLTVLPYFA 86
            |.:| :|..|...|:|......|.|:..||::.....||  |:.|:..:    |:.||..|  |.
 Frog    13 RQRCEKEGPLYETYYRLTQQYPVILLLLLIVLAVCCALI--IITFATGRTFSDNVGFLVTL--FC 73

  Fly    87 VMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDLILPICYFRPFS--LVPSYDHV---- 145
            .:.:...:.:|.....|.|        .|:..:.:..:..::.:.|...|:  ||.::|.:
 Frog    74 ALGVFSILFIPVCIKKVVQ--------KCMQIIGVVILGCLVTLGYVFIFTSGLVSAWDQIYWTL 130

  Fly   146 -VIVLIYLMFPIAFVKNGRAYFLGLAVSLFYFGYMALIDKISTL------DKVWELTAYGAYLFF 203
             ||:.:|.|.|:..   ..|.|.||  |.|....:.|...:||:      |...::.|....|..
 Frog   131 FVIISLYTMLPLGM---KWAIFAGL--SCFVAHIIVLSVYVSTVRLLPRDDVALQMIADAVILLC 190

  Fly   204 LNML-----CMFLSRFQE--YNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQD 261
            .|::     |:..|..::  :...:.|.||.::|.|.       ::::.||.||:|..:|..::.
 Frog   191 GNVIGGYHKCVTESALKDTYHEAINFIHSRLKLVSQE-------RQQERLLLSILPAYIATEMKA 248

  Fly   262 AIASHIEE---DPSNLMPFTKTRHLFMEPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELFVS 323
            .|...::|   .|.|...|   .:|:::.|.:||||.||:|.||.|::.....:||.:|:|||..
 Frog   249 EIIERLKEKRPQPENTNNF---HNLYIKRHKDVSILYADIVGFTLLSSECSPKELVLMLNELFGK 310

  Fly   324 FDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRIGV 388
            ||..|..|...|||.|||.|.||:|:|.:.|.||..||...|||.:..|::.|.....|::|:||
 Frog   311 FDQIAKDNECMRIKILGDCYYCVSGLPEFLPNHAKNCVLMGLDMCQAIRKLRKATGVDINMRVGV 375

  Fly   389 HSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLDNHYVYEEGTDTAKLD 453
            |||.:|.|:|||.|||:|:||.||.:.|.:|:.|:||.|||:..||..|:|.|..|:.| .|:.|
 Frog   376 HSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITEATLSHLENEYEVEDAT-LAQRD 439

  Fly   454 PLLQRSNLSTYL-IRSRLPNFEDTDDLEDDNFSLNDYRFSFSFSQDYEDIQVK------AQRDMI 511
            ..|:.:|:.||| |..|..:.|..|.|...:..:...|.|...::..|....:      :.||.:
 Frog   440 LYLKENNIKTYLVIDPRANDGEAEDILPSKSAEVPKMRASVRMTRYLESWGAEKPFAHLSHRDSL 504

  Fly   512 LEVEH-------MPVNRV-QTCKIRRPMH-RIAKEDINEEYRFHLESYYLFTTFRSWRMEWSFN- 566
            :...|       :|::.: ||....:... |...|.:|:. .||:..  :..:.|.|:....||
 Frog   505 VPEPHSISHSMDLPMSPLSQTWSQEKSRSTRETNESLNDN-NFHIME--VLASQRQWKRSKDFNR 566

  Fly   567 --------------KMRDL-LMKYSLGMMVFAGATIIAMDLLVKSE----AMDYTMLFSLFLLIL 612
                          ::.|| ..||......|..|....:.:||..:    .:.|.:.|..|||:|
 Frog   567 ITLYFNDKAAEKEYRLSDLPSFKYYTACCFFIFACNFIVQILVSHKNAAFGISYGISFFFFLLLL 631

  Fly   613 LPLLLASYKKLWLRGRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETV 677
            .........:..|:|.:          |..|....|..:....::|:||.:..:..:.||:...:
 Frog   632 FTCFAGHLARCILKGPQ----------LLHWLPSLSIALSSRPWLRVPLGVFTILTVLVMAVFNL 686

  Fly   678 FSCDIARLELEIINSELH-NLRPQMLCFMPWGVTYAVVIVLSLM-------------LVIIGIPL 728
            |.........:..||.|. :..||||..:|:   |....:|.|:             |:::.|.|
 Frog   687 FFLPDNNCPQQSWNSSLSPDPEPQMLYSLPY---YMYCCILGLLACSAFLLMNFEAKLILLSIAL 748

  Fly   729 IIKLGVGLAILGSHVITVHAYYGFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNYILK 793
            :|   ..:..|.:|......|..:.:.......|.....:..|..:..||..::.......|..:
 Frog   749 VI---YNVIFLETHSWLSDCYVNWLYMNHSRPGILKEPKVMGSISLFIFFFTLLALSRQNEYYCR 810

  Fly   794 ASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVF-KVRRRSDQLYYENFSQVAVMFATIE 857
            ..:.....|:.:.|..:......::::.|:||..||:.| ...||::.|||:::..|.|:||:|.
 Frog   811 LDFLWKRKFKMERERIETMENLNRVLLENVLPADVAQQFIGQNRRNEDLYYQSYDCVCVLFASIP 875

  Fly   858 NY-----EADKSG-----LRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTD 912
            ::     |.|::.     ||.|:|:|..||||| :...:..:||||.:|..|:||.||:.
 Frog   876 DFKEFYTECDENHEGLECLRLLNEIIADFDELL-SKPKFSSVEKIKTIGSAYMAATGLNA----- 934

  Fly   913 FSVSVPISTNRESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNEDDNTILVMTEFALNLLRIL 977
                   ::.:|:            |.|||               .:.|.|.:|.|||:.|:..|
 Frog   935 -------TSGQEN------------PQDGD---------------RNYNHIGIMVEFAIALIGKL 965

  Fly   978 RDIRSKGIF--FEKDSKLTGSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGI 1040
             |:.:|..|  |:        |::||.||||:|||:|..||.|||||:|||:||||.||||...|
 Frog   966 -DLINKHSFNNFK--------LRVGINHGPVVAGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKI 1021

  Fly  1041 HVTESTANVLRDFNIRCTYRGMTFVKGVGQVPTYLVDLD 1079
            .|||.|..||.....:|..||:..|||.||:.||.|..|
 Frog  1022 QVTEETTKVLEKLGYKCERRGVIKVKGKGQLCTYFVSTD 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	74/155 (48%)
		CYCc	812..1051	CDD:214485	90/251 (36%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	93/246 (38%)
adcy4	XP_002934331.3	AC_N	<17..250	CDD:318454	57/256 (22%)
		Guanylate_cyc	270..427	CDD:306677	74/156 (47%)
		DUF1053	483..586	CDD:399378	17/105 (16%)
		Guanylate_cyc	859..1057	CDD:306677	93/246 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48748
Panther	1	1.100	-	-	O	PTHR45627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110