Protein Alignment ACXD and Adcy7

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_445848.1
• Gene: Adcy7 / 84420
• RGDID: 619966
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 1201
• Identity: 325/1201 - (27%)
• Similarity: 529/1201 - (44%)
• Gaps: 238/1201 - (19%)

  Fly    53 YDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSGLVIWVVLGVNFRSE 117
            |:.|....:.|.|.|.:.:....|.|..:.::.:.|....:..::......|.::|.|.|....|
  Rat    22 YEKYRLTSQHGPLLLLLLLVAVATCIALVSIVFSHEDLRRHQAVLGTAFFMLTLFVALYVLVYVE 86

  Fly   118 LVSKHGW--VVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMP-VPYLLQ 179
            .:::. |  |:...:|  .|:|:|..:       ...:.:.|..| |:.....::|:. |.|:|.
  Rat    87 CLAQR-WLRVLALLTW--ACLMILGSV-------LMWDSLENEAY-AWEQVPFFLFIVFVVYVLL 140

  Fly   180 P------FVLGSAVTFCYIINYSFVI----TAKDDNQMH-SILNEAIYLSCVNLLGIFFRLMRDI 233
            |      ..:|.|.|..:::.:..|.    |:....|:. .:|..|:.|...|..|.|.:.....
  Rat   141 PLSTRAAIAVGVASTISHLLVFGAVTRAFKTSMSSTQLGLQLLANAVILLGGNFTGAFHKHQLQD 205

  Fly   234 ALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDL 298
            |.|..|:...:.::....||..:.|:.:||||:|||.|:..::..:..|::....:|.
  Rat   206 ASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHY------- 263

  Fly   299 RRSADSQTLKRWRQPDHG--TLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDI 361
                         .||:.  :|:::.|::|::||||:|.:|.|.:....|:||..|::||.:||.
  Rat   264 -------------TPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQ 315

  Fly   362 ASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSG 426
            .::....:|||.||||||||:||......||:.||.:||.:.:.|:.|||...::|.||:|:|||
  Rat   316 IAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSG 380

  Fly   427 DVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVL 491
            :||.||||..|||:|:||.||.:|||:||.|..||||:::.||:.||..|..|||..:.| ||.|
  Rat   381 NVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQR-DPYL 444

  Fly   492 QKHGIRTFLIKSLRA-----PMHDPRRRMRERQVKKLSEASKANFMHNSTLHQYNQVRNQAKLEM 551
            ::..|||:|:...|:     |.|...:...:..:|     .:|:......|..:...|..|.|..
  Rat   445 KEMNIRTYLVIDPRSQQPPLPSHHLSKPKGDATLK-----MRASVRVTRYLESWGAARPFAHLNH 504

  Fly   552 CRELDK----MPIGRIQLTKVFRR----------STRLTQDEIEEETFR--RNISS---CCL--- 594
            ...:..    :|.||.|.....||          ..|| :|:.::|...  ..:||   ||.
  Rat   505 RESVSSSEIPIPNGRRQKAIPLRRHRAPDRSASPKGRL-EDDCDDEMLSAIEGLSSTRPCCSKSD 568

  Fly   595 -------FFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLLSKDARYHYWYIDGTTIILL 652
                   .|..:.:|.:|...|....:|..|.|.::::.:|.:.||............|....||
  Rat   569 DFHTFGPIFLEKGFEREYRLVPIPRARYDFACASLVFVCILLVHLLVMPRMATLGLSFGLVACLL 633

  Fly   653 TMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQ 717
            .::|.        ..:.::.....|   ....|..:|:.::...::|:.:..:.:.|...|||:.
  Rat   634 GLVLS--------FCFATEFSRCLP---ARSTLQAISESVETQPLLRLSLVVVTVGSLLTVAIIN 687

  Fly   718 V-------VGCSSDEDYADLDPTYDERVQC-FHPWILTNCMTLVIGMSFLFTRIPFIIKSCFSAL 774
            :       .....|.:.:.|.........| ..|:...:|:...|..| :|.|:...:|:....:
  Rat   688 MPLTFNPGPEQPGDNETSPLAARNRVGTPCELLPYYTCSCVLGFIACS-VFLRMSLELKAMLLTV 751

  Fly   775 IMIGYAVLVVSEFNF-----IYANSPSTNVNFNAK---------YSHIL---------------- 809
            .::.|.:|    ||.     :..||..||.....:         .||.|
  Rat   752 ALVAYLLL----FNLSPCWQVSGNSTETNSTHRTRRLLSAEQSMNSHTLALGAQMTAPSPSSCLE 812

  Fly   810 ---------LMIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHV 865
                     .:::.:....|:.||.::..::|..||::..|:.|:.....:..::||.|:||.||
  Rat   813 RDLKTMINFYLVLFYATLILLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHV 877

  Fly   866 ADFYLSNQLQNELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKY 920
            |..::.::...:.|::.||.|.|||||:.:|       |.:|.|   ||:|||||.|||::|.|.
  Rat   878 AAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKP 942

  Fly   921 SQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRV 985
            ..| .|||||....|||||.||.|                   |:|..::
  Rat   943 KFS-GVEKIKTIGSTYMAAAGLSV-------------------PSGHENQ--------------- 972

  Fly   986 PYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENM 1050
                        ||||              ...|.|        |:.||::.||..:...|..:.
  Rat   973 ------------DLER--------------KHVHIG--------VLVEFSMALMSKLDGINRHSF 1003

  Fly  1051 QTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALK 1115
            .:        ..||:||:||..:|||:|..||.||||||.||:||||:|||..|:|||||.|...
  Rat  1004 NS--------FRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTI 1060

  Fly  1116 LREFNIQCNYRGMTFVKGRGNIPTYIIGIDS 1146
            |:.....|..||:..|||:|.:.||.:..|:
  Rat  1061 LQGLGYSCECRGLINVKGKGELRTYFVCTDT 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	54/244 (22%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	87/181 (48%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	97/273 (36%)
Adcy7	NP_445848.1	AcyC	48..461	CDD:441717	139/444 (31%)
		Guanylate_cyc	272..422	CDD:425528	72/149 (48%)
		Adcy_cons_dom	487..594	CDD:461877	22/107 (21%)
		Guanylate_cyc	891..1087	CDD:425528	97/272 (36%)